1,11-dimethyldibenzo[d,f][1,3]dioxepin | 260395-80-0

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 1,11-dimethyldibenzo[d,f][1,3]dioxepin
• 英文别名: 1,11-Dimethylbenzo[d][1,3]benzodioxepine
• CAS: 260395-80-0
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: XQQJCSNXHGAWEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,11-dimethyldibenzo[d,f][1,3]dioxepin 在 二氯乙基铝 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以60%的产率得到5-methyl-2,4-cyclohexadienone-6-spiro-3'-(4'-methyl-2',3'-dihydrobenzo[b]furan)
  参考文献：
  名称：

  Synthesis of the Spirocyclic Cyclohexadienone Ring System of the Schiarisanrins

  摘要：

  [GRAPHICS]Studies on the synthesis of the spirocyclic cyclohexadienone ring system 2 of the schiarisanrin family of natural products 1 are described and were based on the Lewis acid-promoted C-alkylation of the corresponding phenolic precursor.

  DOI：

  10.1021/ol991238z
• 作为产物：
  描述：

  2-甲氧基-6-甲基苯胺 在 盐酸 、 copper bronze 、 三溴化硼 、 sodium hydride 、 sodium nitrite 作用下， 以 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 1,11-dimethyldibenzo[d,f][1,3]dioxepin
  参考文献：
  名称：

  Synthesis of the Spirocyclic Cyclohexadienone Ring System of the Schiarisanrins

  摘要：

  [GRAPHICS]Studies on the synthesis of the spirocyclic cyclohexadienone ring system 2 of the schiarisanrin family of natural products 1 are described and were based on the Lewis acid-promoted C-alkylation of the corresponding phenolic precursor.

  DOI：

  10.1021/ol991238z

文献信息

• Process For The Preparation Of Enantiomerically Enriched Beta Amino Acid Derivatives
  申请人：Xiao Yi

  公开号：US20080058522A1

  公开（公告）日：2008-03-06

  The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives wherein the amino group is unprotected. The product chiral beta amino acid derivatives are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of an amine-unprotected prochiral beta-amino acrylic acid or derivative thereof in the presence of a rhodium metal precursor complexed with a chiral mono- or bisphosphine ligand.

  本发明涉及一种高效制备非保护氨基的对映富集的β-氨基酸衍生物的方法。该产物手性的β-氨基酸衍生物在生物活性分子的不对称合成中有用。该方法包括在手性单或双膦配体络合的铑金属前体存在下，对未保护氨基的丙烯酸β-氨基酸或其衍生物进行对映选择性的氢化。
• Process for Making Substituted Piperidines
  申请人：Nelson D. Todd

  公开号：US20080086006A1

  公开（公告）日：2008-04-10

  The present invention provides a process for the preparation of substituted piperidines which comprises an asymmetric hydrogenation of vinyl fluoride in the presence of a metal precursor complexed with a chiral mono- or biphosphine ligand.
• Cycloolefin Phosphine Ligands and Their Use in Catalysis
  申请人：Kadyrov Renat

  公开号：US20080306264A1

  公开（公告）日：2008-12-11

  The present invention concerns novel bidentante optionally N-containing P-ligands of general Formula (I) embracing a two-ring-system and processes for synthesizing them, transition metal complexes of these compounds and their use as catalysts.
• PROCESS FOR PREPARING CATIONIC RHODIUM COMPLEXES
  申请人：Nedden Hans Guenter

  公开号：US20100113256A1

  公开（公告）日：2010-05-06

  A process for the synthesis of a cationic rhodium complex comprises the steps of: (a) forming a mixture of a rhodium-diolefin-1,3-diketonate compound and a phosphorus ligand in a ketone solvent, (b) mixing an acid with the mixture to form a solution of the cationic rhodium complex, (c) evaporating at least a portion of the solvent from the solution, (d) optionally, treating the resulting complex with an ether, and (e) treating the resulting complex with an alcohol. The complex may be recovered and used as a catalyst, for example in hydrogenation reactions.
• US7495123B2
  申请人：——

  公开号：US7495123B2

  公开（公告）日：2009-02-24