N,N-diethyl-3-methyl-4-pentenamide | 308141-65-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N-diethyl-3-methyl-4-pentenamide
• 英文别名: N,N-diethyl-3-methylpent-4-enamide
• CAS: 308141-65-3
• 化学式: C₁₀H₁₉NO
• 分子量: 169.267
• InChiKey: GOQPDQXAOYGDLV-UHFFFAOYSA-N

物化性质

• 沸点：
  237.5±19.0 °C(Predicted)
• 密度：
  0.874±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N-diethyl-3-methyl-4-pentenamide 在 碘 作用下， 以 水 、 乙腈 为溶剂， 反应 18.0h， 生成 trans-γ-iodomethyl-β-methyl-γ-butyrolactone 、 cis-γ-iodomethyl-β-methyl-γ-butyrolactone
  参考文献：
  名称：

  Stereocontrolled Iodolactonization of Acyclic Olefinic Amides

  摘要：

  Acyclic olefinic amides were iodolactonized in the mixed solvent of CH3CN and H2O (90:10, v/v) under reflux to give products with trans configuration of the newly formed iodomethyl to the inherent alkyl group in high yield.

  DOI：

  10.1080/00397910008086991
• 作为产物：
  描述：

  1-But-3-en-2-yloxyethenol 生成 N,N-diethyl-3-methyl-4-pentenamide
  参考文献：
  名称：

  Stereocontrolled Iodolactonization of Acyclic Olefinic Amides

  摘要：

  Acyclic olefinic amides were iodolactonized in the mixed solvent of CH3CN and H2O (90:10, v/v) under reflux to give products with trans configuration of the newly formed iodomethyl to the inherent alkyl group in high yield.

  DOI：

  10.1080/00397910008086991

文献信息

• Triethylborane-Induced Radical Allylation Reaction with Zirconocene−Olefin Complex
  作者：Koji Hirano、Kazuya Fujita、Hiroshi Shinokubo、Koichiro Oshima

  DOI：10.1021/ol036431e

  日期：2004.2.1

  [reaction: see text] Allylzirconium reagents are effective for radical allylation of alpha-halo carbonyl compounds. The key steps would be homolytic cleavage of the zirconium-carbon bond and halogen abstraction by the resulting Cp(2)ZrCl(III). Zirconocene-olefin complex can be also utilized for the allylation of alpha-halo compounds.

  [反应：见正文]烯丙基锆试剂可有效地使α-卤代羰基化合物自由基烯丙基化。关键步骤将是锆-碳键的均质裂解和所得Cp（2）ZrCl（III）的卤素抽象。锆茂-烯烃配合物也可用于α-卤代化合物的烯丙基化。
• Stereocontrolled Iodolactonization of Acyclic Olefinic Amides
  作者：Hyun-Joon Ha、Sang-Youn Lee、Young-Soo Park

  DOI：10.1080/00397910008086991

  日期：2000.10

  Acyclic olefinic amides were iodolactonized in the mixed solvent of CH3CN and H2O (90:10, v/v) under reflux to give products with trans configuration of the newly formed iodomethyl to the inherent alkyl group in high yield.