ethyl (2E)-2-[2-(diphenylphosphino) benzylidene]hydrazinecarboxylate | 1428740-56-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl (2E)-2-[2-(diphenylphosphino) benzylidene]hydrazinecarboxylate
• 英文别名: ethyl (2E)-2-[2-(diphenylphosphino)benzylidene]hydrazinecarboxylate；ethyl N-[(E)-(2-diphenylphosphanylphenyl)methylideneamino]carbamate
• CAS: 1428740-56-0
• 化学式: C₂₂H₂₁N₂O₂P
• 分子量: 376.395
• InChiKey: DYXXBQFSLRNZHU-HAVVHWLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  potassium tetrachloropalladate(II) 、 ethyl (2E)-2-[2-(diphenylphosphino) benzylidene]hydrazinecarboxylate 以 乙醇 、 水 为溶剂， 反应 2.0h， 以73%的产率得到
  参考文献：
  名称：

  Synthesis, characterization and antimicrobial activity of Pd(II) and Fe(III) complexes with ethyl (2E)-2-[2-(diphenylphosphino)benzylidene]hydrazinecarboxylate

  摘要：

  DOI：

  10.1016/j.poly.2014.01.022
• 作为产物：
  描述：

  2-二苯基膦苯甲醛 、 肼基甲酸乙酯 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以83%的产率得到ethyl (2E)-2-[2-(diphenylphosphino) benzylidene]hydrazinecarboxylate
  参考文献：
  名称：

  Synthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate

  摘要：

  A cobalt(III) complex with the condensation derivative of 2-(diphenylphosphino) benzaldehyde and ethyl carbazate was synthesized. X-ray crystal structure was determined for both the ligand and the complex. In the cobalt(III) complex two deprotonated ligand molecules coordinate the metal atom in a distorted octahedral geometry by chelation through the PNO donor system formed by the phosphorus, the imine nitrogen and the carbonyl oxygen. The complex showed a moderate antibacterial activity and a strong cytotoxic activity, stronger than cisplatin. Based on cell cycle progression, apoptotic assays, spectroscopic and electrophoretic studies, it was shown that high cytotoxicity and moderate potential of induction of apoptosis are not consequence of interactions with DNA. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.09.043

文献信息

• Synthesis, characterization and biological activity of three square-planar complexes of Ni(II) with ethyl (2E)-2-[2-(diphenylphosphino)benzylidene]hydrazinecarboxylate and monodentate pseudohalides
  作者：Milica Milenković、Alessia Bacchi、Giulia Cantoni、Jovana Vilipić、Dušan Sladić、Miroslava Vujčić、Nevenka Gligorijević、Katarina Jovanović、Siniša Radulović、Katarina Anđelković

  DOI：10.1016/j.ejmech.2013.07.039

  日期：2013.10

  Three square-planar complexes of nickel(II) with the tridentate condensation derivative of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate, and monodentate pseudohalides, have been synthesized. Their crystal structures have been determined. All the complexes showed a significant antifungal activity, while only the azido complex displayed antibacterial activity. All the complexes were cytotoxic to a panel of six tumor cell lines, the azido complex showing a similar activity as cisplatin to leukemia cell line K562 and lower toxicity to normal MRC-5 cells than that anticancer agent. The complexes interfered with cell cycle of tumor cells and induced plasmid DNA cleavage. (C) 2013 Elsevier Masson SAS. All rights reserved.
• Synthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate
  作者：Milica Milenković、Alessia Bacchi、Giulia Cantoni、Siniša Radulović、Nevenka Gligorijević、Sandra Aranđelović、Dušan Sladić、Miroslava Vujčić、Dragana Mitić、Katarina Anđelković

  DOI：10.1016/j.ica.2012.09.043

  日期：2013.1

  A cobalt(III) complex with the condensation derivative of 2-(diphenylphosphino) benzaldehyde and ethyl carbazate was synthesized. X-ray crystal structure was determined for both the ligand and the complex. In the cobalt(III) complex two deprotonated ligand molecules coordinate the metal atom in a distorted octahedral geometry by chelation through the PNO donor system formed by the phosphorus, the imine nitrogen and the carbonyl oxygen. The complex showed a moderate antibacterial activity and a strong cytotoxic activity, stronger than cisplatin. Based on cell cycle progression, apoptotic assays, spectroscopic and electrophoretic studies, it was shown that high cytotoxicity and moderate potential of induction of apoptosis are not consequence of interactions with DNA. (C) 2012 Elsevier B. V. All rights reserved.
• Synthesis, characterization and antimicrobial activity of Pd(II) and Fe(III) complexes with ethyl (2E)-2-[2-(diphenylphosphino)benzylidene]hydrazinecarboxylate
  作者：Milica Milenković、Giulia Cantoni、Alessia Bacchi、Vojislav Spasojević、Marina Milenković、Dušan Sladić、Natalija Krstić、Katarina Anđelković

  DOI：10.1016/j.poly.2014.01.022

  日期：2014.9