6-Amino-trans-hexen-(2)-saeure | 145119-04-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-Amino-trans-hexen-(2)-saeure
• 英文别名: 6-amino-2(E)-hexenoic acid；6-aminohex-2-enoic acid；(E)-6-amino-hex-2-enoic acid；(E)-6-aminohex-2-enoic acid
• CAS: 145119-04-6
• 化学式: C₆H₁₁NO₂
• 分子量: 129.159
• InChiKey: SNACICYKKILLEK-DUXPYHPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-Phthalimido-hexen-(2)-saeure 在 sodium hydroxide 作用下， 生成 6-Amino-trans-hexen-(2)-saeure
  参考文献：
  名称：

  Synthesis of racemic threo- and erythro-.beta.-hydroxylysines

  摘要：

  DOI：

  10.1021/jo01260a014

文献信息

• [EN] PROCESSES FOR PRODUCING AMINE COMPOUNDS<br/>[FR] PROCÉDÉ DE PRODUCTION DE COMPOSÉS AMINE
  申请人：UNIV MONASH

  公开号：WO2014005196A1

  公开（公告）日：2014-01-09

  The present invention provides processes for producing amine-containing compounds such as diammonium salts and amino acid derivatives comprising the steps of subjecting a salt of an amine bearing an unsaturated group to a self-metathesis reaction with itself to produce a diammonium salt or to a cross-metathesis with a suitable α,β-unsaturated acid, ester or amide to form an amino acid salt or a derivative thereof. The salts produced by the metathesis reactions can then be subjected to hydrogenation to reduce the double bond which is formed in the metathesis reaction.

  本发明提供了生产胺含化合物的工艺，例如二铵盐和氨基酸衍生物的步骤，包括将带有不饱和基团的胺盐置于自我交换反应中，以产生二铵盐，或与适当的α，β-不饱和酸、酯或酰胺进行交叉交换反应，形成氨基酸盐或其衍生物。然后可以将通过交换反应产生的盐进行加氢，以减少在交换反应中形成的双键。
• UNSATURATED FATTY AMINO ACID DERIVATIVES AND USE THEREOF IN DERMAL COSMETOLOGY
  申请人：Tarroux Roger

  公开号：US20100240754A1

  公开（公告）日：2010-09-23

  The present invention relates to drugs consisting of unsaturated fatty amino-acid derivatives of the general formula (I), and to their pharmaceutically acceptable acid addition salts, in which: X is oxygen or NH, Rn are independently hydrogen or a (C 1 -C 6 )alkyl optionally substituted by halogen; R 1 is hydrogen, fluorine, chlorine or bromine, or a CF 3 or CHF 2 or a (C 1 -C 6 )alkyl, (C 1 -C 6 )alkenyl or (C 1 -C 6 )alkynyl, optionally substituted by one or more halogen atoms; R is hydrogen or a (C 1 -C 6 )alkyl or (C 3 -C 6 )cycloalkyl optionally substituted by one or more halogen atoms; Ra and Rb are independently hydrogen (C 1 -C 6 )alkyl or (C 1 -C 6 )acyl, and Ra and Rb a hydrocarbonated cycle containing 4 to 6 carbon atoms; and n is an integer between 2 and 14.

  本发明涉及一种由通式（I）的不饱和脂肪氨基酸衍生物组成的药物，以及它们的药用可接受的酸盐，其中：X为氧或NH，Rn独立地为氢或经卤素取代的（C1-C6）烷基；R1为氢、氟、氯或溴，或者为CF3或CHF2或（C1-C6）烷基、（C1-C6）烯基或（C1-C6）炔基，可以经过一个或多个卤素原子的取代；R为氢或者经过一个或多个卤素原子取代的（C1-C6）烷基或（C3-C6）环烷基；Ra和Rb独立地为氢、（C1-C6）烷基或（C1-C6）酰基，而Ra和Rb为含有4到6个碳原子的碳氢化合物环；n为介于2和14之间的整数。
• Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes
  申请人：3-Dimensional Pharmaceuticals, Inc.

  公开号：US20030105111A1

  公开（公告）日：2003-06-05

  The present invention is directed to a compound of Formula I: 1 wherein A, R 1 , and R 2 are defined herein. The present invention is also directed to compositions comprising compounds of Formula I, methods of using compounds of Formula I, and methods of making compounds of Formula I.

  本发明涉及一种具有以下结构的化合物：其中A、R1和R2在此处被定义。本发明还涉及包含Formula I化合物的组合物、使用Formula I化合物的方法以及制备Formula I化合物的方法。
• [EN] IMPROVED PROCESS FOR THE PREPARATION OF 6-AMINOHEXANOIC ACID<br/>[FR] PROCÉDÉ AMÉLIORÉ POUR LA PRÉPARATION DE L'ACIDE 6-AMINOHEXANOÏQUE
  申请人：MSN LABORATORIES PRIVATE LTD R&D CENTER

  公开号：WO2020031201A1

  公开（公告）日：2020-02-13

  The present invention relates to highly pure 6-aminohexanoic acid of formula-1 which is free of organic volatile impurities, caprolactam impurity and improved process for its preparation thereof. The present invention also relates to an improved process for the preparation of caprolactam of formula-2 which is used for the preparation of 6-aminohexanoic acid of formula-1.

  本发明涉及公式-1的高纯6-氨基己酸，其不含有机挥发性杂质、己内酰胺杂质，并提供其制备的改进方法。本发明还涉及一种改进的公式-2己内酰胺的制备方法，该方法用于制备公式-1的6-氨基己酸。
• [EN] THE PREPARATION OF CAPROLACTAM FROM 6-AMINO CAPROIC ACID OBTAINED IN A FERMENTATION PROCESS<br/>[FR] PRÉPARATION DE CAPROLACTAME À PARTIR D'ACIDE 6-AMINOCAPROÏQUE OBTENU DANS UN PROCÉDÉ DE FERMENTATION
  申请人：DSM IP ASSETS BV

  公开号：WO2011078668A1

  公开（公告）日：2011-06-30

  The invention relates to a method for preparing caprolactam comprising recovering a mixture containing 6-aminocaproic acid, from a culture medium comprising biomass, and thereafter cyclising the 6-aminocaproic acid in the presence of superheated steam, thereby forming caprolactam, wherein the weight to weight ratio carbohydrate to 6-aminocaproic acid in said mixture is 0.03 or less.

  本发明涉及一种制备己内酰胺的方法，包括从含有生物量的培养基中回收含有6-氨基己酸的混合物，然后在超热蒸汽的存在下使6-氨基己酸环化，从而形成己内酰胺，其中所述混合物中碳水化合物与6-氨基己酸的重量比为0.03或更低。