2-[2-[2-(1,3-Dioxoisoindol-2-yl)oxyethyl-methylamino]ethoxy]isoindole-1,3-dione | 1222450-69-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-[2-[2-(1,3-Dioxoisoindol-2-yl)oxyethyl-methylamino]ethoxy]isoindole-1,3-dione
• 英文别名: 2-[2-[2-(1,3-dioxoisoindol-2-yl)oxyethyl-methylamino]ethoxy]isoindole-1,3-dione
• CAS: 1222450-69-2
• 化学式: C₂₁H₁₉N₃O₆
• 分子量: 409.398
• InChiKey: RPKWOLGJSVTANA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  96.5
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-[2-[2-(1,3-Dioxoisoindol-2-yl)oxyethyl-methylamino]ethoxy]isoindole-1,3-dione 、 碘甲烷 反应 2.0h， 生成 2-((1,3-dioxoisoindolin-2-yl)oxy)-N-(2-((1,3-dioxoisoindolin-2-yl)oxy)ethyl)-N,N-dimethylethan-1-aminium iodide
  参考文献：
  名称：

  Nucleophilic cationization reagents

  摘要：

  Nucleophilic cationization reagents fitted with aminooxy groups are described. Practical syntheses of mono- and bis-aminooxy tetraalkylammonium iodides including N-hydroxyethyl-functionalized analogs are reported. An oximation example using one of the reagents is presented to illustrate their use in synthesis of cationic materials. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.01.094
• 作为产物：
  描述：

  N-羟基邻苯二甲酰亚胺 、 N-甲基二乙醇胺 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 以72%的产率得到2-[2-[2-(1,3-Dioxoisoindol-2-yl)oxyethyl-methylamino]ethoxy]isoindole-1,3-dione
  参考文献：
  名称：

  Nucleophilic cationization reagents

  摘要：

  Nucleophilic cationization reagents fitted with aminooxy groups are described. Practical syntheses of mono- and bis-aminooxy tetraalkylammonium iodides including N-hydroxyethyl-functionalized analogs are reported. An oximation example using one of the reagents is presented to illustrate their use in synthesis of cationic materials. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.01.094

文献信息

• Nucleophilic cationization reagents
  作者：Souvik Biswas、Xuan Huang、Wesley R. Badger、Michael H. Nantz

  DOI：10.1016/j.tetlet.2010.01.094

  日期：2010.3

  Nucleophilic cationization reagents fitted with aminooxy groups are described. Practical syntheses of mono- and bis-aminooxy tetraalkylammonium iodides including N-hydroxyethyl-functionalized analogs are reported. An oximation example using one of the reagents is presented to illustrate their use in synthesis of cationic materials. (C) 2010 Elsevier Ltd. All rights reserved.