N-phenyl-N'-(2-hydroxylphenyl)urea | 13142-79-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenyl-N'-(2-hydroxylphenyl)urea
• 英文别名: N-(2-hydroxy-phenyl)-N'-phenyl-urea；N-(2-Hydroxy-phenyl)-N'-phenyl-harnstoff；1-(2-Hydroxyphenyl)-3-phenylurea
• CAS: 13142-79-5
• 化学式: C₁₃H₁₂N₂O₂
• 分子量: 228.25
• InChiKey: SOTPAHSLPCKYOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.4
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-phenyl-N'-(2-hydroxylphenyl)urea 在 alkaline solution 作用下， 生成 2-苯并唑啉酮
  参考文献：
  名称：

  EFFICACY, SAFETY AND PATIENT SATISFACTION OUTCOMES OF THE AMS 700CX INFLATABLE PENILE PROSTHESIS: RESULTS OF A LONG-TERM MULTICENTER STUDY

  摘要：

  Purpose: We performed a long-term multicenter study of the AMS 700CX double dagger 3-piece inflatable penile prosthesis, focusing on longevity, morbidity and patient satisfaction in men implanted up to 134 months with a median followup of 47.7 months.Materials and Methods: We performed a large scale retrospective multicenter study in 2 phases. Phase 1 was a medical record review of 372 men who underwent implantation with the AMS 700CX penile prosthesis from 1987 to 1996 by 7 frequent penile prosthesis implanters, Phase 2 included a structured telephone interview of 207 patients by a neutral observer.Results: For the 372 men in phase 1 mean device mechanical reliability plus or minus standard deviation was 92.1% +/- 3.3% affer 3 and 86.2% +/- 4.6% after 5 years. Patient age was 21 to 79 years (mean 57.6 +/- 11.0) at implantation. The etiology of erectile dysfunction was vascular in 27.7% of the cases, Peyronie's disease in 16.9%, diabetes mellitus in 12.9% and radical surgery in 11.6%. Of the men 55.6% received previous treatment for erectile dysfunction. Postoperative infection and device malfunction developed in 3.2% and 17.5% of the cases, respectively. Of the 207 men interviewed in phase 2, 86% still had an AMS 700CX penile prosthesis implanted, including 87.1% with erection suitable for coitus. Currently 79% of those with a device use it at least twice monthly and 88.2% would recommend an implant to a relative or friend.Conclusions: The AMS 700CX penile implant produced suitable erection and excellent patient satisfaction at long-term followup in the majority of men. Implant reliability is excellent and postoperative morbidity is low.

  DOI：

  10.1016/s0022-5347(05)67364-8
• 作为产物：
  描述：

  1-苯基-3-(2-甲氧基苯基)脲 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以95%的产率得到N-phenyl-N'-(2-hydroxylphenyl)urea
  参考文献：
  名称：

  超结构卟啉衍生物的合成和研究 - CcO 模拟模型的潜在构建块

  摘要：

  合成了一种新型卟啉复合物，该复合物含有与三齿配体连接的 Fe 卟啉，其中可以配位 Cu 离子。该分子还掺入了通过尿素键连接到卟啉环上的酪氨酸模拟物，并被充分表征。我们用旋转环盘电极电化学研究了分子氧对几种卟啉衍生物的作用。 (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

  DOI：

  10.1002/ejoc.200801122

文献信息

• 一种脲类化合物的合成方法及应用
  申请人：浙江大学

  公开号：CN109776244A

  公开（公告）日：2019-05-21

  本发明一种脲类化合物的合成方法，通过将取代噁唑酮，乙酸钠，加入到甲醇溶液中，搅拌条件下加入取代胺，反应2‑15h，通过柱层析得到脲类化合物。本发明克服了现有合成过程中需要用到具有危险性的化合物的缺点，采用一锅法代替了现有产率低的反应。本方法的反应条件温和，操作简单，原料容易得到，底物可转化为多种其他有用的分子，具有很强的实用性。可应用到农药杀草隆、利尿隆和抗癌药物索拉非尼的合成，本发明是一种工艺简单、成本低、绿色环保的不对称脲类化合物的合成方法。
• RECORDING MATERIAL AND COMPOUND
  申请人：Nippon Soda Co., Ltd.

  公开号：EP3636446A1

  公开（公告）日：2020-04-15

  An object of the present invention is to provide a recording material or a recording sheet using, as a color-developing agent, a non-phenol-based compound good in color developing performance and the like. A compound represented by the following formula (I) is used as the color-developing agent: (wherein X represents CH2 or the like; R1 to R3 each independently represent a hydrogen atom, a halogen atom or the like; n1 and n3 each independently represent any integer of 1 to 5; two groups represented by R3 adjacent to each other on a benzene ring optionally bond to each other to form an optionally substituted 6-membered ring; and n2 represents any integer of 1 to 4).

  本发明的目的是提供一种记录材料或记录薄片，使用显色性能良好的非酚基化合物作为显色剂等。下式 (I) 所代表的化合物被用作显色剂： (其中 X 代表 CH2 或类似物；R1 至 R3 各自独立地代表氢原子、卤素原子或类似物；n1 和 n3 各自独立地代表 1 至 5 的任意整数；R3 所代表的两个基团在苯环上相邻，可选择彼此结合形成任选取代的 6 元环；以及 n2 代表 1 至 4 的任意整数）。
• Heat-sensitive recording material
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：US10780724B2

  公开（公告）日：2020-09-22

  To provide a heat-sensitive recording material which produces images with excellent resistance to water, while producing background with resistance to heat. A heat-sensitive recording material which is characterized by containing at least one compound represented by general formula (1) as a color-developing compound: wherein, R1-R5 each independently represents a hydrogen atom, a halogen atom, a nitro group, an amino group, an alkyl group, an alkoxy group, an aryloxy group, an alkylcarbonyloxy group, an arylcarbonyloxy group, an alkylcarbonylamino group, an arylcarbonylamino group, an alkylsulfonylamino group, an arylsulfonylamino group, a monoalkylamino group, a dialkylamino group or an arylamino group.

  提供一种热敏记录材料，它能产生耐水性极佳的图像，同时产生耐热背景。一种热敏记录材料，其特征在于含有至少一种通式（1）代表的化合物作为显色化合物： 其中，R1-R5 各自独立地代表氢原子、卤素原子、硝基、氨基、烷基、烷氧基、芳氧基、烷基羰氧基、芳基羰氧基、烷基羰基氨基、芳基羰基氨基、烷基磺酰基氨基、芳基磺酰基氨基、单烷基氨基、二烷基氨基或芳基氨基。
• Recording material and compound
  申请人：NIPPON SODA CO., LTD.

  公开号：US11529819B2

  公开（公告）日：2022-12-20

  An object of the present invention is to provide a recording material or a recording sheet using, as a color-developing agent, a non-phenol-based compound good in color developing performance and the like. A compound represented by the following formula (I) is used as the color-developing agent: (wherein X represents CH 2 or the like; R 1 to R 3 each independently represent a hydrogen atom, a halogen atom or the like; n1 and n3 each independently represent any integer of 1 to 5; two groups represented by R 3 adjacent to each other on a benzene ring optionally bond to each other to form an optionally substituted 6-membered ring; and n2 represents any integer of 1 to 4).

  本发明的目的是提供一种记录材料或记录薄片，使用显色性能良好的非酚基化合物等作为显色剂。由下式（I）代表的化合物被用作显色剂：（其中 X 代表 CH 2 或类似物；R 1 至 R 3 各自独立地代表氢原子、卤素原子或类似物；n1 和 n3 各自独立地代表 1 至 5 的任意整数；在苯环上相邻的两个由 R 3 代表的基团可任意地相互键合以形成任选取代的 6 元环；以及 n2 代表 1 至 4 的任意整数）。
• Ma, Xiao-bo; Zhang, Jing-lin, Phosphorus, Sulfur and Silicon and the Related Elements, 1990, vol. 53, # 1-4, p. 227 - 231
  作者：Ma, Xiao-bo、Zhang, Jing-lin

  DOI：——

  日期：——