4-bromo-3-ethyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole | 959755-70-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 4-bromo-3-ethyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole
• 英文别名: 4-bromo-3-ethyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazole；4-bromo-3-ethyl-1-(oxan-2-yl)pyrazole
• CAS: 959755-70-5
• 化学式: C₁₀H₁₅BrN₂O
• 分子量: 259.146
• InChiKey: GUTFWMXLZGFANI-UHFFFAOYSA-N

物化性质

• 沸点：
  355.0±42.0 °C(Predicted)
• 密度：
  1.52±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,4-二氢-2H-吡喃 、 4-溴-3-乙基-1H-吡唑 在 三氟乙酸 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 24.0h， 以97%的产率得到4-bromo-3-ethyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole
  参考文献：
  名称：

  WO2020079457A5

  摘要：

  公开号：

  WO2020079457A5

文献信息

• Triazolopyrazine compounds useful for the treatment of degenerative & inflammatory diseases
  申请人：Andrews Inglis Martin James

  公开号：US20080090818A1

  公开（公告）日：2008-04-17

  Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

  本发明揭示了一种Novel [1.2.4]triazolo[1,5-a]pyrazine化合物，其化学式如下：这些化合物可以制备成药物组成物，并可用于哺乳动物包括人类的预防和治疗多种疾病，例如，但不限于疼痛、炎症等。
• TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
  申请人：Andrews Martin James Inglis

  公开号：US20110178067A1

  公开（公告）日：2011-07-21

  Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

  揭示了一种Novel [1.2.4]三唑并[1,5-a]吡嗪化合物，其化学式如下：这些化合物可以制备为药物组合物，并可用于哺乳动物，包括人类的预防和治疗多种病症，例如疼痛、炎症等，但不限于此。
• TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES
  申请人：Andrews Martin James Inglis

  公开号：US20100298300A1

  公开（公告）日：2010-11-25

  Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

  本发明披露了一种具有以下公式表示的[1.2.4]三唑并[1,5-a]吡嗪化合物：这些化合物可以制备为药物组合物，并可用于预防和治疗哺乳动物包括人类的各种疾病，包括但不限于疼痛，炎症等。
• WO2007/138072
  申请人：——

  公开号：——

  公开（公告）日：——
• PYRAZOLE DERIVATIVES AS H4 ANTAGONIST COMPOUNDS
  申请人：Heptares Therapeutics Limited

  公开号：US20210300906A1

  公开（公告）日：2021-09-30

  The disclosures herein relate to novel compounds of formula (1): and salts thereof, wherein A; X; n; R 1 and R 2 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with H4 receptors.