BIM-23056 | 150155-61-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: BIM-23056
• 英文别名: BIM 23056；D-Phe-Phe-Tyr-D-Trp-Lys-Val-Phe-3-(2-naphthalenyl)-D-Ala-NH2；D-Phe-Phe-Tyr-D-Trp-Lys-Val-Phe-D-Nal-NH2；D-Alaninamide, D-phenylalanyl-L-phenylalanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-phenylalanyl-3-(2-naphthalenyl)-；(2S)-6-amino-N-[(2S)-1-[[(2S)-1-[[(2R)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanamide
• CAS: 150155-61-6
• 化学式: C₇₁H₈₁N₁₁O₉
• 分子量: 1232.49
• InChiKey: VPTPBEUWKCLZGU-OOSWLFMASA-N

物化性质

• 沸点：
  1544.6±65.0 °C(Predicted)
• 密度：
  1.271±0.06 g/cm3(Predicted)
• 溶解度：
  在水中的溶解度>1mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  91
• 可旋转键数：
  32
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  335
• 氢给体数：
  12
• 氢受体数：
  11

安全信息

• 安全说明：
  Sx."

制备方法与用途

生物活性

BIM 23056 是一种线性八肽，是一种有效的 sst3 和 sst5 生长抑素受体拮抗剂，其 Ki 值分别为 10.8 和 5.7。

体外研究

BIM 23056 在体外的研究中表现出以下 Ki 值：sst1 的 Ki 值为 142，sst4 的 Ki 值为 16.6，而 sst2 的 Ki 值大于 1000。

文献信息

• Use of somatostatin or one of its analogues for preparing a medicament intended to regulate the ovarian follicular reserve in non-menopausal women
  申请人：Gougeon Alain

  公开号：US20070155659A1

  公开（公告）日：2007-07-05

  The invention primarily relates to the use of somatostatin or one of the agonistic analogs thereof for producing a medicament serving to regulate the ovarian follicular reserve and, in particular, to reduce the depletion of the ovarian follicular reserve over time in non-menopausal women or to the use of an antagonistic analog of somatostatin for producing a medicament serving to accelerate the start of growing of quiescent follicles in non-menopausal women. The invention also relates to in vitro applications of somatostatin and of agonistic and antagonistic analogs thereof.
• USE OF SOMATOSTATIN OR ONE OF ITS ANALOGUES FOR PREPARING A MEDICAMENT INTENDED TO REGULATE THE OVARIAN FOLLICULAR RESERVE IN NON-MENOPAUSAL WOMEN
  申请人：GOUGEON Alain

  公开号：US20100152102A1

  公开（公告）日：2010-06-17

  The invention primarily relates to the use of somatostatin or one of the agonistic analogs thereof for producing a medicament serving to regulate the ovarian follicular reserve and, in particular, to reduce the depletion of the ovarian follicular reserve over time in non-menopausal women or to the use of an antagonistic analog of somatostatin for producing a medicament serving to accelerate the start of growing of quiescent follicles in non-menopausal women. The invention also relates to in vitro applications of somatostatin and of agonistic and antagonistic analogs thereof.
• US7648961B2
  申请人：——

  公开号：US7648961B2

  公开（公告）日：2010-01-19