phenyl (5-methylisoxazol-4-yl)carbamate | 1190843-60-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenyl (5-methylisoxazol-4-yl)carbamate
• 英文别名: Phenyl (5-methylisoxazol-4-yl)carbamate；phenyl N-(5-methyl-1,2-oxazol-4-yl)carbamate
• CAS: 1190843-60-7
• 化学式: C₁₁H₁₀N₂O₃
• 分子量: 218.212
• InChiKey: PRRIVDCWLGENRG-UHFFFAOYSA-N

物化性质

• 沸点：
  338.3±34.0 °C(Predicted)
• 密度：
  1.309±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-甲基-4-异噁唑胺 、 氯甲酸苯酯 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 以64%的产率得到phenyl (5-methylisoxazol-4-yl)carbamate
  参考文献：
  名称：

  [EN] ETHER BENZYLIDENE PIPERIDINE 5-MEMBERED ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS
  [FR] COMPOSÉS D'ÉTHER-BENZYLIDÈNE-PIPÉRIDINE-ARYL À 5 CHAÎNONS-CARBOXAMIDE UTILES COMME INHIBITEURS DE FAAH

  摘要：

  本发明涉及式(I)的化合物，及其在治疗FAAH介导的疾病或症状中的应用的药用盐。

  公开号：

  WO2009127943A1

文献信息

• ETHER BENZYLIDENE PIPERIDINE ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS
  申请人：Fay Lorraine Kathleen

  公开号：US20110144159A1

  公开（公告）日：2011-06-16

  The present invention relates to compounds of Formula (I) wherein Ar is optionally substituted phenyl or 6-membered heteroaryl moiety, or a benzisoxazole, pyrrolopyridine, or benzotriazole group; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity, including pain, urinary incontinence, overactive bladder, emesis, cognitive disorders, anxiety, depression, sleeping disorders, eating disorders, movement disorders, glaucoma, psoriasis, multiple sclerosis, cerebrovascular disorders, brain injury, gastrointestinal disorders, hypertension, or cardiovascular disease.

  本发明涉及式(I)的化合物，其中Ar是可选的取代苯基或6元杂环基团，或苯并异噁唑、吡咯吡啶或苯并三氮唑基团；或其药学上可接受的盐；制备该化合物的过程；制备该化合物的中间体；含有该化合物的组合物；以及在治疗与脂肪酸酰胺水解酶（FAAH）活性相关的疾病或病症中使用该化合物，包括疼痛、尿失禁、过度活动的膀胱、呕吐、认知障碍、焦虑、抑郁、睡眠障碍、进食障碍、运动障碍、青光眼、牛皮癣、多发性硬化症、脑血管疾病、脑损伤、胃肠疾病、高血压或心血管疾病。
• ETHER BENZYLIDENE PIPERIDINE 5-MEMBERED ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS
  申请人：Fay Lorraine Kathleen

  公开号：US20110053982A1

  公开（公告）日：2011-03-03

  The present invention relates to compounds of the Formula (I), and pharmaceutically acceptable salts thereof, and their use in the treatment of FAAH-mediated diseases or condition.

  本发明涉及式（I）的化合物及其药学上可接受的盐，以及它们在治疗FAAH介导的疾病或病况方面的用途。
• 4-[3-(ARYLOXY)BENZYLIDENE]-3-METHYL PIPERIDINE 5-MEMBERED ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS
  申请人：Meyers Marvin Jay

  公开号：US20110060012A1

  公开（公告）日：2011-03-10

  The present invention relates to compounds of Formula (I), wherein Ar is a 5-membered heteroaryl moiety and X, Y and Z are independently N or CH; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity.

  本发明涉及公式（I）的化合物，其中Ar是5-成员杂环芳基基团，X，Y和Z分别是N或CH；或其药学上可接受的盐；制备该化合物的方法；用于制备该化合物的中间体；含有该化合物的组合物；以及用于治疗与脂肪酸酰胺水解酶（FAAH）活性相关的疾病或病况的化合物的用途。
• 4-[3-(ARYLOXY)BENZYLIDENE]-3-METHYL PIPERIDINE ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS
  申请人：Meyers Marvin Jay

  公开号：US20110053949A1

  公开（公告）日：2011-03-03

  The present invention relates to compounds of Formula (I), wherein Ar is optionally substituted phenyl or heteroaryl and X, Y and Z are independently N or CH; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity.

  本发明涉及式（I）的化合物，其中Ar是可选取代的苯基或杂环芳基，X、Y和Z分别是N或CH；或其药学上可接受的盐；制备该化合物的方法；制备该化合物所用的中间体；含有该化合物的组合物；以及使用该化合物治疗与脂肪酸酰胺水解酶（FAAH）活性相关的疾病或症状。
• [EN] ETHER BENZYLIDENE PIPERIDINE ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS<br/>[FR] COMPOSÉS D'ÉTHER-BENZYLIDÈNE-PIPÉRIDINE-ARYL-CARBOXAMIDE UTILES COMME INHIBITEURS DE FAAH
  申请人：PFIZER

  公开号：WO2009127944A8

  公开（公告）日：2010-12-09