2,3-dimethoxyphenyl acetate | 27257-08-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 2,3-dimethoxyphenyl acetate
• 英文别名: 1-acetoxy-2,3-dimethoxy-benzene；1.2-Di-O-methyl-3-O-acetyl-pyrogallol；Essigsaeure-(2.3-dimethoxy-phenylester)；1-Acetoxy-2,3-dimethoxy-benzol；(2.3-Dimethoxy-phenyl)-acetat；2,3-Dimethoxyphenylacetat；(2,3-dimethoxyphenyl) acetate
• CAS: 27257-08-5
• 化学式: C₁₀H₁₂O₄
• 分子量: 196.203
• InChiKey: RVVWZHFHRWHWHT-UHFFFAOYSA-N

物化性质

• 沸点：
  246.2±25.0 °C(Predicted)
• 密度：
  1.120±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2915390090

反应信息

• 作为反应物：
  描述：

  2,3-dimethoxyphenyl acetate 在 三氯化铝 、 硝基苯 作用下， 生成 2'-羟基-3',4'-二甲氧基苯乙酮
  参考文献：
  名称：

  Mauthner, Journal fur praktische Chemie (Leipzig 1954), 1933, vol. <2> 136, p. 205,209

  摘要：

  DOI：
• 作为产物：
  描述：

  邻苯二甲醚 、 四乙基醋酸铵 在 zinc(II) chloride 作用下， 以 乙腈 为溶剂， 以12%的产率得到2,3-dimethoxyphenyl acetate
  参考文献：
  名称：

  Electrophilic components in the electrochemical acetoxylation of substituted arenes

  摘要：

  The mechanism of anodic acetoxylation of substituted arenes under conditions of undivided galvanostatic electrolysis in MeCN containing acetate is suggested and an important role of electrophilic components (AcOH or ZnCl2) catalyzing transformation of intermediate ipso-acetoxylated polysubstituted arenonium cations to corresponding ortho-acetoxylated arenonium cations, which give acetoxylation products after deprotonation, is experimentally proved.

  DOI：

  10.1016/j.mencom.2008.07.008

文献信息

• Steric Control of Site Selectivity in the Pd-Catalyzed C–H Acetoxylation of Simple Arenes
  作者：Amanda K. Cook、Marion H. Emmert、Melanie S. Sanford

  DOI：10.1021/ol4024248

  日期：2013.11

  and a ligand to control site selectivity in the Pd(OAc)2-catalyzed C–H acetoxylation of simple arenes. The use of MesI(OAc)2 as the terminal oxidant in combination with acridine as the ligand results in primarily sterically controlled selectivity. In contrast, with Pd(OAc)2 as the catalyst and PhI(OAc)2 as the oxidant, electronic effects dominate the selectivity of arene C–H acetoxylation.

  该报告描述了在简单的芳烃的Pd（OAc）2催化的C–H乙酰氧基化中使用氧化剂和配体来控制位点选择性。MesI（OAc）2作为末端氧化剂与a啶作为配体的组合使用，可实现主要的空间控制选择性。相比之下，以Pd（OAc）2为催化剂，PhI（OAc）2为氧化剂，电子效应决定了芳烃CH乙酰氧基化反应的选择性。
• PYRAZOLE INHIBITORS OF WNT SIGNALING
  申请人：Brunton Shirley Ann

  公开号：US20100137394A1

  公开（公告）日：2010-06-03

  The invention provides inhibitors of Wnt signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein R1 to R7 and Z are as defined herein.

  该发明提供了Wnt信号通路的抑制剂，其可用作治疗恶性肿瘤的治疗剂，其中化合物具有一般式I：其中R1至R7和Z的定义如本文所述。
• Golf ball
  申请人：Dunlop Sports Co., Ltd.

  公开号：EP2537887A2

  公开（公告）日：2012-12-26

  An object of the present invention is to provide a golf ball showing a great flight distance on driver shots. The present invention provides a golf ball comprising a spherical core and at least one cover layer covering the spherical core, wherein the spherical core is formed from a rubber composition containing (a) base rubber, (b) an α,β-unsaturated carboxylic acid having 3 to 8 carbon atoms and/or a metal salt thereof as a co-crosslinking agent, (c) a crosslinking initiator and (d) a carboxylic acid having 1 to 14 carbon atoms, provided that the rubber composition further contains (e) a metal compound in case of containing only (b) the α,β-unsaturated carboxylic acid having 3 to 8 carbon atoms as the co-crosslinking agent.

  本发明的目的是提供一种在发球木杆击球时飞行距离远的高尔夫球。本发明提供了一种高尔夫球，包括一个球形芯和至少一个覆盖在球形芯上的覆盖层，其中球形芯由橡胶组合物形成，该橡胶组合物含有(a)基础橡胶，(b)具有 3 至 8 个碳原子的α，β-不饱和羧酸和/或作为共交联剂的金属盐，(c)交联引发剂和(d)具有 1 至 14 个碳原子的羧酸、(c) 交联引发剂和 (d) 具有 1 至 14 个碳原子的羧酸，条件是在仅含有 (b) 具有 3 至 8 个碳原子的 α，β-不饱和羧酸作为共交联剂的情况下，橡胶组合物还含有 (e) 金属化合物。
• GOLF BALL
  申请人：Dunlop Sports Co., Ltd.

  公开号：EP2610291B1

  公开（公告）日：2017-12-20
• MODULATION OF NKT CELL ACTIVITY WITH ANTIGEN-LOADED CD1d MOLECULES
  申请人：VACCINEX, INC.

  公开号：US20170312356A1

  公开（公告）日：2017-11-02

  The invention is directed to methods of modulating an immune response in an animal, comprising administering a composition comprising one or more soluble CD1d complexes, in particular non-specific soluble CD1d complexes. Soluble CD1d complexes comprise a soluble CD1d polypeptide, a β2-microglobulin polypeptide, and a ceramide-like glycolipid antigen bound to the CD1d antigen binding groove, and in certain embodiments, an immunogen. The administration of compositions of the present invention affects the activity of CD1d-restricted NKT cells, and in particular, allows for multiple administrations without causing CD1d-restricted NKT cell anergy.