N-γ-glutamyl-S-(1-propenyl)cysteine | 91216-96-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-γ-glutamyl-S-(1-propenyl)cysteine
• 英文别名: γ-glutamyl-S-1-propenylcysteine；gamma-glutamyl-S-trans-propenyl cysteine；γ-L-Glutamyl-S--L-cystein；gamma-l-glutamyl-S-(prop-1-enyl)cystein；(2S)-2-amino-5-[[(1R)-1-carboxy-2-prop-1-enylsulfanylethyl]amino]-5-oxopentanoic acid
• CAS: 91216-96-5
• 化学式: C₁₁H₁₈N₂O₅S
• 分子量: 290.34
• InChiKey: MUFSTXJBHAEIBT-YUMQZZPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  155
• 氢给体数：
  4
• 氢受体数：
  7

制备方法与用途

γ-谷氨酰-S-1-丙烯基半胱氨酸是从大蒜中提取的一种化合物。

反应信息

• 作为反应物：
  描述：

  N-γ-glutamyl-S-(1-propenyl)cysteine 生成 S-(1-propenyl)-L-cysteine
  参考文献：
  名称：

  Mattikala,E.J.; Virtanen,A.I., Acta Chemica Scandinavica (1947), 1962, vol. 16, p. 2461 - 2462

  摘要：

  DOI：

文献信息

• AUTOPHAGY ACTIVATING AGENT
  申请人：Wakunaga Pharmaceutical Co., Ltd.

  公开号：EP3804709A1

  公开（公告）日：2021-04-14

  To provide a compound used for activating autophagy, which has few side effects and mild effects. An autophagy activating agent comprising S1PC or a salt thereof as an active ingredient.

  提供一种用于激活自噬的化合物，其副作用小且效果温和。 一种自噬激活剂，其活性成分包括 S1PC 或其盐。
• Changes of <i>S</i>-Allylmercaptocysteine and γ-Glutamyl-<i>S</i>-allylmercaptocysteine Contents and Their Putative Production Mechanisms in Garlic Extract during the Aging Process
  作者：Takuto Fujii、Toshiaki Matsutomo、Yukihiro Kodera

  DOI：10.1021/acs.jafc.8b02541

  日期：2018.10.10

  gamma-Glutamyl-S-allylmercaptocysteine (GSAMC), a putative precursor compound of S-allylmercaptocysteine (SAMC), was isolated and identified from aged garlic extract (AGE). We analyzed the change of their contents in AGE during the aging process, chronologically from 1 to 22 months. The formation of these compounds occurred mostly during the early stage of the aging period: the SAMC content reached a maximum at approximately 4 months, whereas the GSAMC content reached a maximum at 1 month and then decreased during the subsequent aging period. To assess the possible relationship between the change of the two compounds during the aging process, we set up the model reactions with the hypothesis that GSAMC is produced from gamma-glutamyl-S-allylcysteine (GSAC)/gamma-gultamyl-S-1-propenylcysteine (GS1PC) and that SAMC is produced from GSAMC by endogenous gamma-glutamyl transpeptidase (GGT) in garlic during the early stage of the aging process. We found that, in the model reactions, SAMC was produced from GSAMC by the garlic protein fraction having GGT activity and its production was suppressed by a GGT inhibitor. Furthermore, the production of GSAMC from allicin and GSAC/GS1PC was found in another model reaction. The reaction between allicin and GS1PC was faster than that between allicin and GSAC and, thus, may be involved in the production of GSAMC in the early stage of the aging process.
• ABSORPTION PROMOTER FOR GARLIC COMPONENTS
  申请人：KENKOUKAZOKU CO., LTD.

  公开号：US20190282652A1

  公开（公告）日：2019-09-19

  The present invention relates to an absorption promoter for S-allyl cysteine (SAC) and alliin containing Garlic-Egg yolk.
• Mattikala,E.J.; Virtanen,A.I., Acta Chemica Scandinavica (1947), 1962, vol. 16, p. 2461 - 2462
  作者：Mattikala,E.J.、Virtanen,A.I.

  DOI：——

  日期：——