N'-diphenoxyphosphoryl-2-phenylethanimidamide | 1085853-20-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-diphenoxyphosphoryl-2-phenylethanimidamide
• CAS: 1085853-20-8
• 化学式: C₂₀H₁₉N₂O₃P
• 分子量: 366.356
• InChiKey: SDPARFDRTYLLCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  叠氮磷酸二苯酯 、 苯乙炔 在 copper(l) iodide 、 氯化铵 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以39%的产率得到N'-diphenoxyphosphoryl-2-phenylethanimidamide
  参考文献：
  名称：

  Synthetic Utility of Ammonium Salts in a Cu-Catalyzed Three-Component Reaction as a Facile Coupling Partner

  摘要：

  Ammonium salts were found to be a convenient and inexpensive reagent in the Cu-catalyzed three-component reaction with terminal alkynes and sulfonyl or phosphoryl azides leading to N-unprotected amidines. Thus obtained amidines bearing 2-bromobenzenesulfonyl moiety were efficiently cyclized by the Cu-catalyzed intramolecular N-arylation to give an important pharmacophore skeleton of 2H-1,2,4-benzothiadiazine 1,1-dioxides. Conveniently, two tandem catalytic procedures could be readily operated in one pot.

  DOI：

  10.1021/jo802014g

文献信息

• Synthetic Utility of Ammonium Salts in a Cu-Catalyzed Three-Component Reaction as a Facile Coupling Partner
  作者：Jinho Kim、S. Yunmi Lee、Junseung Lee、Youngkyu Do、Sukbok Chang

  DOI：10.1021/jo802014g

  日期：2008.12.5

  Ammonium salts were found to be a convenient and inexpensive reagent in the Cu-catalyzed three-component reaction with terminal alkynes and sulfonyl or phosphoryl azides leading to N-unprotected amidines. Thus obtained amidines bearing 2-bromobenzenesulfonyl moiety were efficiently cyclized by the Cu-catalyzed intramolecular N-arylation to give an important pharmacophore skeleton of 2H-1,2,4-benzothiadiazine 1,1-dioxides. Conveniently, two tandem catalytic procedures could be readily operated in one pot.