3β-6-methyl-cholest-5-en-3-ol | 43217-66-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β-6-methyl-cholest-5-en-3-ol
• 英文别名: 6-methylcholest-5-en-3β-ol；6-methylcholesterol；6-methyl-cholesten-(5)-ol-(3β)；(10R)-3c-Hydroxy-6.10r.13c-dimethyl-17c-((R)-1.5-dimethyl-hexyl)-(8cH.9tH.14tH)-Δ⁵-tetradecahydro-1H-cyclopenta[a]phenanthren；3β-Hydroxy-6.10.13-trimethyl-17β-((R)-1.5-dimethyl-hexyl)-gonen-(5)；Cholest-5-en-3-ol, 6-methyl-, (3beta)-；(3S,8S,9S,10R,13R,14S,17R)-6,10,13-trimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 43217-66-9
• 化学式: C₂₈H₄₈O
• 分子量: 400.689
• InChiKey: SDFPRGWZYZGEBH-ROUDTPAMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3β-6-methyl-cholest-5-en-3-ol 在 吡啶 、 氢碘酸 、 sodium acetate 作用下， 以 丙酮 为溶剂， 生成 3-Jod-6-methyl-cholesten-(5)
  参考文献：
  名称：

  Davis,M. et al., Bulletin de la Societe Chimique de France, 1960, p. 742 - 746

  摘要：

  DOI：
• 作为产物：
  描述：

  cholesterol 在 过氧化氢苯甲酰 、 乙醚 、 氯仿 作用下， 生成 3β-6-methyl-cholest-5-en-3-ol
  参考文献：
  名称：

  Interlocking Directorates: An Example of Tacit Knowledge Transfer

  摘要：

  This paper illustrates tacit knowledge flows between American and Canadian metropolitan areas. Using the spatial distribution of interlocking in Canada and the United States a spatial component is added to the resource dependency paradigm. Using a poisson regression model. components of cities that initiate and attract interlocking, and thus knowledge transfer, can be identified. From the results, the authors propose the concept of a "knowledge threshold" essential for the transfer of tacit knowledge. In Canada the "knowledge threshold" encompasses the entire country while it is more regionally based in the United States.

  DOI：

  10.2747/0272-3638.23.2.154

文献信息

• SYNTHESIS OF 6-METHYLCHOLESTA-3.5-DIENE; SOLVOLYSIS OF 6-METHYLCHOLESTERYL IODIDE
  作者：George Just、Edward Lee-Ruff

  DOI：10.1139/v66-389

  日期：1966.11.1

  not available

  不可用。
• Photorearrangements of Some Methyl-substituted Cholest-5-en-3β-ol Nitrites
  作者：Hiroshi Suginome、Norio Maeda、Makoto Kaji、Kyohei Takakuwa

  DOI：10.1246/bcsj.56.3349

  日期：1983.11

  Photolysis of 6-methylcholest-5-en-3β-ol nitrite and 4,4,6-trimethylcholest-5-en-3β-ol nitrite in benzene with monochromatic light respectively gave a seven-membered cyclic hydroxamic acid arising from rearrangement albeit in low yields. Photolysis of 3α-methylcholest-5-en-3β-ol nitrite and 3α,4,4-trimethylcholest-5-en-3β-ol nitrite respectively gave a nitroso dimer arising from β-scission.

  6-methylcholest-5-en-3β-ol 亚硝酸盐和 4,4,6-trimethylcholest-5-en-3β-ol 亚硝酸盐在苯中用单色光分别光解得到重排产生的七元环异羟肟酸，尽管在产量低。3α-methylcholest-5-en-3β-ol 亚硝酸盐和 3α,4,4-trimethylcholest-5-en-3β-ol 亚硝酸盐的光解分别产生由 β 断裂产生的亚硝基二聚体。
• Photo- and Thermally-induced Radical Rearrangements of 6-Methyl- and 4,4,6-Trimethylcholest-5-en-3β-ol
  作者：Hiroshi Suginome、Norio Maeda、Yoshikatsu Seki、Kazuhiko Orito

  DOI：10.1246/bcsj.55.1653

  日期：1982.5

  The irradiation of 6-methylcholest-5-en-3β-ol in benzene containing mercury(II) oxide and iodine gave 3α,5-epoxy-6-methylene-A-homo-4-oxa-5α-cholestane (23%) and 2-iodo-6-methyl-A-nor-2,3-secocholest-5-en-3-yl formate (32%). The thermally-induced reaction at 55–60 °C gave the former in a 16% yield. The corresponding photo-reaction of 4,4,6-trimethylcholest-5-en-3β-ol, however, gave 4,6-dimethyl-4-methylene-3,4-secocholest-5-en-3-al.

  在含有氧化汞（II）和碘的苯中辐照 6-甲基胆甾烯-5-烯-3β-醇，可得到 3α,5-环氧-6-亚甲基-A-高-4-氧杂-5α-胆甾烯（23%）和 2-碘-6-甲基-A-去甲-2,3-苯并胆甾烯-5-烯-3-甲酸酯（32%）。在 55-60 °C的热诱导反应中，前者的产率为 16%。而 4,4,6-三甲基-5-胆甾烯-3β-醇的相应光反应则生成了 4,6-二甲基-4-亚甲基-3,4-secocholest-5-烯-3-al。
• Mikaya, A. I.; Antonova, A. V.; Zaikin, V. G., Doklady Chemistry, 1984, vol. 279, p. 402 - 404
  作者：Mikaya, A. I.、Antonova, A. V.、Zaikin, V. G.、Prostakov, N. S.、Vul'fson, N. S.、Torgov, I. V.

  DOI：——

  日期：——