3-ethyl-2-(4-ethylphenyl)-3-hydroxyisoindolin-1-one | 1532556-63-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 3-ethyl-2-(4-ethylphenyl)-3-hydroxyisoindolin-1-one
• 英文别名: 3-Ethyl-2-(4-ethylphenyl)-3-hydroxyisoindol-1-one；3-ethyl-2-(4-ethylphenyl)-3-hydroxyisoindol-1-one
• CAS: 1532556-63-0
• 化学式: C₁₈H₁₉NO₂
• 分子量: 281.354
• InChiKey: GFYAPGVPFCBHSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(4-ethylphenyl)isoindoline-1,3-dione 、 diethylzinc 在 bis(1,5-cyclooctadiene)nickel (0) 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 以93%的产率得到3-ethyl-2-(4-ethylphenyl)-3-hydroxyisoindolin-1-one
  参考文献：
  名称：

  Nickel-Catalyzed Direct Addition of Diorganozinc Reagents to Phthalimides: Selective Formation of Gamma-Hydroxylactams

  摘要：

  The nickel-catalyzed addition of diorganozinc reagents to phthalimides proceeds with excellent selectivity to provide 3-substituted-3-hydroxyisoindolin-1-one products. These 3-hydroxy--lactams are produced cleanly in high yield with numerous examples of imide substitution and a broad range of diorganozinc reagents that are prepared and utilized without purification.

  DOI：

  10.1055/s-0033-1339890

文献信息

• Nickel-Catalyzed Direct Addition of Diorganozinc Reagents to Phthalimides: Selective Formation of Gamma-Hydroxylactams
  作者：Jeffrey Johnson、Joseph Dennis、Catherine Calyore、Jessica Sjoholm、J. Lutz、Joseph Gair

  DOI：10.1055/s-0033-1339890

  日期：——

  The nickel-catalyzed addition of diorganozinc reagents to phthalimides proceeds with excellent selectivity to provide 3-substituted-3-hydroxyisoindolin-1-one products. These 3-hydroxy--lactams are produced cleanly in high yield with numerous examples of imide substitution and a broad range of diorganozinc reagents that are prepared and utilized without purification.