N,N'-di-m-fluorophenyl guanidine | 1216902-38-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-di-m-fluorophenyl guanidine
• 英文别名: 1,3-bis(3-fluorophenyl)guanidine；m-FDPhG；1,2-Bis(3-fluorophenyl)guanidine
• CAS: 1216902-38-3
• 化学式: C₁₃H₁₁F₂N₃
• 分子量: 247.247
• InChiKey: SSIOZLPQCSOLFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  间溴氟苯 、 硝酸胍 在 potassium phosphate 、 copper(l) iodide 、 肌氨酸 作用下， 以 乙腈 为溶剂， 反应 20.0h， 以85%的产率得到N,N'-di-m-fluorophenyl guanidine
  参考文献：
  名称：

  Synthesis of Symmetrical and Unsymmetrical N,N′-Diaryl Guanidines via Copper/N-Methylglycine-Catalyzed Arylation of Guanidine Nitrate

  摘要：

  CuI/N-methylglycine-catalyzed coupling reaction of guanidine nitrate with both aryl iodides and bromides takes place at 70-100 degrees C, affording symmetrical N,N'-diaryl guanidines with good to excellent yields. Unsymmetrical N,N'-diaryl guanidines can be assembled via monoarylation of guanidine nitrate with aryl iodides bearing a strong electron-withdrawing group and subsequent coupling with another aryl iodide.

  DOI：

  10.1021/jo300840x

文献信息

• Regenerable solvent mixtures for acid-gas separation
  申请人：Research Triangle Institute

  公开号：US10960345B2

  公开（公告）日：2021-03-30

  A solvent system for the removal of acid gases from mixed gas streams is provided. Also provided is a process for removing acid gases from mixed gas streams using the disclosed solvent systems. The solvent systems may be utilized within a gas processing system.

  提供了一种用于去除混合气体流中酸性气体的溶剂系统。此外，还提供了一种利用所公开的溶剂系统从混合气体流中去除酸性气体的工艺。该溶剂系统可在气体处理系统中使用。
• Copper-Catalyzed Guanidinylation of Aryl Iodides: The Formation of <i>N,N′</i>-Disubstituted Guanidines
  作者：Michelle Cortes-Salva、Be-Lan Nguyen、Javier Cuevas、Keith R. Pennypacker、Jon C. Antilla

  DOI：10.1021/ol1002175

  日期：2010.3.19

  A copper-catalyzed cross-coupling reaction of guanidine nitrate with aryl iodides was used for the formation of N,N'-disubstituted guanidines to be used as potential therapeutics for strokes. A relatively inexpensive commercially available guanidine salt and a series of aryl iodides together with copper iodide and N,N-diethylsalicylamide as an efficient catalyst/ligand system provided a simple diarylation procedure.
• Synthesis of Symmetrical and Unsymmetrical <i>N</i>,<i>N</i>′-Diaryl Guanidines via Copper/<i>N</i>-Methylglycine-Catalyzed Arylation of Guanidine Nitrate
  作者：Hui Xing、Ye Zhang、Yisheng Lai、Yongwen Jiang、Dawei Ma

  DOI：10.1021/jo300840x

  日期：2012.6.15

  CuI/N-methylglycine-catalyzed coupling reaction of guanidine nitrate with both aryl iodides and bromides takes place at 70-100 degrees C, affording symmetrical N,N'-diaryl guanidines with good to excellent yields. Unsymmetrical N,N'-diaryl guanidines can be assembled via monoarylation of guanidine nitrate with aryl iodides bearing a strong electron-withdrawing group and subsequent coupling with another aryl iodide.