N-cyclohexyl-isopropanesulfonamide | 69200-46-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: N-cyclohexyl-isopropanesulfonamide
• 英文别名: N-cyclohexylpropane-2-sulfonamide
• CAS: 69200-46-0
• 化学式: C₉H₁₉NO₂S
• 分子量: 205.321
• InChiKey: WDKYUMYXXKGAON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-cyclohexyl-isopropanesulfonamide 、 1,1,2,2-四氯乙烷磺酸苯基氯化物 生成 N-cyclohexyl-N-(1,1,2,2-tetrachloroethylthio)-isopropanesulfonamide
  参考文献：
  名称：

  CHAN, D. C. K.;WHIPP, A. A.

  摘要：

  DOI：

文献信息

• Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
  申请人：Rodgers D. James

  公开号：US20070135461A1

  公开（公告）日：2007-06-14

  The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

  本发明提供了杂环取代的吡咯并[2,3-b]吡啶和杂环取代的吡咯并[2,3-b]嘧啶，可以调节雅努斯激酶的活性，并且在治疗与雅努斯激酶活性相关的疾病中具有用处，例如免疫相关疾病、皮肤疾病、髓增生性疾病、癌症和其他疾病。
• HEPATITIS B ANTIVIRAL AGENTS
  申请人：ENANTA PHARMACEUTICALS, INC.

  公开号：US20170355701A1

  公开（公告）日：2017-12-14

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明公开了式（I）的化合物或其药学上可接受的盐：这些化合物抑制由乙型肝炎病毒（HBV）编码的蛋白质或干扰乙型肝炎病毒的生命周期功能，并且还可用作抗病毒剂。本发明还涉及包括上述化合物的药物组合物，用于给患有HBV感染的受试者使用。该发明还涉及通过给予包含本发明化合物的药物组合物来治疗受试者的HBV感染的方法。
• Mite and mite-ovicidal compositions
  申请人：Chevron Research Company

  公开号：US04107332A1

  公开（公告）日：1978-08-15

  Mites and mite eggs are killed with an N-tetrachloroethylthio-substituted sulfonamide of the formula ##STR1## wherein R is alkyl, alkenyl, cycloalkyl or aryl, R.sup.1 is alkyl, alkenyl, cycloalkyl or aryl, and R.sup.2 is tetrachloroethyl, with the proviso that R and R.sup.1 are not both cycloalkyl or aryl.

  螨虫和螨卵可以被一种化学式为##STR1##的N-四氯乙硫代磺胺类物质杀死，其中R为烷基、烯基、环烷基或芳基，R.sup.1为烷基、烯基、环烷基或芳基，R.sup.2为四氯乙基，但要注意R和R.sup.1不能同时为环烷基或芳基。
• HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS
  申请人：Rodgers James D.

  公开号：US20090181959A1

  公开（公告）日：2009-07-16

  The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

  本发明提供了杂环取代的吡咯并[2,3-b]吡啶和杂环取代的吡咯并[2,3-b]嘧啶，可调节Janus激酶的活性，并可用于治疗与Janus激酶活性相关的疾病，包括免疫相关疾病、皮肤疾病、髓系增生性疾病、癌症和其他疾病。
• Quaternary ammonium salt catalyzed preparation of sulfonamides
  申请人：Chevron Research Company

  公开号：US04208348A1

  公开（公告）日：1980-06-17

  Mites and mite eggs are killed with an N-tetrachloroethylthio-substituted sulfonamide of the formula ##STR1## wherein R is alkyl, alkenyl, cycloalkyl or aryl, R.sup.1 is alkyl, alkenyl, cycloalkyl or aryl, and R.sup.2 is tetrachloroethyl, with the proviso that R and R.sup.1 are not both cycloalkyl or aryl prepared using an acid acceptor and a catalytic amount of a quaternary ammonium salt.

  螨和螨卵可以被一种式子为##STR1##的N-四氯乙硫基取代磺酰胺杀死，其中R为烷基、烯基、环烷基或芳基，R.sup.1为烷基、烯基、环烷基或芳基，R.sup.2为四氯乙基，条件是R和R.sup.1不同时为环烷基或芳基，该杀虫剂是通过使用酸受体和四级铵盐的催化剂量制备的。