bicyclic tetramethylbisurea | 106780-29-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: bicyclic tetramethylbisurea
• 英文别名: 2,4,6,8-tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione；1,3,4,6-tetramethyltetrahydro-imidazo[4,5-d]imidazole-5-one；tetramethylglycoluril；mebikar；1,3,4,6-tetramethyl-(3ar,6ac)-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione；1,3,4,6-Tetramethyl-(3ar,6ac)-tetrahydro-imidazo[4,5-d]imidazol-2,5-dion
• CAS: 106780-29-4
• 化学式: C₈H₁₄N₄O₂
• 分子量: 198.225
• InChiKey: XIUUSFJTJXFNGH-OLQVQODUSA-N

物化性质

• 沸点：
  362.2±42.0 °C(Predicted)
• 密度：
  1.237±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.37
• 重原子数：
  14.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  47.1
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  bicyclic tetramethylbisurea 在 草酰氯 、 碘 、 三乙胺 作用下， 以 甲苯 、 乙腈 为溶剂， 反应 20.5h， 生成
  参考文献：
  名称：

  氧化还原化学和具有大体积双环胍基的芳香族化合物的第 10 族金属配合物

  摘要：

  活化的双环四甲基双脲与 1,2-二氨基苯或 1,2,4,5-四氨基苯之间的反应提供了双环胍基官能化的新芳香族化合物。进行质子化和氧化还原反应以获得有关这些新胍化学性质的信息。它们在单核和双核 10 族金属（Ni、Pd 和 Pt）配合物中用作螯合配体，这对于催化应用可能很有趣。Ni 配合物的初步实验表明，在烯烃低聚反应中具有中等活性，主要产生 C6 烃。

  DOI：

  10.1002/ejic.201100479
• 作为产物：
  描述：

  草酸醛 、 1,3-二甲基脲 在 盐酸 作用下， 以 甲醇 、 水 为溶剂， 以56%的产率得到bicyclic tetramethylbisurea
  参考文献：
  名称：

  氧化还原化学和具有大体积双环胍基的芳香族化合物的第 10 族金属配合物

  摘要：

  活化的双环四甲基双脲与 1,2-二氨基苯或 1,2,4,5-四氨基苯之间的反应提供了双环胍基官能化的新芳香族化合物。进行质子化和氧化还原反应以获得有关这些新胍化学性质的信息。它们在单核和双核 10 族金属（Ni、Pd 和 Pt）配合物中用作螯合配体，这对于催化应用可能很有趣。Ni 配合物的初步实验表明，在烯烃低聚反应中具有中等活性，主要产生 C6 烃。

  DOI：

  10.1002/ejic.201100479

文献信息

• CUCURBITURIL-BASED HYDROGELS
  申请人：CAMBRIDGE ENTERPRISE LIMITED

  公开号：US20150110772A1

  公开（公告）日：2015-04-23

  The invention provides hydrogel, wherein the hydrogel has a supramolecular cross-linked network obtainable or obtained from the complexation of an aqueous composition including a host, such as cucurbituril, and one or more polymers having suitable guest functionality. One or more polymers in the aqueous composition may have a molecular weight of 50 kDa or more, such as 200 kDa or more. The hydrogel may hold a component, such as a therapeutic compound or a biological molecule. The hydrogels are suitable for use in medicine.

  该发明提供了一种水凝胶，其中该水凝胶具有可从包括主体（如西瓜环状化合物）和具有适当客体功能的一种或多种聚合物的水性组合物的络合获得或获得的超分子交联网络。水性组合物中的一种或多种聚合物的分子量可以达到50 kDa或更高，例如200 kDa或更高。水凝胶可以容纳组分，例如治疗化合物或生物分子。这种水凝胶适用于医学。
• Imidazoimidazoles. I. The Reaction of Ureas With Glyoxal. Tetrahydroimidazo[4,5-d]imidazole-2,5-diones^1,2
  作者：Jay Nematollahi、Roger Ketcham

  DOI：10.1021/jo01044a055

  日期：1963.9
• SUPRAMOLECULAR CAPSULES
  申请人：Scherman Oren Alexander

  公开号：US20140170214A1

  公开（公告）日：2014-06-19

  Provided is a capsule having a shell of material that is a supramolecular cross-linked network. The network is formed from a host-guest complexation of cucurbituril (the host) and one or more building blocks comprising suitable guest functionality. The complex non-covalently crosslinks the building block and/or non-covalently links the building block to another building block thereby forming the supramolecular cross-linked network. The capsules are obtained or obtainable by the complexation of a composition comprising cucurbituril and one or more building blocks having suitable cucurbituril guest functionality thereby to form a supramolecular cross-linked network.
• PLASMONIC JUNCTIONS FOR SURFACE-ENHANCED SPECTROSCOPY
  申请人：Taylor Richard William

  公开号：US20140113382A1

  公开（公告）日：2014-04-24

  The invention relates to the use of a construct for the detection of an analyte using surface enhanced spectroscopic techniques. The construct includes linked surfaces, where the link is formed by a linker providing a fixed inter-surface separation between the linked surfaces, wherein the linker is a linking compound, and at least one of the surfaces is the surface of a nanoparticle. The linking compound is suitable for interacting with the analyte. The linking compound may be a cucurbituril. The surface enhanced spectroscopic technique may be surface enhanced Raman spectroscopy (SERS).
• NESTED SUPRAMOLECULAR CAPSULES
  申请人：CAMBRIDGE ENTERPRISE LIMITED

  公开号：US20150368407A1

  公开（公告）日：2015-12-24

  A nested capsule having a first capsule held within a second capsule. Each of the first and second capsules has a shell that is a supramolecular cross-linked network, such as a cucurbituril supramolecular cross-linked network. Each capsule shell is obtained or is obtainable from the complexation of a composition including a host, such as cucurbituril, and one or more building blocks having suitable guest functionality for the host, thereby to form a supramolecular cross-linked network. The nested capsules are suitable for delivering and selectively releasing an encapsulant at a location.