cholest-5-en-3-carboxylic acid | 32450-33-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: cholest-5-en-3-carboxylic acid
• 英文别名: cholesteryl formate；cholest-5-ene-3β-carboxylic acid；Cholest-5-en-3β-carbonsaeure；Cholesten-(5)-carbonsaeure-(3β)；Δ⁵-Cholesten-3β-carbonsaeure；Cholest-5-ene-3 b-carboxylic acid；(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid
• CAS: 32450-33-2
• 化学式: C₂₈H₄₆O₂
• 分子量: 414.672
• InChiKey: CGHGJNRXRSZLJH-LBGFUSKISA-N

物化性质

• 熔点：
  230-231 °C
• 沸点：
  520.9±19.0 °C(Predicted)
• 密度：
  1.02±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.9
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  cholest-5-en-3-carboxylic acid 在 lithium aluminium tetrahydride 作用下， 生成 3-hydroxymethylcholest-5-ene
  参考文献：
  名称：

  Derived Steroids. IV. 3-α-Cholesterylacetic Acid¹

  摘要：

  DOI：

  10.1021/ja01153a007
• 作为产物：
  描述：

  cholesterol 在 乙醚 、 magnesium 、 三氯氧磷 作用下， 生成 cholest-5-en-3-carboxylic acid
  参考文献：
  名称：

  衍生类固醇；胆固醇酮。

  摘要：

  DOI：

  10.1021/ja01184a056

文献信息

• SOLUBLE STEROIDAL PEPTIDES FOR NUCLEIC ACID DELIVERY
  申请人：Mahato I. Ram

  公开号：US20050032722A1

  公开（公告）日：2005-02-10

  Amphiphilic lipopeptide compositions for gene delivery are disclosed. An illustrative amphiphilic lipopeptide composition includes a human protamine 2 peptide conjugated to a hydrophobic moiety. Illustrative hydrophobic moieties include sterols, bile acids, and fatty acids. The amphiphilic lipopeptide composition is mixed with a nucleic acid such that the nucleic acid binds to the peptide portion of the lipopeptide. This mixture is placed in contact with mammalian cells to effect transfection of the cells with the nucleic acid. A method of making such amphiphilic lipopeptides is also described.

  揭示了用于基因传递的两性脂肽组合物。一个示例的两性脂肽组合物包括将人类前白蛋白2肽与一个疏水基团结合。示例的疏水基团包括类固醇、胆汁酸和脂肪酸。将两性脂肽组合物与核酸混合，使核酸结合到脂肽的肽段上。将这种混合物与哺乳动物细胞接触，以实现细胞对核酸的转染。还描述了制备这种两性脂肽的方法。
• RADIATION SENSITIVE LIPOSOMES
  申请人：Bondurant Bruce

  公开号：US20090304589A1

  公开（公告）日：2009-12-10

  The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposome composition comprising a stable liposome-forming lipid and a polymerizable colipid, and a chain transfer agent. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.

  本发明涉及一种辐射敏感的脂质体，以及将该脂质体用作治疗和诊断药物的载体。特别地，本发明涵盖了一种脂质体组合物，包括稳定的脂质体形成脂质和可聚合的共脂质以及链转移剂。本发明还涵盖了利用脂质体封装或关联的药物诊断和治疗对脂质体敏感的疾病和病症的方法。
• Cationic amphiphiles of cholesterol
  申请人：University of Tennessee Research Company

  公开号：US20030012813A1

  公开（公告）日：2003-01-16

  A stable aqueous dispersion which comprises a cationic lipid which is a molecule which comprises a cholesterol-derived lipophilic group, a linker bond which is hydrolyzable by cellular enzymes and relatively resistant to base-catalyzed hydrolysis, a spacer arm and a cationic amino group, and an appropriate co-lipid. The invention also includes the cationic lipids and mammalian plasmid DNA or other cells in admixture with the aqueous dispersion.

  一种稳定的水相分散体，包括一种阳离子脂质，该脂质是一种分子，包括一个由胆固醇衍生的亲脂性基团，一个可被细胞酶水解的连接键，相对抗碱催化水解，一个间隔臂和一个阳离子氨基团，以及适当的共脂质。该发明还包括阳离子脂质和哺乳动物质粒DNA或其他细胞与水相分散体混合的组合物。
• Soluble steroidal peptides for nucleic acid delivery
  申请人：Mahato I. Ram

  公开号：US20050287671A1

  公开（公告）日：2005-12-29

  Amphiphilic lipopeptide compositions for gene delivery are disclosed. An illustrative amphiphilic lipopeptide composition includes a human protamine 2 peptide conjugated to a hydrophobic moiety. Illustrative hydrophobic moieties include sterols, bile acids, and fatty acids. The amphiphilic lipopeptide composition is mixed with a nucleic acid such that the nucleic acid binds to the peptide portion of the lipopeptide. This mixture is placed in contact with mammalian cells to effect transfection of the cells with the nucleic acid. A method of making such amphiphilic lipopeptides is also described.

  本发明公开了用于基因递送的两亲脂肽组合物。一种说明性的两亲脂肽组合物包括与疏水分子共轭的人原胺 2 肽。说明性疏水分子包括固醇、胆汁酸和脂肪酸。两亲性脂肽组合物与核酸混合，使核酸与脂肽的肽部分结合。将这种混合物与哺乳动物细胞接触，使细胞转染核酸。此外，还介绍了制造这种两亲性脂肽的方法。
• Roberts et al., Journal of the Chemical Society, 1954, p. 2705,2712
  作者：Roberts et al.

  DOI：——

  日期：——