6-acetoxy-4,5α-epoxy-3-methoxy-17-methyl-morphin-6-ene; hydrochloride | 20236-82-2

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: 6-acetoxy-4,5α-epoxy-3-methoxy-17-methyl-morphin-6-ene; hydrochloride
• 英文别名: 6-Acetoxy-4,5α-epoxy-3-methoxy-17-methyl-morphin-6-en; Hydrochlorid；(5α)-6,7-didehydro-4,5-epoxy-3-methoxy-17-methyl-morphinan-6-ol, acetate (ester), hydrochloride；(5α)-6,7-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-yl acetate hydrochloride；Thebacon hydrochloride；[(4R,4aR,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl] acetate;hydrochloride
• CAS: 20236-82-2
• 化学式: C₂₀H₂₃NO₄*ClH
• 分子量: 377.868
• InChiKey: OTQDEDKVELDPIY-ZKVYEUBZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.84
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  48
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Preparation of submicron sized particles with polymorph control
  申请人：——

  公开号：US20030096013A1

  公开（公告）日：2003-05-22

  The present invention provides a method of preparing particles with polymorph and size control of a pharmaceutical compound, the method including the steps of: (1) providing a pharmaceutical compound in a first phase; (2) seeding the compound; (3) causing a phase change in the pharmaceutical compound to a second phase of a desired polymorphic form; and (4) wherein the mean particle size of the particles is less than 7 &mgr;m.

  本发明提供了一种制备具有多晶型和尺寸控制的药物化合物颗粒的方法，该方法包括以下步骤：(1)提供第一相中的药物化合物；(2)播种该化合物；(3)使药物化合物发生相变，变成所需多晶型的第二相；(4)其中颗粒的平均粒度小于7&mgr;m。
• PREPARATION OF SUBMICRON SIZED PARTICLES WITH POLYMORPH CONTROL AND NEW POLYMORPH OF ITRACONAZOLE
  申请人：BAXTER INTERNATIONAL INC.

  公开号：EP1534239A2

  公开（公告）日：2005-06-01
• [EN] PREPARATION OF SUBMICRON SIZED PARTICLES WITH POLYMORPH CONTROL AND NEW POLYMORPH OF ITRACONAZOLE<br/>[FR] PREPARATION DE PARTICULES SUBMICRONIQUES AVEC REGULATION POLYMORPHIQUE ET NOUVEAU POLYMORPHE D'ITRACONAZOLE
  申请人：BAXTER INT

  公开号：WO2004054500A2

  公开（公告）日：2004-07-01

  The present invention provides a method of preparing particles with polymorph and size control of a pharmaceutical compound, the method including the steps of: (1) providing pharmaceutical compound in a first phase; (2) seeding the compound; (3) causing a phase change in the pharmaceutical compound to a second phase of a desired polymorphic form; and (4) wherein the mean particle size of the particles is less than 7µm. The present invention further provides a polymorphic form of itraconazole.