7,15,23-Tribromo-25,26,27-tris(2-methoxyethoxymethoxy)-3,11,19-trioxatetracyclo[19.3.1.15,9.113,17]heptacosa-1(24),5,7,9(27),13(26),14,16,21(25),22-nonaene | 915374-11-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 7,15,23-Tribromo-25,26,27-tris(2-methoxyethoxymethoxy)-3,11,19-trioxatetracyclo[19.3.1.15,9.113,17]heptacosa-1(24),5,7,9(27),13(26),14,16,21(25),22-nonaene
• CAS: 915374-11-7
• 化学式: C₃₆H₄₅Br₃O₁₂
• 分子量: 909.458
• InChiKey: VPVOGPDUBORCQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  51
• 可旋转键数：
  18
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  111
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  7,15,23-Tribromo-25,26,27-tris(2-methoxyethoxymethoxy)-3,11,19-trioxatetracyclo[19.3.1.15,9.113,17]heptacosa-1(24),5,7,9(27),13(26),14,16,21(25),22-nonaene 在 四(三苯基膦)钯 盐酸 、 sodium carbonate 作用下， 以 甲醇 、 乙酸乙酯 、 甲苯 为溶剂， 生成 7,15,23-Tripyridin-3-yl-3,11,19-trioxatetracyclo[19.3.1.15,9.113,17]heptacosa-1(24),5,7,9(27),13(26),14,16,21(25),22-nonaene-25,26,27-triol
  参考文献：
  名称：

  Suzuki–Miyaura coupling on the three upper rims of hexahomotrioxacalix[3]arenes

  摘要：

  The efficient functionalization of three upper rims based on Suzuki-Miyaura coupling to temporarily lower rim-protected hexahomotrioxacalix[3]arenes was developed. After deprotection of the three protecting groups, the three upper rim-functionalized and lower rim-free hexahomotrioxacalix[3]arenes 5a-5m were synthesized. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.08.073
• 作为产物：
  描述：

  2-甲氧基乙氧基甲基氯 、 7,15,23-tribromo-2,3,10,11,18,19-hexahomo-3,11,19-trioxacalix[3]arene-25,26,27-triol 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以63%的产率得到7,15,23-Tribromo-25,26,27-tris(2-methoxyethoxymethoxy)-3,11,19-trioxatetracyclo[19.3.1.15,9.113,17]heptacosa-1(24),5,7,9(27),13(26),14,16,21(25),22-nonaene
  参考文献：
  名称：

  Suzuki–Miyaura coupling on the three upper rims of hexahomotrioxacalix[3]arenes

  摘要：

  The efficient functionalization of three upper rims based on Suzuki-Miyaura coupling to temporarily lower rim-protected hexahomotrioxacalix[3]arenes was developed. After deprotection of the three protecting groups, the three upper rim-functionalized and lower rim-free hexahomotrioxacalix[3]arenes 5a-5m were synthesized. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.08.073

文献信息

• Suzuki–Miyaura coupling on the three upper rims of hexahomotrioxacalix[3]arenes
  作者：Kazunori Tsubaki、Masahide Sakakibara、Yuki Nakatani、Takeo Kawabata

  DOI：10.1016/j.tet.2006.08.073

  日期：2006.10

  The efficient functionalization of three upper rims based on Suzuki-Miyaura coupling to temporarily lower rim-protected hexahomotrioxacalix[3]arenes was developed. After deprotection of the three protecting groups, the three upper rim-functionalized and lower rim-free hexahomotrioxacalix[3]arenes 5a-5m were synthesized. (c) 2006 Elsevier Ltd. All rights reserved.