2-[[[(carboxymethyl)oxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium | 853798-56-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[[[(carboxymethyl)oxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium
• 英文别名: carboxymethyl phosphorylcholine；Carboxymethyl (2-(trimethylammonio)ethyl) phosphate；carboxymethyl 2-(trimethylazaniumyl)ethyl phosphate
• CAS: 853798-56-8
• 化学式: C₇H₁₆NO₆P
• 分子量: 241.181
• InChiKey: SRZQXACEDDIGEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  95.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[[[(carboxymethyl)oxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium 在 二乙胺 、 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.5h， 生成
  参考文献：
  名称：

  [EN] MODIFIED AMINO ACIDS AND APPLICATION THEREOF IN ADC
  [FR] ACIDES AMINÉS MODIFIÉS ET LEUR UTILISATION DANS UN ADC
  [ZH] 修饰的氨基酸及其在ADC中的应用

  摘要：

  提供修饰的氨基酸及其在ADC中的应用，所述修饰的氨基酸为R1-L1-N(R2)-R3所示的磷酰胆碱基团修饰的氨基酸，其中，R1、L1、N、R2和R3如文中所定义。还提供含有所述修饰的氨基酸的肽。用这类修饰的氨基酸或修饰的肽制得的ADC具有明显提高的溶解度。

  公开号：

  WO2022199237A1
• 作为产物：
  描述：

  甘磷酸胆碱 在 ruthenium trichloride 、 sodium periodate 作用下， 以 水 、 乙腈 为溶剂， 以19 g的产率得到2-[[[(carboxymethyl)oxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium
  参考文献：
  名称：

  [EN] MODIFIED AMINO ACIDS AND APPLICATION THEREOF IN ADC
  [FR] ACIDES AMINÉS MODIFIÉS ET LEUR UTILISATION DANS UN ADC
  [ZH] 修饰的氨基酸及其在ADC中的应用

  摘要：

  提供修饰的氨基酸及其在ADC中的应用，所述修饰的氨基酸为R1-L1-N(R2)-R3所示的磷酰胆碱基团修饰的氨基酸，其中，R1、L1、N、R2和R3如文中所定义。还提供含有所述修饰的氨基酸的肽。用这类修饰的氨基酸或修饰的肽制得的ADC具有明显提高的溶解度。

  公开号：

  WO2022199237A1

文献信息

• Method For Producing Protein Adsorption-Preventing Ocular Lens Material
  申请人：Suda Yukimitsu

  公开号：US20080038221A1

  公开（公告）日：2008-02-14

  The present invention is a method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded onto the surface of an eye lens material wherein a chemical compound having an end amino group is introduced to said eye lens material and then the chemical compound represented by the following formula (2) or (3) is introduced through said chemical compound having an end amino group. The object of the present invention is to provide a method of manufacturing a contact lens that prevents protein adsorption. n denotes a natural number 1-18.

  本发明是一种制造眼镜镜片材料的方法，其中包括以下公式（1）所代表的含有磷酰胆碱基团的化合物与眼镜镜片材料表面发生反应并共价结合的过程，其中引入具有末端氨基团的化合物至所述眼镜镜片材料，然后通过具有末端氨基团的化合物引入以下公式（2）或（3）所代表的化合物。 本发明的目的是提供一种制造隐形眼镜的方法，以防止蛋白质吸附。 n表示自然数1-18。
• Affinity Particle And Method Of Affinity Separation
  申请人：Miyazawa Kazuyuki

  公开号：US20090321358A1

  公开（公告）日：2009-12-31

  The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of organic particles and also by having ligands having specific affinity with a certain target substance covalently bonded or adsorbed onto the surface of organic particles. The object of the present invention is to provide an affinity separation method that uses affinity particles utilizing organic particles and is capable of separating the target substance easily and with high accuracy.

  本发明涉及一种亲和性颗粒，其特征在于磷酸胆碱基团以以下公式（1）共价键结合于有机颗粒的表面，并且具有特定亲和力的配体共价键结合或吸附于有机颗粒的表面。本发明的目的是提供一种利用有机颗粒制备的亲和性颗粒的亲和分离方法，能够轻松且高精度地分离目标物质。
• AFFINITY PARTICLE AND METHOD OF AFFINITY SEPARATION
  申请人：Shiseido Company, Limited

  公开号：EP1750127A1

  公开（公告）日：2007-02-07

  The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of organic particles and also by having ligands having specific affinity with a certain target substance covalently bonded or adsorbed onto the surface of organic particles. The object of the present invention is to provide an affinity separation method that uses affinity particles utilizing organic particles and is capable of separating the target substance easily and with high accuracy.

  本发明是亲和颗粒，其特征在于有机颗粒表面共价键合有下式(1)代表的磷酸胆碱基团，有机颗粒表面还共价键合或吸附有与某种目标物质具有特定亲和力的配体。 本发明的目的是提供一种亲和分离方法，该方法使用利用有机颗粒的亲和颗粒，能够轻松、高精度地分离目标物质。
• OCULAR LENS MATERIAL AND METHOD FOR PRODUCING SAME
  申请人：Shiseido Company, Limited

  公开号：EP1750158A1

  公开（公告）日：2007-02-07

  The present invention is an eye lens material wherein phosphorylcholine groups of a specific structure are covalently bonded onto the material surface by means of an after-treatment in which a phosphorylcholine-containing chemical compound is reacted with an eye lens material. The object of the present invention is to provide a contact lens that prevents protein adsorption and a method of manufacturing thereof.

  本发明是一种眼透镜材料，通过含磷酸胆碱的化合物与眼透镜材料反应的后处理，将特定结构的磷酸胆碱基团共价键合到材料表面。 本发明的目的是提供一种防止蛋白质吸附的隐形眼镜及其制造方法。
• METHOD FOR PRODUCING PROTEIN ADSORPTION-PREVENTING OCULAR LENS MATERIAL
  申请人：Shiseido Company, Limited

  公开号：EP1750160A1

  公开（公告）日：2007-02-07

  The present invention is a method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded onto the surface of an eye lens material wherein a chemical compound having an end amino group is introduced to said eye lens material and then the chemical compound represented by the following formula (2) or (3) is introduced through said chemical compound having an end amino group. The object of the present invention is to provide a method of manufacturing a contact lens that prevents protein adsorption.

  本发明是一种制造眼球镜片材料的方法，其工艺流程为：将下式（1）表示的含磷酸胆碱基团的化合物反应并共价键合到眼球镜片材料的表面，其中将具有末端氨基的化合物引入所述眼球镜片材料，然后通过所述具有末端氨基的化合物引入下式（2）或（3）表示的化合物。 本发明的目的是提供一种防止蛋白质吸附的隐形眼镜制造方法。