2-ethyl-4-methylethoxybenzene | 101144-95-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-ethyl-4-methylethoxybenzene
• 英文别名: 2-ethyl-4-methyl-phenetole；2-Aethyl-4-methyl-phenetol；1-Ethoxy-2-ethyl-4-methylbenzene
• CAS: 101144-95-0
• 化学式: C₁₁H₁₆O
• 分子量: 164.247
• InChiKey: ZLOMELWDZKPRLF-UHFFFAOYSA-N

物化性质

• 沸点：
  223.1±9.0 °C(Predicted)
• 密度：
  0.917±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-ethyl-4-methylethoxybenzene 在 正丁基锂 、 乙醚 作用下， 生成 1-(2-ethoxy-3-ethyl-5-methyl-benzyl)-2-methyl-piperidine
  参考文献：
  名称：

  1-benzylpiperidine compounds

  摘要：

  公开号：

  US02589205A1
• 作为产物：
  描述：

  1-(2-ethoxy-5-methyl-phenyl)-ethanone 在 copper oxide-chromium oxide 作用下， 200.0 ℃ 、9.81 MPa 条件下， 生成 2-ethyl-4-methylethoxybenzene
  参考文献：
  名称：

  1-benzylpiperidine compounds

  摘要：

  公开号：

  US02589205A1

文献信息

• [EN] INHIBITING OTUB1<br/>[FR] INHIBITION DE L'OTUB1
  申请人：INTEGRAL EARLY DISCOVERY INC

  公开号：WO2020223551A1

  公开（公告）日：2020-11-05

  The present disclosure is directed to compounds of formulas (I) - (VII), which are useful as modulators of OTUB1. The compounds are further useful in the inhibition of OTUB1 and the treatment of diseases or disorders associated with the inhibition of OTUB1. For instance, the disclosure is concerned with compounds and compositions for inhibition of OTUB1, methods of treating diseases associated with the inhibition of OTUB1 (e.g., inflammatory diseases like irritable bowel disease and Lupus), and methods of synthesis of these compounds.

  本公开涉及的是公式(I)-(VII)的化合物，它们可用作OTUB1的调节剂。这些化合物还可用于抑制OTUB1和治疗与抑制OTUB1相关的疾病或疾病。例如，本公开涉及用于抑制OTUB1的化合物和组合物，治疗与抑制OTUB1相关的疾病的方法（例如，炎症性疾病，如肠易激综合征和红斑狼疮），以及这些化合物的合成方法。
• Cetp Inhibitors
  申请人：Ali Amjad

  公开号：US20070225365A1

  公开（公告）日：2007-09-27

  Compounds of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula 1, A 1 and A 2 are each an aromatic ring, a 5-6-membered heterocyclic ring, an aromatic ring fused to a heterocyclic ring, a phenyl ring fused to a heterocyclic ring, or a cycloalkyl ring.

  公式I的化合物，包括化合物的药物可接受盐，是CETP抑制剂，可用于提高HDL-胆固醇，降低LDL-胆固醇，并用于治疗或预防动脉硬化。在公式1的化合物中，A1和A2分别是芳香环，5-6成员杂环环，芳香环与杂环环融合，苯环与杂环环融合或环状烷基。
• CETP INHIBITORS
  申请人：Ali Amjad

  公开号：US20100249024A1

  公开（公告）日：2010-09-30

  Compounds of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula 1, A 1 and A2 are each an aromatic ring, a 5-6-membered heterocyclic ring, an aromatic ring fused to a heterocyclic ring, a phenyl ring fused to a heterocyclic ring, or a cycloalkyl ring.

  公式I的化合物，包括该化合物的药用可接受盐，是CETP抑制剂，可用于提高高密度脂蛋白胆固醇，降低低密度脂蛋白胆固醇，并用于治疗或预防动脉硬化。在公式I的化合物中，A1和A2分别是芳香环、5-6元杂环、芳香环与杂环融合、苯环与杂环融合或环状烷基环。
• BRIDGED BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS
  申请人：Singh Rajinder

  公开号：US20110105512A1

  公开（公告）日：2011-05-05

  Bridged bicyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase AxI. Methods of using the compounds in treating diseases or conditions associated with AxI activity are also disclosed.

  本发明公开了桥接的双环杂芳基取代的三唑类化合物以及含有该化合物的制药组合物，用于抑制受体蛋白酪氨酸激酶AxI的活性。本发明还公开了使用该化合物治疗与AxI活性相关的疾病或病况的方法。
• NOVOLAC-BASED EPOXY COMPOUND, PRODUCTION METHOD FOR SAME, COMPOSITION AND CURED ARTICLE COMPRISING SAME, AND USE FOR SAME
  申请人：Korea Institute of Industrial Technology

  公开号：EP2871182A1

  公开（公告）日：2015-05-13

  The present invention relates to: a novolac-based epoxy compound having an alkoxysilyl group, which compound does not require a separate silane coupling agent and exhibits a low coefficient of thermal expansion (CTE) and high glass transition in a synergistic effect, when forming a composite material by curing; a production method for same; and an epoxy composition and cured article comprising same. According to one mode of embodiment of the present invention, provided are: a novolac-based epoxy compound having an alkoxysilyl group of chemical formula I-1 to I-4; a production method for a novolac-based epoxy compound having an alkoxysilyl group of chemical formula I-1 to 1-4 by means of the epoxidation, alkenylation and alkoxysilylation of a novolac-based epoxy compound; a production method for a novolac-based epoxy compound having an alkoxysilyl group of chemical formula I-1 to 1-4 by means of the epoxidation and alkoxysilylation of a novolac-based epoxy compound; and an epoxy composition comprising a novolac-based epoxy compound having an alkoxysilyl group of chemical formula I-1 to I-4; and also provided is a cured article of same. A cured article constituted by a composite article of the composition comprising the novolac-based epoxy compound having an alkoxysilyl group of a novel kind according to the present invention has improved chemical bonding efficiency when forming an epoxy composite by means of chemical bonding between the alkoxysilyl groups of the epoxy compound having alkoxysilyl groups, not to mention chemical bonding of a filler with the alkoxysilyl groups in the epoxy compound. Consequently, a low CTE and high glass transition temperature are exhibited.

  本发明涉及：一种具有烷氧基硅烷基团的酚醛基环氧化合物，该化合物不需要单独的硅烷偶联剂，并且在通过固化形成复合材料时，在协同效应中表现出低热膨胀系数（CTE）和高玻璃化转变；一种生产方法；以及一种环氧组合物和包含该环氧组合物的固化制品。根据本发明的一种实施方式，提供了一种具有化学式 I-1 至 I-4 烷氧基硅烷基的酚醛基环氧化合物； 一种通过酚醛基环氧化合物的环氧化、烯基化和烷氧基硅烷化生产具有化学式 I-1 至 1-4 烷氧基硅烷基的酚醛基环氧化合物的方法；一种通过酚醛基环氧化合物的环氧化反应和烷氧基硅烷化反应制备具有化学式 I-1 至 1-4 烷氧基硅烷基的酚醛基环氧化合物的生产方法；以及一种环氧组合物，该组合物包含具有化学式 I-1 至 I-4 烷氧基硅烷基的酚醛基环氧化合物；此外还提供了相同的固化物。由包含根据本发明的具有新型烷氧基硅基的酚醛基环氧化合物的组合物构成的复合材料制成的固化制品，在通过具有烷氧基硅基的环氧化合物的烷氧基硅基之间的化学键合形成环氧复合材料时，具有更好的化学键合效率，更不用说填料与环氧化合物中的烷氧基硅基的化学键合。因此，该复合材料具有较低的热膨胀系数（CTE）和较高的玻璃化转变温度。