pyridinylpyrimidine | 10198-83-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: pyridinylpyrimidine
• 英文别名: 2-(pyridin-2-yl)pyrimidine；2-(2-pyridyl)pyrimidine；pyridylpyrimidine；2-pyridin-2-ylpyrimidine
• CAS: 10198-83-1
• 化学式: C₉H₇N₃
• 分子量: 157.175
• InChiKey: YJVKLLJCUMQBHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  pyridinylpyrimidine 、 dichlorotetrakis(dimethylsulfoxide)ruthenium 在 水 作用下， 以 乙醇 为溶剂， 以32%的产率得到{Ru(2-(2-pyridyl)pyrimidine)3}Cl2*5H2O
  参考文献：
  名称：

  Kawanishi, Yuji; Kitamura, Noboru; Tazuke, Shigeo, Inorganic Chemistry, 1989, vol. 28, # 15, p. 2968 - 2975

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(2-pyrimidinyl)-1,2,4-triazine 、 乙烯基癸酸 以88.7%的产率得到pyridinylpyrimidine
  参考文献：
  名称：

  Synthesis of 2-Pyridylpyridines via Aza-Diels–Alder Reactions between 3-Pyridyl-1,2,4-triazines and Some Vinyl Alkanoates

  摘要：

  描述了一种新的合成2,ω-联吡啶的方法，涉及3-(ω-吡啶基)-1,2,4-三嗪与乙烯基辛酸酯或癸酸酯（作为二烯亲二体）之间的氮杂-狄尔斯-阿尔德反应。

  DOI：

  10.1246/cl.2005.836

文献信息

• SUBSTITUTED PYRIDINYL-PYRIMIDINES AND THEIR USE AS MEDICAMENTS
  申请人：Dahmann Georg

  公开号：US20130023502A1

  公开（公告）日：2013-01-24

  The invention relates to new substituted pyridinyl-pyrimidines of formula 1 wherein ring A is a five-membered saturated or unsaturated carbocyclic ring which optionally comprises one, two or three heteroatoms each independently from each other selected from the group N, S and O, wherein R 1 , R 2 , R 4 , R 3 , R 5 and R 6 are defined as in claim 1 and wherein ring A is further optionally substituted by one or two further substituents and the pharmaceutically acceptable salts, diastereomers, enantiomers, racemates, hydrates and solvates of the aforementioned compounds.

  该发明涉及公式1中的新取代吡啶基嘧啶化合物， 其中环A是一个含有五个成员的饱和或不饱和碳环，该环可选地包含一个、两个或三个异原子，每个异原子独立地选自N、S和O组成， 其中R1、R2、R4、R3、R5和R6如权利要求书中所定义，并且环A进一步可选地被一个或两个进一步取代基取代，以及上述化合物的药用盐、二对映体、对映体、消旋体、水合物和溶剂化合物。
• PROCESS FOR PREPARING A PROPIOLIC ACID OR A DERIVATIVE THEREOF
  申请人：Goossen Lukas J

  公开号：US20140012000A1

  公开（公告）日：2014-01-09

  The invention relates to a process for preparing a propiolic acid or a derivative thereof by reacting a terminal alkyne with carbon dioxide, which comprises performing the reaction in the presence of a base and a copper complex, especially a copper (I) complex having at least one ligand, at least one of the ligands of the copper complex being selected from monodentate ligands which have an aminic or iminic nitrogen atom capable of coordination with copper, and polydentate ligands having at least two atoms or atom groups which are capable of simultaneous coordination with copper and are selected from nitrogen, oxygen, sulfur, phosphorus and carbene carbon.

  该发明涉及一种通过将末端炔烃与二氧化碳反应制备丙炔酸或其衍生物的方法，其中在碱和铜络合物的存在下进行反应，特别是在至少具有一个配体的铜（I）络合物的存在下进行反应，铜络合物的配体中至少有一个被选择自具有能够与铜配位的氨基或亚胺基氮原子的一价配体，以及具有至少两个能够与铜同时配位的原子或原子团的多齿配体，这些原子或原子团被选择自氮、氧、硫、磷和卡宾碳。
• Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof
  申请人：Cytovia, Inc.

  公开号：US20030069239A1

  公开（公告）日：2003-04-10

  The present invention is directed to substituted 2-aryl-4-arylaminopyrimidine and analogs thereof, represented by the general Formula I: 1 wherein A, Ar 1 , Ar 2 , R 1 and R 3 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

  本发明涉及被一般式I所代表的取代的2-芳基-4-芳基氨基嘧啶及其类似物： 其中A，Ar1，Ar2，R1和R3在此处被定义。本发明还涉及发现具有式I的化合物是caspase的激活剂和凋亡诱导剂。本发明的化合物可用于诱导在出现未受控制的异常细胞生长和扩散的各种临床病况中的细胞死亡。
• PHENYLTHIAZOLES AND USES THEREOF
  申请人：Purdue Research Foundation

  公开号：US20180319784A1

  公开（公告）日：2018-11-08

  Series of 2-phenyl-4-methylthiazole analogues are disclosed as potential therapeutic agents for the treatment of bacterial infections, especially methicillin-resistant Straphylococcus aureus (MRSA) related infections. A method for the treatment of MRSA-related infections is also claimed.

  一系列2-苯基-4-甲基噻唑类似物被披露为治疗细菌感染，特别是耐甲氧西林金黄色葡萄球菌（MRSA）相关感染的潜在治疗药物。还声明了一种治疗MRSA相关感染的方法。
• Palladium(0)-Catalyzed, Copper(I)-Mediated Coupling of Cyclic Thioamides with Alkenylboronic Acids, Organostannanes, and Siloxanes
  作者：Nuzhat Arshad、Jamshed Hashim、C. Oliver Kappe

  DOI：10.1021/jo900848s

  日期：2009.7.17

  The Pd-catalyzed cross-coupling of cyclic thioamides and thioureas with alkenylboronic acids, vinyl- and (het)arylstannanes, and arylsiloxanes in the presence of stoichiometric amounts of a Cu(I) cofactor is described. The desulfitative C−C cross-coupling protocol of the Liebeskind−Srogl type is performed under neutral conditions and can be applied to a range of heterocyclic structures with embedded

  描述了在化学计量的Cu（I）辅因子存在下，Pd催化的环硫酰胺和硫脲与烯基硼酸，乙烯基和（杂）芳基锡烷以及芳基硅氧烷的交叉偶联。Liebeskind-Srogl类型的脱硫C-C交叉偶联方案是在中性条件下进行的，可应用于具有嵌入的硫酰胺片段的杂环结构。通过使用单模反应器或多模并联反应平台在100°C下进行受控的微波辐射，交叉偶联通常可在1-3 h内完成，并以良好的收率进行。