2,4,5-trichlorophenyl phenoxyacetate | 17859-53-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4,5-trichlorophenyl phenoxyacetate
• 英文别名: 2,4,5-trichlorophenylphenoxyacetate；Phenoxyessigsaeure-<2.4.5-trichlor-phenyl>-ester；(2,4,5-trichlorophenyl) 2-phenoxyacetate
• CAS: 17859-53-9
• 化学式: C₁₄H₉Cl₃O₃
• 分子量: 331.583
• InChiKey: JNTRIYGIZHNYBS-UHFFFAOYSA-N

物化性质

• 沸点：
  456.7±45.0 °C(Predicted)
• 密度：
  1.433±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4,5-trichlorophenyl phenoxyacetate 在 ammonium hydroxide 、 三甲基氯硅烷 、 N,N-二异丙基乙胺 作用下， 以 吡啶 、 二氯甲烷 为溶剂， 反应 21.0h， 生成 5'-O-dimethoxytrityl-N²,N⁶-bis(phenoxyacetyl)-2,6-diaminopurine-2'-deoxyriboside 3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite
  参考文献：
  名称：

  Synthesis of Oligodeoxyribonucleotides Containing 2,6-Diaminopurine

  摘要：

  The preparation of a new protected derivative of 2,6-diaminopurine 2'-deoxyriboside carrying two phenoxyacetyl groups is described. The new derivative is useful to prepare oligonucleotides containing 2,6-diaminopurine and it is deprotected at the same time as the standard protecting groups of the natural bases.

  DOI：

  10.1080/15257779408013258
• 作为产物：
  描述：

  2,4,5-三氯苯酚 、 苯氧乙酰氯 以 吡啶 、 二氯甲烷 为溶剂， 反应 0.5h， 以82%的产率得到2,4,5-trichlorophenyl phenoxyacetate
  参考文献：
  名称：

  Synthesis of Oligodeoxyribonucleotides Containing 2,6-Diaminopurine

  摘要：

  The preparation of a new protected derivative of 2,6-diaminopurine 2'-deoxyriboside carrying two phenoxyacetyl groups is described. The new derivative is useful to prepare oligonucleotides containing 2,6-diaminopurine and it is deprotected at the same time as the standard protecting groups of the natural bases.

  DOI：

  10.1080/15257779408013258

文献信息

• Polypeptides. Part X. Variations of the tryptophyl position in the C-terminal tetrapeptide amide sequence of the gastrins
  作者：H. Gregory、J. S. Morley

  DOI：10.1039/j39680000910

  日期：——

  The synthesis is described of analogues of L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanine amide (the C-terminal sequence of the gastrins), and its N-benzyloxycarbonyl or N-t-butoxycarbonyl derivatives, wherein the tryptophyl residue has undergone replacement by glycyl, histidyl, lysyl, phenylalanyl, tyrosyl, 4-, 5- or 6-methyltryptophyl, Nα-methyltryptophyl, or 2- or 5-hydroxytryptophyl residues

  描述了L-色氨酸-L-甲硫酰基-L-天冬氨酰-L-苯丙氨酸酰胺（胃泌素的C-末端序列）及其N-苄氧羰基或N-叔丁氧羰基衍生物的类似物的合成，其中残余物具有由甘氨酰，组氨酰，赖氨酰，苯丙氨酰基，酪氨酰基经历更换，4-，5-或6- methyltryptophyl，ñ α -methyltryptophyl，或2-或5- hydroxytryptophyl残基，或以各种其它方式已被修改。
• Synthesis, Base Pairing, and Fluorescence Properties of Oligonucleotides Containing 1H-Pyrazolo[3,4-d]pyrimidin-6-amine (8-Aza-7-deazapurin-2-amine) as an Analogue of Purin-2-amine
  作者：Frank Seela、Georg Becher

  DOI：10.1002/(sici)1522-2675(20000510)83:5<928::aid-hlca928>3.0.co;2-5

  日期：2000.5.10

  less stable than those containing 2′-deoxyadenosine, while their CD spectra are rather different. The fluorescence of the nucleosides is strongly quenched (>95%) in single-stranded as well as in duplex DNA. The residual fluorescence was used to determine the melting profiles, which gave Tm values similar to those determined from the UV melting curves.

  分别合成 8-aza-7-deazapurin-2-amine (=1H-pyrazolo[3,4-d]pyrimidin) 的 N9- 和 N8-(β-D-2'-deoxyribonucleosides) 2 和 10 -6-胺）进行了描述。测定了 2 的荧光性质和 N-糖基键的稳定性，并分别与 purin-2-amine 和 7-deazapurin-2-amine 的 2'-脱氧核糖核苷 1 和 3 进行了比较。由核苷2制备亚磷酰胺14，合成寡核苷酸。含有化合物 1 或 2 的双链体比含有 2'-脱氧腺苷的双链体稍微不稳定，而它们的 CD 光谱则大不相同。核苷的荧光在单链和双链 DNA 中被强烈淬灭 (>95%)。残余荧光用于确定熔解曲线，
• Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses
  申请人：——

  公开号：US20030198982A1

  公开（公告）日：2003-10-23

  The present invention is in the field of nucleic acid binding compounds comprising 7-substituted 7-deaza-8aza-2,6-diamino-purine bases, compounds useful for the preparation of such compounds, various uses thereof and methods for the determination of nucleic acids using said compounds in the field of diagnostics.

  本发明涉及核酸结合化合物领域，包括7-取代7-脱氮-8-脱氮-2,6-二氨基嘌呤碱基的化合物，用于制备此类化合物的化合物，它们的各种用途以及在诊断领域中使用该化合物进行核酸测定的方法。
• Nucleic Acid Binding Compounds Containing Pyrazolo[3,4-D]Pyrimidine Analogues of Purin-2,6-Diamine and Their Uses
  申请人：Seela Frank

  公开号：US20110021365A1

  公开（公告）日：2011-01-27

  The present invention is in the field of nucleic acid binding compounds comprising 7-substituted 7-deaza-8aza-2,6-diamino-purine bases, compounds useful for the preparation of such compounds, various uses thereof and methods for the determination of nucleic acids using said compounds in the field of diagnostics.

  本发明涉及核酸结合化合物领域，包括7-取代7-脱氧-8-氮杂-2,6-二氨基嘌呤碱基的化合物，用于制备此类化合物的化合物，其各种用途以及在诊断领域中使用该化合物确定核酸的方法。
• NAGARAJAN, R.;SCHABEL, A. A.;OCCOLOWITZ, J. L.;COUNTER, F. T.;OTT, J. L., J. ANTIBIOTICS, 41,(1988) N 10, C. 1430-1438
  作者：NAGARAJAN, R.、SCHABEL, A. A.、OCCOLOWITZ, J. L.、COUNTER, F. T.、OTT, J. L.

  DOI：——

  日期：——