1-(sec-butoxy)-4-(trifluoromethyl)benzene | 1330533-74-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(sec-butoxy)-4-(trifluoromethyl)benzene
• 英文别名: 1-Butan-2-yloxy-4-(trifluoromethyl)benzene；1-butan-2-yloxy-4-(trifluoromethyl)benzene
• CAS: 1330533-74-8
• 化学式: C₁₁H₁₃F₃O
• 分子量: 218.219
• InChiKey: MVGGOHGWFNUNSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  [4-(三氟甲基)苯基](2,4,6-三甲基苯基)碘鎓三氟甲磺酸盐 在 sodium hydride 、 potassium bromide 作用下， 以 二氯甲烷 、 甲基叔丁基醚 、 水 、 mineral oil 为溶剂， 反应 1.75h， 生成 1-(sec-butoxy)-4-(trifluoromethyl)benzene
  参考文献：
  名称：

  Base Mediated Synthesis of Alkyl-aryl Ethers from the Reaction of Aliphatic Alcohols and Unsymmetric Diaryliodonium Salts

  摘要：

  The base mediated coupling of aliphatic alcohol pronudeophiles with unsymmetric diaryliodonium salt electrophiles is described. This metal-free reaction is operationally simple, proceeds at mild temperature, and displays broad substrate scope to generate industrially important alkyl-aryl ethers in moderate to excellent yield. The synthetic utility of these reactions is demonstrated, and aspects of sustainability are highlighted by the use of unsymmetric aryl(mesityl)iodonium arylating reagents.

  DOI：

  10.1021/acs.joc.5b00907

文献信息

• An Efficient Copper-Catalyzed Etherification of Aryl Halides
  作者：Jinkun Huang、Ying Chen、Johann Chan、Mike Ronk、Robert Larsen、Margaret Faul

  DOI：10.1055/s-0030-1260761

  日期：2011.6

  An efficient and mild copper-catalyzed ether formation from aryl halides and aliphatic alcohols has been developed. The key to the successful coupling is the use of lithium alkoxide, directly or in situ generated by lithium tert-butoxide, and the corresponding alcohol as solvent.

  已经开发出一种由芳基卤化物和脂肪醇形成的有效且温和的铜催化醚形成。成功偶联的关键是使用由叔丁醇锂直接或原位生成的醇锂，以及相应的醇作为溶剂。
• COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY
  申请人：IFM Due, Inc.

  公开号：US20220024906A1

  公开（公告）日：2022-01-27

  This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

  本公开涉及化学实体（例如，化合物或药用盐，和/或水合物，和/或共晶体，和/或该化合物的药物组合），其抑制（例如，拮抗）干扰素基因激活器（STING）。所述化学实体可用于治疗病症、疾病或疾病，其中增加（例如，过量）STING激活（例如，STING信号传导）导致病理和/或症状和/或病症的进展（例如，癌症）在受试者（例如，人类）中。本公开还涉及含有相同化学实体的组合物，以及使用和制备该组合物的方法。
• Novel Bicyclic Pyridinones
  申请人：Pfizer Inc.

  公开号：US20140045790A1

  公开（公告）日：2014-02-13

  Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

  本文披露了化合物及其医药上可接受的盐，其中所述化合物具有如下所定义的I式结构。同时还披露了相应的药物组合物、治疗方法、合成方法和中间体。
• Base Mediated Synthesis of Alkyl-aryl Ethers from the Reaction of Aliphatic Alcohols and Unsymmetric Diaryliodonium Salts
  作者：Sunil K. Sundalam、David R. Stuart

  DOI：10.1021/acs.joc.5b00907

  日期：2015.6.19

  The base mediated coupling of aliphatic alcohol pronudeophiles with unsymmetric diaryliodonium salt electrophiles is described. This metal-free reaction is operationally simple, proceeds at mild temperature, and displays broad substrate scope to generate industrially important alkyl-aryl ethers in moderate to excellent yield. The synthetic utility of these reactions is demonstrated, and aspects of sustainability are highlighted by the use of unsymmetric aryl(mesityl)iodonium arylating reagents.