3,4-dichloro-N-phenylaniline | 116631-92-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4-dichloro-N-phenylaniline
• CAS: 116631-92-6
• 化学式: C₁₂H₉Cl₂N
• 分子量: 238.116
• InChiKey: AWSLRBVHZDHBCA-UHFFFAOYSA-N

物化性质

• 熔点：
  150 °C
• 沸点：
  346.0±32.0 °C(Predicted)
• 密度：
  1.327±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,4-dichloro-N-phenylaniline 在 盐酸 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 9.0h， 生成 (3,4-dichlorophenyl)phenylpyrrolidin-3-ylamine dihydrochloride
  参考文献：
  名称：

  WO2006/121218

  摘要：

  公开号：
• 作为产物：
  描述：

  邻氯苯甲酸钾 在 异戊醇 、 铜 作用下， 生成 3,4-dichloro-N-phenylaniline
  参考文献：
  名称：

  XXXIX.-10-Chloro-5：10-dihydrophenarsazine及其衍生物。第十四部分氯代衍生物

  摘要：

  DOI：

  10.1039/jr9310000294

文献信息

• Synthesis of Di(hetero)arylamines from Nitrosoarenes and Boronic Acids: A General, Mild, and Transition-Metal-Free Coupling
  作者：Silvia Roscales、Aurelio G. Csákÿ

  DOI：10.1021/acs.orglett.8b00473

  日期：2018.3.16

  The synthesis of di(hetero)arylamines by a transition-metal-free cross-coupling between nitrosoarenes and boronic acids is reported. The procedure is experimentally simple, fast, mild, and scalable and has a wide functional group tolerance, including carbonyls, nitro, halogens, free OH and NH groups. It also permits the synthesis of sterically hindered compounds.

  据报道，通过亚硝基芳烃和硼酸之间的无过渡金属交叉偶联来合成二（杂）芳基胺。该方法实验上简单，快速，温和且可扩展，并且具有宽泛的官能团耐受性，包括羰基，硝基，卤素，游离的OH和NH基团。它还允许合成位阻化合物。
• Straightforward access to novel indolo[2,3-<i>b</i>]indoles <i>via</i> aerobic copper-catalyzed [3+2] annulation of diarylamines and indoles
  作者：Taoyuan Liang、Lingzhen Gong、He Zhao、Huanfeng Jiang、Min Zhang

  DOI：10.1039/d0cc00178c

  日期：——

  Herein, we report an unprecedented aerobic copper-catalyzed [3+2] annulation reaction of diarylamines with indoles, which allows direct access to novel 2-diarylaminoindolo[2,3-b]indoles, a class of potential photoelectric device molecules. The developed transformation proceeds with broad substrate scope, good functional group tolerance, high chemo-selectivity, and no need for pre-preparation of specific

  在本文中，我们报道了前所未有的需氧铜催化的二芳基胺与吲哚的[3 + 2]环化反应，该反应可直接使用新颖的2-二芳基氨基吲哚[2,3-b]吲哚，一类潜在的光电器件分子。所开发的转化过程具有广泛的底物范围，良好的官能团耐受性，高化学选择性，并且无需预先制备特定的试剂，这为难于分离的所需产物的多样化和原子经济合成提供了一条实用的途径。用常规方法准备。
• Copper immobilized at a covalent organic framework: an efficient and recyclable heterogeneous catalyst for the Chan–Lam coupling reaction of aryl boronic acids and amines
  作者：Yi Han、Mo Zhang、Ya-Qing Zhang、Zhan-Hui Zhang

  DOI：10.1039/c8gc02611d

  日期：——

  inexpensive reagents and was employed as an effective support for heterogeneous copper. It was demonstrated that the obtained Cu@PI-COF is a highly active heterogeneous catalyst which can effectively promote the Chan–Lam coupling reaction of aryl boronic acids and amines in an open flask without the aid of any base or additive. In addition, the catalyst could be readily recovered from the reaction mixture

  具有高热稳定性和化学稳定性的聚酰亚胺共价有机骨架（PI-COF）可以很容易地从市售和廉价的试剂中制备，并被用作异质铜的有效载体。结果表明，所获得的Cu @ PI-COF是一种高活性的非均相催化剂，可以在不使用任何碱或添加剂的情况下，有效地促进开放烧瓶中芳基硼酸和胺的Chan-Lam偶联反应。另外，可以通过简单的过滤容易地从反应混合物中回收催化剂，并重复使用至少八个循环，而没有结构和催化活性的任何可观察到的变化。
• N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS
  申请人：Kurimura Muneaki

  公开号：US20090088406A1

  公开（公告）日：2009-04-02

  The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R 101 and R 102 are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.

  本发明提供了一种吡咯烷化合物，其一般式为（1），或其盐，其中R101和R102分别是苯基或吡啶基，苯基或吡啶基可以具有一个或多个卤原子和低碳基团，可选地取代一个或多个卤原子等。本发明的吡咯烷化合物或其盐可用于制备具有更广泛治疗谱并能够在短期内展现足够治疗效果的药物制剂。
• N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US08084442B2

  公开（公告）日：2011-12-27

  The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R101 and R102 are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.

  本发明提供了一种吡咯烷化合物通式（1）或其盐，其中R101和R102各自独立地是苯基或吡啶基，所述苯基或吡啶基可以具有一个或多个卤素原子和选择性地取代一个或多个卤素原子的较低烷基基团等取代基。本发明的吡咯烷化合物或其盐可用于制备具有更广泛治疗谱和能够在短期内展现足够治疗效果的制药配制物。