2-(3,4,5-trimethoxyphenyl)-4,6-diphenylpyrimidine | 1529532-05-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(3,4,5-trimethoxyphenyl)-4,6-diphenylpyrimidine
• 英文别名: 4,6-diphenyl-2-(3,4,5-trimethoxyphenyl)pyrimidine；4,6-Diphenyl-2-(3,4,5-trimethoxyphenyl)pyrimidine
• CAS: 1529532-05-5
• 化学式: C₂₅H₂₂N₂O₃
• 分子量: 398.461
• InChiKey: OARQYTCGMHQTHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  53.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,4,5-三甲氧基苯甲醛 在 吡啶 、 碘 、 potassium carbonate 、 sodium hydroxide 作用下， 以 二氯甲烷 、 二甲基亚砜 、 叔丁醇 为溶剂， 反应 4.0h， 生成 2-(3,4,5-trimethoxyphenyl)-4,6-diphenylpyrimidine
  参考文献：
  名称：

  Efficient and Benign One-Pot Conversion of N-Tosyl-1,4,5,6-tetrahydropyrimidines to Pyrimidines via Tandem β-Elimination and Aromatization

  摘要：

  An efficient, mild, benign, and practical method for one-pot conversion of N-tosyl-1,4,5,6-tetrahydropyrimidines into pyrimidines is discussed in detail. In this method, N-tosyl-1,4,5,6-tetrahydropyrimidines are first prepared via N-tosylation of tetrahydropyrimidines with TsCl and then treated with 1.5 equivalents of NaOH in dimethylsulfoxide (DMSO) under air at 60 degrees C to afford corresponding pyrimidines in 70-95% yields via cascade -elimination and aromatization. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resources: Full experimental and spectral details.]

  DOI：

  10.1080/00397911.2013.764433

文献信息

• Novel multi-component syntheses of pyrimidines using β-CD in aqueous medium
  作者：Chowrasia Rakhi、Katla Ramesh、Mariana P. Darbem、Tabata A. Branquinho、Aline Rufino de Oliveira、Padma Sunitha Manjari、Nelson Luís C. Domingues

  DOI：10.1016/j.tetlet.2016.02.106

  日期：2016.4

  Using β-cyclodextrin (β-CD) as a catalyst pyrimidine derivatives were synthesized for the first time in aqueous medium. β-CD is a recyclable, inexpensive, economically viable, non-toxic, and readily available material. Various aldehydes were used with ammonium acetate, and 1,3-diketones to generate a series of pyrimidine derivatives in good to excellent yields.

  以β-环糊精（β-CD）为催化剂，在水介质中首次合成了嘧啶衍生物。β-CD是一种可回收，廉价，经济可行，无毒且易于获得的材料。各种醛与乙酸铵和1,3-二酮一起使用可生成一系列嘧啶衍生物，收率好至极好。