N-diphenoxyphosphoryl-2-phenyl-N'-propylethanimidamide | 1207731-55-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-diphenoxyphosphoryl-2-phenyl-N'-propylethanimidamide
• CAS: 1207731-55-2
• 化学式: C₂₃H₂₅N₂O₃P
• 分子量: 408.437
• InChiKey: HIWQEICQGBWLKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  59.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  正丙胺 、 叠氮磷酸二苯酯 、 苯乙炔 在 copper(l) iodide 作用下， 以 四氢呋喃 为溶剂， 生成 N-diphenoxyphosphoryl-2-phenyl-N'-propylethanimidamide
  参考文献：
  名称：

  Synthesis and SAR of sulfonyl- and phosphoryl amidine compounds as anti-resorptive agents

  摘要：

  Sulfonyl amidines (1) and phosphoryl amidines (2), which were efficiently synthesized via a Cu-catalyzed one pot reaction, showed potent anti-bone resorptive activity in vitro. Structure activity relationship studies led to the identification of numerous osteoclast differentiation inhibitors. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.11.104

文献信息

• Synthesis and SAR of sulfonyl- and phosphoryl amidine compounds as anti-resorptive agents
  作者：Myung Yun Lee、Myung Hee Kim、Jinho Kim、Seok Hwan Kim、Bum Tae Kim、In Howa Jeong、Sukbok Chang、Seong Hwan Kim、Sung-Youn Chang

  DOI：10.1016/j.bmcl.2009.11.104

  日期：2010.1

  Sulfonyl amidines (1) and phosphoryl amidines (2), which were efficiently synthesized via a Cu-catalyzed one pot reaction, showed potent anti-bone resorptive activity in vitro. Structure activity relationship studies led to the identification of numerous osteoclast differentiation inhibitors. (C) 2009 Elsevier Ltd. All rights reserved.