ethyl(2-vinylphenyl)amine | 48115-98-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl(2-vinylphenyl)amine
• 英文别名: 2-ethenyl-N-ethylaniline
• CAS: 48115-98-6
• 化学式: C₁₀H₁₃N
• mdl: MFCD19225883
• 分子量: 147.22
• InChiKey: VRABELOLRVRYEK-UHFFFAOYSA-N

物化性质

• 沸点：
  249.5±19.0 °C(Predicted)
• 密度：
  0.972±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  ethyl(2-vinylphenyl)amine 在 正丁基锂 作用下， 以 甲苯 为溶剂， 反应 19.0h， 生成 1-ethyl-2-(2-(ethylthio)-6-methylphenyl)-1,2-dihydrobenzo[e][1,2]azaborinine
  参考文献：
  名称：

  Palladium‐Catalyzed Atroposelective Kinetic C−H Olefination and Allylation for the Synthesis of C−B Axial Chirality

  摘要：

  摘要 1,2-苯并氮硼烷的直接 C-H 官能化，尤其是不对称官能化，仍然是一个巨大的挑战。在此，我们报告了一种钯催化的 1,2-苯并氮硼烷的对映选择性 C-H 烯化和烯丙基化反应。这种不对称方法是一种动力学解析 (KR)，可提供各种 C-B 轴手性 2-芳基-1,2-苯并氮硼烷和 3-取代的 2-芳基-1,2-苯并氮硼烷，产量普遍较高，对映选择性极佳（选择性 (S) 因子高达 354）。通过对复杂分子的后期修饰、放大反应和应用，展示了这一反应的合成潜力。

  DOI：

  10.1002/anie.202313388
• 作为产物：
  描述：

  N-(2-bromophenyl)ethanimine 在 四(三苯基膦)钯 sodium tetrahydroborate 、 potassium carbonate 作用下， 以 甲醇 、 乙二醇二甲醚 、 水 为溶剂， 反应 20.0h， 生成 ethyl(2-vinylphenyl)amine
  参考文献：
  名称：

  Indole Synthesis by Controlled Carbolithiation of o-Aminostyrenes

  摘要：

  An effective synthesis of the functionalized indole ring system has been developed from substituted o-aminostyrene starting material. Our methodology involves a novel cascade reaction sequence of alkyllithium addition to the styrene double bond and subsequent trapping of the intermediate organolithium with a suitable electrophile, followed by an in situ ring closure and dehydration to generate the indole ring. This new reaction sequence allows for the introduction of molecular diversity at all positions on the indole scaffold. The procedure was shown to be successful with a range of both C and N substituents on the o-aminostyrenes. The reaction sequence was tolerant to the reactivity range of alkyllithiums such as tert-, sec-, and n-butyllithium. The electrophiles used were DMF, which generated indole products with C-2 unsubstituted, and nitriles, which incorporated the nitrile substituent at C-2. The o-aminostyrene starting materials were generated by a Pd-catalyzed cross-coupling reaction of a vinyl boronic acid equivalent with the readily available substituted o-bromoanilines.

  DOI：

  10.1021/jo048723e

文献信息

• Catalytic reduction of aromatic ring in aqueous medium
  申请人：King Fahd University of Petroleum and Minerals

  公开号：US10618878B1

  公开（公告）日：2020-04-14

  A method of reducing an aromatic ring under relatively mild condition using sub-nano particles of a transition metal supported on super paramagnetic iron oxide nanoparticles (SPIONs). The catalyst is efficient for catalyzing the reduction of both carbocyclic and heterocyclic compound. In compound comprising both carbocyclic and heterocyclic aromatic rings, the catalyst displays high regioselectivity for the heterocyclic ring.

  使用支持在超顺磁铁氧化物纳米颗粒（SPIONs）上的过渡金属次纳米颗粒，在相对温和的条件下还原芳香环的方法。该催化剂对于催化碳环和杂环化合物的还原效率高。在包含碳环和杂环芳香环的化合物中，催化剂对于杂环环具有高的区域选择性。
• sGC STIMULATORS
  申请人：Ironwood Pharmaceuticals, Inc.

  公开号：US20180065971A1

  公开（公告）日：2018-03-08

  The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable. The compounds are of Formula I:

  本公开涉及可溶性鸟苷酸环化酶（sGC）的激动剂，包括它们的药物配方及其单独或与一个或多个额外药剂联合使用以治疗各种疾病，其中氮氧化物（NO）浓度增加、环鸟苷酸单磷酸（cGMP）浓度增加、或两者增加，或NO途径上调是可取的。这些化合物属于式I：
• PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US20130158044A1

  公开（公告）日：2013-06-20

  The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.

  本发明提供了一种由通式（1）表示的杂环化合物：该化合物对包括中枢神经系统疾病在内的精神障碍具有广泛的治疗谱，没有副作用且安全性高。
• Processes
  申请人：ZENECA LIMITED

  公开号：EP0434316A1

  公开（公告）日：1991-06-26

  A process for addition polymerisation of vinylic (in particuar methacrylic) monomers at a temperature in the range of -20 to 60°C, in the presence of a catalyst comprising: (a) a first component of empirical formula (I): wherein M is an alkali metal atom; and T is bulky hydrocarbyl which contains at least 4 carbon atoms and is optionally substituted by one or more pendent substituents, or hetero-substituted hydrocarbyl, each of which is inert in the process conditions; and (b) a (co-catalyst) second component comprising a compound of empirical formula (II): wherein Q is Al, B or Zn; m, n and p are each 0 or an integer such that (m + n + p) = 2 or 3 (depending on the appropriate valency of Q; and X, Y and Z are each independently optionally substituted bulky hydrocarbyl, or X and Y together are optionally substituted hydrocarbadiyl, and Z is optionally substituted bulky hydrocarbyl, all of which groups are inert in the process conditions.

  在催化剂存在下，乙烯基（特别是甲基丙烯酸）单体在-20-60℃温度范围内进行加成聚合的工艺，包括 (a) 经验式 (I) 的第一组分： 其中 M 是碱金属原子；和 T 是含有至少 4 个碳原子且任选被一个或多个下垂取代基取代的笨重烃基，或杂取代烃基，其中每个取代基在工艺条件下都是惰性的；以及 (b) 由经验式（II）化合物组成的（助催化剂）第二组分： 其中 Q 是 Al、B 或 Zn m、n 和 p 各为 0 或整数，使得 (m + n + p) = 2 或 3（取决于 Q 的适当价数；以及 X、Y 和 Z 各自独立地是任选取代的笨重烃基，或 X 和 Y 共同为任选取代的烃基，Z 为任选取代的笨重烃基、 所有这些基团在加工条件下均为惰性。
• Water-developable photosensitive composition and production process thereof
  申请人：Nippon Paint Co., Ltd.

  公开号：EP0859284A1

  公开（公告）日：1998-08-19

  The present invention provides a water-developable photosensitive composition capable of providing a flexographic printing plate with a satisfactory shelf life, excellent water developability, water resistance, ink resistance and aging resistance, as well as an adequate impact resilience necessary for a high evenness of the reproduced image, and a production process thereof. A water-developable photosensitive composition comprising (A) a thermoplastic elastic polymer, (B) an ionic group- and photopolymerizable double bond-containing hydrophilic polymer, (C) a crosslinking particulate resin having an ionic group capable of forming an ion pair with said polymer (B), and (D) a photopolymerization initiator.

  本发明提供了一种可用水显影的感光组合物，该组合物能够提供具有令人满意的保质期、优异的水显影性、耐水性、耐油墨性和耐老化性，以及再现图像的高均匀性所需的足够的冲击回弹力的柔性版印刷板，并提供了其生产工艺。 一种水显影感光组合物，包括 (A) 热塑性弹性聚合物，(B) 含离子基团和可光聚合双键的亲水性聚合物，(C) 具有能与所述聚合物 (B) 形成离子对的离子基团的交联微粒树脂，以及 (D) 光聚合引发剂。