Gymnamide | 913089-60-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Gymnamide
• 英文别名: (2E,4E,6R)-4,6-dimethyldodeca-2,4-dienamide
• CAS: 913089-60-8
• 化学式: C₁₄H₂₅NO
• 分子量: 223.359
• InChiKey: SQTPXUBCYVVRHH-FHYDJSHKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Gymnamide 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 1.5h， 以2.5 mg的产率得到Ethyl (2E,4E,6R)-4,6-dimethyl-2,4-dodecadienoic acid
  参考文献：
  名称：

  Gymnastatins F−H, Cytostatic Metabolites from the Sponge-Derived Fungus Gymnascella dankaliensis

  摘要：

  Gymnastatins F - H (2-4) and gymnamide ( 5) have been isolated from the mycelial MeOH extract of the Halichondria sponge-derived fungus Gymnascella dankaliensis. Their stereostructures have been established on the basis of spectroscopic analyses using 1D and 2D NMR techniques. The stereochemistry of gymnastatin H ( 4) was determined by its synthesis. Among these compounds, gymnastatins F ( 2) and G ( 3) possess a unique bicyclo[3.3.1] nonane ring as natural products, and they were found to exhibit potent growth inhibition against the P388 cancer cell line.

  DOI：

  10.1021/np0600189

文献信息

• [EN] ANTITUMORAL COMPOUNDS<br/>[FR] COMPOSÉS ANTICANCÉREUX
  申请人：PHARMA MAR SA

  公开号：WO2010149688A2

  公开（公告）日：2010-12-29

  A compound of general formula (I), wherein Y, W, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and the dashed lines take various meanings, for use in the treatment of cancer.
• Gymnastatins F−H, Cytostatic Metabolites from the Sponge-Derived Fungus <i>Gymnascella dankaliensis</i>
  作者：Taro Amagata、Katsuhiko Minoura、Atsushi Numata

  DOI：10.1021/np0600189

  日期：2006.10.1

  Gymnastatins F - H (2-4) and gymnamide ( 5) have been isolated from the mycelial MeOH extract of the Halichondria sponge-derived fungus Gymnascella dankaliensis. Their stereostructures have been established on the basis of spectroscopic analyses using 1D and 2D NMR techniques. The stereochemistry of gymnastatin H ( 4) was determined by its synthesis. Among these compounds, gymnastatins F ( 2) and G ( 3) possess a unique bicyclo[3.3.1] nonane ring as natural products, and they were found to exhibit potent growth inhibition against the P388 cancer cell line.