N-[(3s,5s,7s)-adamantan-1-yl]-N-phenylhydroxylamine | 31463-30-6

• 分子结构分类: 有机化合物 - 苯类化合物 - N-苯基羟胺
• 英文名称: N-[(3s,5s,7s)-adamantan-1-yl]-N-phenylhydroxylamine
• 英文别名: N--N-phenyl-hydroxylamin；N-(1-adamantyl)-N-phenylhydroxylamine
• CAS: 31463-30-6
• 化学式: C₁₆H₂₁NO
• 分子量: 243.349
• InChiKey: XXSVIPOBCRNJBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(1-金刚烷基)羟胺 在 盐酸 、 sodium dichromate 作用下， 以 乙醚 为溶剂， 反应 2.0h， 生成 N-[(3s,5s,7s)-adamantan-1-yl]-N-phenylhydroxylamine
  参考文献：
  名称：

  Stetter,H.; Smulders,E., Chemische Berichte, 1971, vol. 104, p. 917 - 923

  摘要：

  DOI：

文献信息

• Photoredox Synthesis of Arylhydroxylamines from Carboxylic Acids and Nitrosoarenes
  作者：Nadeem Sheikh、Daniele Leonori、Jacob Davies、Lucrezia Angelini、Mohammed Alkhalifah、Laia Sanz

  DOI：10.1055/s-0036-1591744

  日期：2018.2

  direct conversion of carboxylic acids into the corresponding alkylhydroxylamines using organo-photoredox catalysis is reported. The process relies in the generation of alkyl radicals via photoinduced oxidation-decarboxylation and their following reaction with nitrosoarenes. We have successfully applied this method to the late-stage modification of complex and biologically active acids and applied it in

  作为Bürgenstock专栏2017年有机化学中的未来之星的一部分发布 抽象的 羟胺存在于生物活性化合物中，并用作制备含氮分子的基础。此处报道了使用有机光氧化还原催化将羧酸直接转化为相应的烷基羟胺的方法。该方法依赖于通过光诱导的氧化-脱羧作用及其随后与亚硝基芳烃的反应来产生烷基。我们已成功地将此方法应用于复杂的生物活性酸的后期修饰，并将其应用于新型自由基级联过程。 羟胺存在于生物活性化合物中，并用作制备含氮分子的基础。此处报道了使用有机光氧化还原催化将羧酸直接转化为相应的烷基羟胺的方法。该方法依赖于通过光诱导的氧化-脱羧作用及其随后与亚硝基芳烃的反应来产生烷基。我们已成功地将此方法应用于复杂的生物活性酸的后期修饰，并将其应用于新型自由基级联过程。
• TARGETED NITROXIDE AGENTS
  申请人：Wipf Peter

  公开号：US20100035869A1

  公开（公告）日：2010-02-11

  Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

  本文提供了一种对自由基清除有用的组合物和相关方法，具有特定选择性作用于线粒体。这些化合物包括一个连接到线粒体靶向基团的亚硝基含有基团。这些化合物可以交联成二聚体而不丧失活性。本文还提供了一种用于预防、缓解和治疗辐射引起的损伤的方法。该方法包括向患者输送一种如本文所述的化合物，以有效地预防、缓解或治疗辐射引起的损伤。
• TOPICAL FORMULATIONS OF TARGETED NITROXIDE AGENTS
  申请人：Falo, JR. Louis D.

  公开号：US20120207687A1

  公开（公告）日：2012-08-16

  A method for preventing or treating skin damage in a radiotherapy subject, comprising topically administering to the subject a composition that includes a therapeutically effective amount at least one targeted nitroxide agent and at least one additional ingredient.

  一种用于预防或治疗放疗受试者皮肤损伤的方法，包括将至少一种靶向亚硝酰胺试剂和至少一种其他成分的治疗有效剂量的组合物局部施用于受试者的皮肤。
• USE OF TARGETED NITROXIDE AGENTS IN PREVENTING, MITIGATING AND TREATING RADIATION INJURY
  申请人：Wipf Peter

  公开号：US20110172214A1

  公开（公告）日：2011-07-14

  Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

  本文提供了一种有用于自由基清除的组合物和相关方法，特别是对线粒体的选择性。该化合物包括连接到线粒体靶向基团的亚硝基含有基团。该化合物可以交联成二聚体而不失去活性。本文还提供了一种方法，用于预防、缓解和治疗放射性损伤。该方法包括将上述所述的化合物以有效的剂量和用药方案输送给患者，以预防、缓解或治疗放射性损伤。
• USE OF MITOCHONDRIA-TARGETED ELECTRON SCAVENGERS AS ANTI-INFLAMMATORY AGENTS
  申请人：Fink Mitchell P.

  公开号：US20090042808A1

  公开（公告）日：2009-02-12

  Provided herein are methods for using mitochondria-targeted electron scavengers as anti-inflammatory agents. The mitochondria-targeted electron scavenger comprises a free radical-scavenging group covalently linked to a mitochondria-targeting group derived from a hemigramicidin moiety. The mitochondria-targeted electron scavenger can be used to treat medical conditions associated with acute or chronic inflammation.