3-hydroxy-2-(4-pyridyl)pyridine | 103851-73-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-hydroxy-2-(4-pyridyl)pyridine
• 英文别名: [2,4'-Bipyridin]-3-ol；2-pyridin-4-ylpyridin-3-ol
• CAS: 103851-73-6
• 化学式: C₁₀H₈N₂O
• 分子量: 172.186
• InChiKey: HVQAGTOYIIZBNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-furyl 4-pyridyl ketone 在 ammonium hydroxide 作用下， 反应 5.0h， 以35%的产率得到3-hydroxy-2-(4-pyridyl)pyridine
  参考文献：
  名称：

  Synthesis of 2-heteroaryl-3-hydroxypyridines by ring expansion reactions of 2-acylfurans with ammonia

  摘要：

  描述了一种简单且多用途的合成2-杂芳基-3-羟基吡啶衍生物的方法，即在150°C下将2-酰基呋喃与氨进行一步反应。

  DOI：

  10.1039/b105228b

文献信息

• HETEROCYCLIC COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2982666A1

  公开（公告）日：2016-02-10

  The present invention relates to a compound represented by the formula (I), which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. In the formula (I), each symbol is as defined in the specification.

  本发明涉及一种由式（I）表示的化合物，它可作为预防或治疗癫痫、神经退行性疾病等的药物。在式 (I) 中，各符号如说明书中所定义。
• Bioisosteric prototype design of biaryl imidazolyl and triazolyl competitive histamine H2-receptor antagonists
  作者：Christopher A. Lipinski、John L. LaMattina、P. J. Oates

  DOI：10.1021/jm00161a005

  日期：1986.11

  The structural relationship of the competitive histamine H2-receptor antagonist 3-amino-5-(2-amino-4-pyridyl)-1,2,4-triazole (1) to the agonist histamine and to antagonists of the cimetidine type was explored by the design and synthesis of four series of bioisosterically designed prototypes. Biological data from these series was best interpreted as indicating a similarity between the imidazole moiety of histamine and cimetidine and the 2-amino-4-pyridyl moiety of 1. On the basis of this data, sequential replacement of 2-amino-4-pyridyl by 2-[(dimethylamino)methyl]-5-furyl and 2-guanidino-4-triazolyl moieties led to a structurally more potent series of biaryl histamine H2-receptor antagonists. The best of these, 2-methyl-4-(2-guanidino-4-thiazolyl)imidazole (29, CP-57,361-1) was 120 times more potent as a histamine H2-receptor antagonist than 1.
• LIPINSKI C. A.; LAMATTINA J. L.; OATES P. J., J. MED. CHEM., 29,(1986) N 11, 2154-2163
  作者：LIPINSKI C. A.、 LAMATTINA J. L.、 OATES P. J.

  DOI：——

  日期：——