2-methoxy-3-phenyl-1-propene | 26473-60-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methoxy-3-phenyl-1-propene
• 英文别名: 2-Methoxy-3-phenylpropen；3-Phenyl-2-methoxypropene；2-methoxyprop-2-enylbenzene
• CAS: 26473-60-9
• 化学式: C₁₀H₁₂O
• 分子量: 148.205
• InChiKey: AAIKVOZOPVNPRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-methoxy-3-phenyl-1-propene 在 三氟乙酸 作用下， 生成 (2-甲氧基丙-1-烯-1-基)苯
  参考文献：
  名称：

  Gaudry,M.; Marquet,A., Bulletin de la Societe Chimique de France, 1969, p. 4178 - 4182

  摘要：

  DOI：
• 作为产物：
  描述：

  phenylacetone dimethylketal 在 三异丁基铝 作用下， 以 正己烷 、 二氯甲烷 为溶剂， 反应 5.0h， 以76%的产率得到2-methoxy-3-phenyl-1-propene
  参考文献：
  名称：

  Triisobutylaluminun (TIBA) as a reagent to convert 2,2-dimethoxyalkanes to 2-methoxy-1-alkenes

  摘要：

  Methanol ketals undergo methanol elimination by reaction with triisobutylaluminum to yield the corresponding less substituted 2-methoxyolefins; the experimental conditions are compatible with the Presence of other functional groups. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01141-8

文献信息

• Product Studies and Laser Flash Photolysis on Alkyl Radicals Containing Two Different β-Leaving Groups Are Consonant with the Formation of an Olefin Cation Radical
  作者：Brian C. Bales、John H. Horner、Xianhai Huang、Martin Newcomb、David Crich、Marc M. Greenberg

  DOI：10.1021/ja0042938

  日期：2001.4.1

  hydrogen atom transfer to the oxygen of the olefin cation radical, followed by deprotonation. Laser flash photolysis experiments indicate that reaction between 5 and 1,4-cyclohexadiene occurs with a rate constant of approximately 6 x 10(5) M(-1) s(-1). 2,2-Dimethoxy-1-phenylpropane (18) is observed as a minor product. Laser flash photolysis experiments place an upper limit on methanol trapping of 5

  1-溴-2-甲氧基-1-苯基丙-2-基 (3) 和 2-甲氧基-1-苯基-1-二苯基磷酸丙-2-基 (4) 是在混合物中各自 PTOC 前体的连续光解下生成的乙腈和甲醇。自由基在β-位进行取代基的杂裂断裂以产生烯烃阳离子自由基(5)。Z-2-甲氧基-1-苯基丙烯 (15) 是在 1,4- 环己二烯存在下形成的主要产物，据信是由氢原子转移到烯烃阳离子自由基的氧上，然后去质子化的结果。激光闪光光解实验表明 5 和 1,4-环己二烯之间的反应以大约 6 x 10(5) M(-1) s(-1) 的速率常数发生。观察到 2,2-二甲氧基-1-苯基丙烷 (18) 作为次要产物。激光闪光光解实验在 k <1 x 10(3) M(-1) s(-1) 处将甲醇捕获的上限设置为 5，并且不提供除 5 以外的反应性中间体的形成的任何证据。使用两种含有不同离去基团的 PTOC 前体生成一个共同的烯烃阳离子自由基使
• Pd-catalyzed Oxidative Cross-coupling of Alkyl Chromium(0) Fischer Carbene Complexes with Organoboronic Acids
  作者：Kang Wang、Jinghui Yang、Xingqi Yao、Jianbo Wang

  DOI：10.1002/asia.201801278

  日期：2018.11.2

  Alkyl chromium(0) carbene complexes have been explored as the cross‐coupling partners in the palladium‐catalyzed reaction with aryl or alkenyl boronic acids. This coupling reaction displays the versatile reactivities of alkyl chromium(0) carbenes under palladium catalysis. Mechanistically, this transformation is proposed to involve deprotonation of the alkyl chromium carbene substrate to generate a

  烷基铬（0）卡宾配合物已被探索为钯与芳基或烯基硼酸催化的交叉偶联伙伴。此偶联反应显示了钯催化下烷基铬（0）卡宾的通用反应性。从机理上讲，提出这种转变涉及烷基铬卡宾底物的去质子化以产生乙烯基铬阴离子中间体，该中间体经历金属转移成有机钯物质并还原消除。
• Methylenation of Esters with Bis(iodozincio)methane-TiCl₂-TMEDA System
  作者：Seijiro Matsubara、Katsumi Ukai、Tsuyoshi Mizuno、Kiitiro Utimoto

  DOI：10.1246/cl.1999.825

  日期：1999.8

  Methylenation of ester carbonyl group with bis(iodozincio)methane was examined: a use of TiCl2 and amine as mediators facilitated the reaction to give vinyl ethers in good yields.

  研究了酯羰基与双(碘锌)甲烷的甲基化：使用 TiCl 2 和胺作为介体促进了反应，以良好的产率得到乙烯基醚。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• Synthesis of Sulfur-containing Heterocycles by Thermolysis of a-Alkylthio-N-aziridinylimines
  作者：Sunggak Kim、Chang Mook Cho

  DOI：10.3987/com-94-6816

  日期：——

  Thermolysis of alpha-alkylthio substituted N-aziridinylimines in refluxing toluene gave various structurally different sulfur-containing heterocycles in high yields.

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