N-benzoyl-L-pyroglutamic acid | 80687-79-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-benzoyl-L-pyroglutamic acid
• 英文别名: N-benzoyl-(S)-pyroglutamic acid；1-Benzoyl-5-oxo-L-proline；(2S)-1-benzoyl-5-oxopyrrolidine-2-carboxylic acid
• CAS: 80687-79-2
• 化学式: C₁₂H₁₁NO₄
• 分子量: 233.224
• InChiKey: BQJAOYFZRGTLGB-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  74.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-benzoyl-L-pyroglutamic acid 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 44.0h， 生成
  参考文献：
  名称：

  A general method for the asymmetric synthesis of both enantiomers of 1-substituted 1,2,3,4-tetrahydro-β-carbolines employing pyroglutamic acid derivatives as chiral auxiliaries

  摘要：

  9-(S)-Pyroglutaminyl-beta-carbolines were allowed to react with a nucleophile (allyltributyltin or a silyl enol ether) in the presence of 2,2,2-trichloroethyl chloroformate to give 1,2-addition products in good yields and high diastereoselectivity. The chiral auxiliary at N-9 was readily removed by a mild hydrolysis. The same chiral source afforded both enantiomers by simply altering a protecting group of the amide nitrogen. That is, (S)-pyroglutaminyl groups which had an N-alkyl group afforded the (S) isomer, whereas the ones having an N-acyl group produced the (R) isomer of the addition products. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(03)00420-4
• 作为产物：
  描述：

  tert-butyl N-benzoyl-(S)-pyroglutamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以90%的产率得到N-benzoyl-L-pyroglutamic acid
  参考文献：
  名称：

  A general method for the asymmetric synthesis of both enantiomers of 1-substituted 1,2,3,4-tetrahydro-β-carbolines employing pyroglutamic acid derivatives as chiral auxiliaries

  摘要：

  9-(S)-Pyroglutaminyl-beta-carbolines were allowed to react with a nucleophile (allyltributyltin or a silyl enol ether) in the presence of 2,2,2-trichloroethyl chloroformate to give 1,2-addition products in good yields and high diastereoselectivity. The chiral auxiliary at N-9 was readily removed by a mild hydrolysis. The same chiral source afforded both enantiomers by simply altering a protecting group of the amide nitrogen. That is, (S)-pyroglutaminyl groups which had an N-alkyl group afforded the (S) isomer, whereas the ones having an N-acyl group produced the (R) isomer of the addition products. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(03)00420-4

文献信息

• COMPOUNDS AND METHODS TO INHIBIT OR AUGMENT AN INFLAMMATORY RESPONSE
  申请人：Grainger J. David

  公开号：US20080045557A1

  公开（公告）日：2008-02-21

  Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided.

  提供了分离和纯化的趋化因子肽、变体及其衍生物，以及趋化因子肽类似物。
• METHODS TO INHIBIT OR AUGMENT AN INFLAMMATORY RESPONSE
  申请人：Grainger David J.

  公开号：US20120065401A1

  公开（公告）日：2012-03-15

  Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided.

  本发明提供了分离和纯化的趋化因子肽、变体和衍生物，以及趋化因子肽类似物。
• Detergent additive composition.
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0659876A2

  公开（公告）日：1995-06-28

  Detergent Additive compositions are disclosed in which a peroxyacid bleach precursor in the form of a substrate particulate having a mean specific area in the range of 0.05 to 0.9 m2/g, is coated with a solid particulate organic acid compound of median particle size <450 micrometers, so as to give a Coating Index value (CI) in the range of from 0.01 to 9. A process for making the additive compositions and detergent products containing them are also disclosed.

  本发明公开了一种洗涤剂添加剂组合物，在这种组合物中，以平均比面积在 0.05 至 0.9 m2/g 之间的基质微粒形式存在的过氧酸漂白剂前体被中值粒径小于 450 微米的固体微粒有机酸化合物包覆，从而使包覆指数值（CI）在 0.01 至 9 之间。此外，还公开了制造添加剂组合物和含有添加剂组合物的洗涤剂产品的工艺。
• Bleaching compositions
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0682105A2

  公开（公告）日：1995-11-15

  There is provided a bleaching composition containing (a) a non Mn(II) compound transition metal containing bleach catalyst; (b) an oxygen bleach; and (c) a corrosion inhibitor compound preferably selected from a paraffin oil and benzotriazole, and combinations thereof.

  提供了一种漂白组合物，其中含有 (a) 含有漂白催化剂的非锰(II)化合物过渡金属； (b) 氧漂白剂；和 (c) 一种缓蚀剂化合物，最好选自石蜡油和苯并三唑及其组合。
• Detergent compositions
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0690122A2

  公开（公告）日：1996-01-03

  There is provided a bleaching composition containing (a) an oxygen-releasing bleaching agent as a source of available oxygen; and (b) a non-paraffin oil organic silver coating agent In one aspect the rate of release of available oxygen is carefully controlled such that the available oxygen is completely released from the composition in a time interval of from 3.5 minutes to 10.0 minutes. In another aspect the composition contains (c) an additional corrosion inhibtor compound.

  提供了一种漂白组合物，其中含有 (a) 作为可用氧源的释氧漂白剂；和 (b) 非石蜡油有机银涂层剂 在一个方面，可利用氧的释放速度受到严格控制，使可利用氧在 3.5 分钟至 10.0 分钟的时间间隔内从组合物中完全释放出来。在另一方面，该组合物含有 (c) 附加的缓蚀剂化合物。