Clebopride maleate | 74214-64-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Clebopride maleate
• 英文别名: 4-amino-N-(1-benzylpiperidin-4-yl)-5-chloro-2-methoxybenzamide;(Z)-but-2-enedioic acid
• CAS: 74214-64-5
• 化学式: C24H28ClN3O6
• 分子量: 489.9
• InChiKey: BCVIWCRZYPHHMQ-BTJKTKAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.04
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  142
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• METHODS AND COMPOSITIONS FOR TREATING INFECTION
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US20150238473A1

  公开（公告）日：2015-08-27

  Provided herein are compositions and methods for treating or preventing infection.

  本文提供了用于治疗或预防感染的组合物和方法。
• [EN] RADIOACTIVE SUBSTRATES FOR ALDEHYDE DEHYDROGENASE<br/>[FR] SUBSTRATS RADIOACTIFS POUR L'ALDÉHYDE DÉSHYDROGÉNASE
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2014145493A1

  公开（公告）日：2014-09-18

  A detectable substrate for aldehyde dehydrogenase (ALDH) can include a radiolabel. When acted upon by ALDH in an ALDH-expressing cell, e.g., cancer cells, the radiolabeled substrate accumulates in the ALDH-expressing cell. ALDH-expressing cells can be distinguished by the accumulated radioactivity. When combined with suitable imaging technique, the detectable substrate can be used for in vivo imaging of cancer cells.

  一种可检测的醛脱氢酶（ALDH）底物可以包含放射性标记。在ALDH表达细胞（例如癌细胞）中被ALDH作用时，放射性标记的底物会在ALDH表达细胞中积累。ALDH表达细胞可以通过积累的放射性活性来区分。结合适当的成像技术，可将可检测的底物用于体内癌细胞成像。
• [EN] RED FLUORESCENT ALDEHYDE DEHYDROGENASE (ALDH) SUBSTRATE<br/>[FR] SUBSTRAT D'ALDÉHYDE DÉSHYDROGÉNASE (ALDH) FLUORESCENT ROUGE
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2014130834A1

  公开（公告）日：2014-08-28

  A detectable substrate for aldehyde dehydrogenase (ALDH) can be used for selecting cells that express ALDH. The detectable substrate can have a fluorescent moiety that has an excitation wavelength, an emission wavelength, or both, that does not overlap with the excitation wavelength, emission wavelength, or both, of green fluorescent protein.

  一种可检测的乙醛脱氢酶(ALDH)底物可用于选择表达ALDH的细胞。该可检测的底物可以具有荧光基团，其激发波长、发射波长或两者都不重叠于绿色荧光蛋白的激发波长、发射波长或两者都不重叠。
• Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1787679A1

  公开（公告）日：2007-05-23

  The present invention refers to the use of compounds active on the sigma receptor for the production of a medicament for the treatment of diabetes-associated pain.

  本发明是指利用对 sigma 受体具有活性的化合物来生产治疗糖尿病相关疼痛的药物。
• Use of compounds binding to the sigma receptor for the treatment of metabolic syndrome
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1829534A1

  公开（公告）日：2007-09-05

  The present invention refers to the use of compounds binding to the sigma receptor for the treatment of metabolic syndrome.

  本发明是指使用与西格玛受体结合的化合物来治疗代谢综合征。