5-(3-methyl-5-oxo-4H-pyrazol-1-yl)pentanoic acid | 1093127-87-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-(3-methyl-5-oxo-4H-pyrazol-1-yl)pentanoic acid
• CAS: 1093127-87-7
• 化学式: C₉H₁₄N₂O₃
• 分子量: 198.222
• InChiKey: DHNNVWKZGYINKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  70
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-溴戊酸 、 3-甲基-2-吡唑啉-5-酮 以 1,4-二氧六环 为溶剂， 反应 48.0h， 生成 5-(3-methyl-5-oxo-4H-pyrazol-1-yl)pentanoic acid
  参考文献：
  名称：

  Methods and Compositions for Modulating P300/CBP Activity

  摘要：

  本发明涉及一种识别调节p300/CBP活性的化合物的方法。该发明的化合物是通过设计或筛选结合至新鉴定的赖氨酸-CoA抑制剂结合位点、L1环、电负性口袋或电负性槽的p300/CBP的HAT结构域的至少一个氨基酸残基的化合物来识别，并测试该化合物调节p300/CBP活性的能力。还提供了用于预防或治疗与p300/CBP相关的疾病或紊乱的组合物和方法，以及一种生产半合成HAT结构域的方法。

  公开号：

  US20100216853A1

文献信息

• Dye sensitized photographic imaging system
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0269397A2

  公开（公告）日：1988-06-01

  A photographic imaging system is disclosed comprised of a hardenable organic component containing ethylenic unsaturation sites and capable of imagewise modulating mobility as a function of addition at the sites of ethylenic unsaturation, coinitiators for ethylenic addition and, optionally, an imaging dye or a precursor thereof. The coinitiators include an azinium salt activator and a photosensitizer which is a dye exhibiting a reduction potential which in relation to that of said ionized azinium salt activator is at most 0.1 volt more posi­tive, with the further proviso that, when the photo­sensitizer is a keto dye having its principal absorp­tion peak at a wavelength shorter than 550 nm, it exhibits when excited by imaging radiation an inter­system crossing efficiency to a triplet state of less than 10 percent.

  本发明公开了一种照相成像系统，该系统由含有乙烯不饱和位点的可硬化有机成分、乙烯不饱和位点的加成函数、用于乙烯加成的辅助引发剂以及可选的成像染料或其前体组成。 辅助引发剂包括唑盐活化剂和光敏剂，光敏剂是一种染料，其还原电位与所述电离唑盐活化剂的还原电位相比至多正0.1伏，但进一步的条件是，当光敏剂是一种酮染料时，其主吸收峰的波长短于550纳米，在成像辐射的激发下，其到三重态的系统间交叉效率小于10%。
• Enhanced imaging composition containing an azinium activator
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0269398A2

  公开（公告）日：1988-06-01

  An imaging composition is disclosed com­prised of an organic component containing ethylenic unsaturation sites and capable of selective hardening by addition at the sites of ethylenic unsaturation, an azinium salt activator, a photosensitizer having a reduction potential which in relation to the reduc­tion potential of the azinium salt activator is at most 0.1 volt more positive, and an image enhancing amount of benzene substituted with an electron dona­ting amino group and one or more groups capable of imparting a net Hammett sigma value electron with­drawing characteristic of at least +0.20 volt to said benzene ring.

  本发明公开了一种成像组合物，该组合物由含有乙烯不饱和位点并能通过在乙烯不饱和位点上的加成而选择性硬化的有机组分、唑盐活化剂、具有相对于唑盐活化剂的还原电位至多正 0.1 伏的还原电位的光敏剂、以及被供电子氨基和一个或多个能赋予净哈密特西格玛值电子撤回特性至少+0.20 伏的净哈密特西格玛值电子撤回特性的基团取代的苯的图像增强量组成。1伏特的光敏剂，以及用一个电子供体氨基和一个或多个能赋予所述苯环至少+0.20伏特的净哈密特西格玛值电子撤回特性的基团取代的苯的图像增强量。
• Electroluminescent device with modified thin film luminescent zone
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0281381A2

  公开（公告）日：1988-09-07

  An electroluminescent device is disclosed having a luminescent zone of less than one µm in thickness comprised of an organic host material capa­ble of sustaining hole-electron recombination and a fluorescent material capable of emitting light in response to energy released by hole-electron recombi­nation.

  本发明公开了一种电致发光器件，该器件具有厚度小于 1 微米的发光区，发光区由能够维持空穴-电子重组的有机主材料和能够响应空穴-电子重组释放的能量而发光的荧光材料组成。
• An optical article containing a transmission medium exhibiting a high level of second order polarization susceptibility
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0313475A2

  公开（公告）日：1989-04-26

  An optical article is disclosed containing, for the transmission of electromagnetic radiation, a medium exhibiting a second order polarization susceptibility greater than 10⁻⁹ electrostatic units comprised of polar aligned noncentrosymmetric molecular dipoles having an electron donor moiety linked through a conjugated π bonding system to an electron acceptor moiety to permit oscillation of the molecular dipole between a ground state exhibiting a first dipole moment and an excited state exhibiting a differing dipole moment. The molecular dipoles are held in polar alignment by a crosslinked polymeric binder.

  本发明公开了一种用于传输电磁辐射的光学产品，该产品含有一种介质，该介质显示出大于 10-𠞙 静电单位的二阶偏振电感，该介质由极性排列的非中心对称分子偶极子组成，该分子偶极子具有一个电子供体分子，该电子供体分子通过共轭 π 键系统与一个电子受体分子相连，从而允许分子偶极子在显示第一偶极矩的基态和显示不同偶极矩的激发态之间摆动。分子偶极子通过交联聚合物粘合剂保持极性排列。
• Novel benzofuran dyes
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0341567A2

  公开（公告）日：1989-11-15

  A 6-tertiary amino-2-(Z=CH-)benzofuran dye is disclosed, where Z represents the atoms providing an electron withdrawing group and a conjugated methine linkage completing a resonant dye chromophore including the 6-tertiary amino group as an electron donor and the electron withdrawing group as an electron acceptor. The dyes are formed by condensing a 6-tertiary amino-2-formylbenzofuran with an electron withdrawing dye nucleus precursor containing an active methyl or methylene site. The dyes exhibit bathochromically shifted absorption peaks.

  本发明公开了一种 6-叔氨基-2-(Z=CH-)苯并呋喃染料，其中 Z 代表提供电子撤回基团和共轭甲基连接的原子，完成共振染料发色团，包括作为电子供体的 6-叔氨基和作为电子受体的电子撤回基团。这些染料是由 6-叔氨基-2-甲酰基苯并呋喃与含有活性甲基或亚甲基位点的电子汲取染料核前驱体缩合而成。这些染料表现出浴色偏移吸收峰。