(1-bromoallyl)benzene | 70032-14-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1-bromoallyl)benzene
• 英文别名: 3-phenyl-3-bromo-1-propene；Benzene, (1-bromo-2-propenyl)-；1-bromoprop-2-enylbenzene
• CAS: 70032-14-3
• 化学式: C₉H₉Br
• 分子量: 197.074
• InChiKey: FXLJHFCTYDFUER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (1-bromoallyl)benzene 在 potassium carbonate 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 28.0h， 生成 2-Hydroxymethyl-3-phenyl-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester
  参考文献：
  名称：

  A Novel Synthesis of 2-Hydroxymethyl-3-Phenyl-1, 4-Benzodioxanes

  摘要：

  The reaction of 3,4-dihydroxybenzaldehyde (4a), methyl-(3,4-dihydroxy) benzoate (4b), ethyl-(3,4-dihydroxy) benzoate (4c), 3,4-dihydroxybenzonitrile (4d), 2,3-dihydroxynitrobenzene (4e) with 2-bromomethyl-3-phenyl oxirane (3) in acetone-K2CO3 medium gave six membered heterocycles, 2-hydroxymethyl-3-phenyl-1,4-benzodioxanes (5a-e) regioselectively.

  DOI：

  10.1080/00397919808004893
• 作为产物：
  描述：

  烯丙苯 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氯化碳 为溶剂， 反应 24.0h， 以75%的产率得到(1-bromoallyl)benzene
  参考文献：
  名称：

  铑（iii）通过C（sp 3）–H / C（sp 2）–H键断裂对苯胺和烯丙基苯的区域选择性氧化环化†

  摘要：

  本文描述的是将烯丙基C（sp 3）-H激活和定向C（sp 2）-H激活合并为单一方法以发现前所未有的化学转化。作为概念验证，我们首次公开了铑催化的苯胺与烯丙基苯的区域选择性氧化环合反应，以释放出各种吲哚。在这项工作中，将烯丙基链段的C3和C2位置分别设置为构建C–N和C–C键。

  DOI：

  10.1039/c8cc09099h

文献信息

• Imidazole compounds having an antiinflammatory effect
  申请人：MERCKLE GMBH

  公开号：EP1894925A1

  公开（公告）日：2008-03-05

  The invention relates to 2-sulfinyl- or 2-sulfonyl-substituted imidazole derivatives of the formula I in which the radicals R1, R2, R3 and R4 have the meaning indicated in the description. The compounds of the invention have an immunomodulating and/or cytokine release-inhibiting effect and are therefore suitable for the treatment of disorders associated with an impairment of the immune system.

  这项发明涉及公式I的2-磺酰基或2-磺酰基取代的咪唑衍生物， 其中基团R1、R2、R3和R4具有描述中指示的含义。该发明的化合物具有免疫调节和/或细胞因子释放抑制作用，因此适用于治疗与免疫系统功能障碍相关的疾病。
• Access to Functionalized Imidazolidin-2-one Derivatives by Iron-Catalyzed Oxyamination of Alkenes
  作者：Anne-Doriane Manick、Sidonie Aubert、Boubacar Yalcouye、Thierry Prangé、Farouk Berhal、Guillaume Prestat

  DOI：10.1002/chem.201802190

  日期：2018.8.6

  Functionalized imidazolidin‐2‐one were prepared by using an iron‐catalyzed alkene oxyamination reaction. Hydroxylamine derivatives were used in this atom‐economical process, and the addition of an external oxidant was not required. The conditions developed were shown to be efficient for mono‐, di‐, and trisubstituted double bonds, and a large scope of diamino alcohol precursors were delivered in good

  功能化的咪唑烷基-2-酮是通过铁催化的烯烃氧胺化反应制备的。在此原子经济过程中使用了羟胺衍生物，不需要添加外部氧化剂。已证明开发的条件对于单，双和三取代的双键是有效的，并且以高收率和良好的非对映选择性提供了大量的二氨基醇前体。已研究了该机理途径，并且似乎涉及融合的氮丙啶和碳阳离子物质。
• Tin Powder-Promoted Cascade Condensation/Allylation/Lactamization: Synthesis of Isoindolinones and Pyrazoloisoindol-8-ones
  作者：Xiaoping Wang、Danfeng Huang、Ke-Hu Wang、Yingpeng Su、Yulai Hu

  DOI：10.1021/acs.joc.9b00733

  日期：2019.6.7

  An efficient tin powder-promoted cascade condensation/allylation/lactamization of 2-formylbenzoic acids, hydrazides, and allyl bromides was developed for the synthesis of isoindolinones in good to excellent yields under mild conditions without any other additives or catalysts. Further manipulation of isoindolinones by iodocyclization process afforded the tricyclic tetrahydro-8H-pyrazolo[5,1-a]isoindol-8-one

  已开发出一种有效的锡粉促进的2-甲酰基苯甲酸，酰肼和烯丙基溴的级联缩合/烯丙基化/内酰胺化反应，可在温和条件下以良好至极佳的收率合成异吲哚啉酮，而无需任何其他添加剂或催化剂。通过碘环化过程进一步操作异吲哚啉酮，得到三环四氢-8 H-吡唑并[5,1- a ] isoindol -8-one衍生物，可以将其转化为更复杂的四环四氢-4 H -azirino [1'，2' ：2,3] pyrazolo [5,1- a ] isoindol-4-ones。
• Tin powder‐promoted oxidation/allylation of glycine esters: Synthesis of <i>γ</i> , <i>δ</i> ‐unsaturated <i>α</i> ‐amino acid esters
  作者：Pengfei Zhao、Danfeng Huang、Feng Wang、Tongyu Han、Ming Yang、Ke‐Hu Wang、Yulai Hu

  DOI：10.1002/aoc.6479

  日期：2022.1

  An efficient tin powder-promoted oxidation/allylation reaction of glycine esters with allyl bromides is developed, which affords γ,δ-unsaturated α-amino acid esters under mild conditions without any other transition metal catalysts. This method avoids the use of unstable imine as starting material, and provides an efficient method for synthesis of γ,δ-unsaturated α-amino acid esters and α-methylene-γ-lactam

  开发了一种有效的锡粉促进甘氨酸酯与烯丙基溴的氧化/烯丙基化反应，该反应在温和条件下提供γ , δ -不饱和α -氨基酸酯，无需任何其他过渡金属催化剂。该方法避免了使用不稳定的亚胺作为起始原料，为合成γ、δ-不饱和α-氨基酸酯和α-亚甲基-γ-内酰胺衍生物提供了一种有效的方法。其他支持信息可在出版商网站上本文的在线版本中找到。
• NOVEL (POLY)AMINE COMPOUND, RESIN AND CURED PRODUCT
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：US20200172470A1

  公开（公告）日：2020-06-04

  A (poly)amine compound represented by the following formula (0): wherein R X is a 2n A -valent group having 1 to 70 carbon atoms or a single bond; each R 1A is independently any of an alkyl group having 1 to 30 carbon atoms and optionally having a substituent, an aryl group having 6 to 30 carbon atoms and optionally having a substituent, a crosslinking group having 2 to 30 carbon atoms and optionally having a substituent, an alkoxy group having 1 to 30 carbon atoms and optionally having a substituent, a halogen atom, a nitro group, an amino group having 0 to 30 carbon atoms and optionally having a substituent, a carboxyl group, a thiol group and a hydroxy group, wherein when R 1A is any of the alkyl group, the aryl group, the crosslinking group and the alkoxy group, R 1A optionally contains at least one bond selected from the group consisting of an ether bond, a ketone bond and an ester bond, and at least one R 1A is an amino group having 0 to 30 carbon atoms and optionally having a substituent; X is an oxygen atom or a sulfur atom, or X is optionally absent; each R independently represents any of a benzene ring, a biphenyl ring, a naphthalene ring, an anthracene ring and a pyrene ring; each m is independently an integer of 0 to 9, wherein at least one m is an integer of 1 to 9; and n A is an integer of 1 to 4.

  由以下公式（0）表示的（聚）胺化合物：其中RX是一个具有1到70个碳原子或单键的2nA价基团；每个R1A独立地是1到30个碳原子的烷基基团，可选地具有取代基，含有6到30个碳原子的芳基基团，可选地具有取代基，含有2到30个碳原子的交联基团，可选地具有取代基，含有1到30个碳原子的烷氧基团，可选地具有取代基，卤原子，硝基基团，含有0到30个碳原子的氨基基团，可选地具有取代基，羧基，硫醇基和羟基，其中当R1A是烷基基团、芳基基团、交联基团和烷氧基团中的任意一种时，R1A可选地含有至少一种从醚键、酮键和酯键组成的键，至少有一个R1A是含有0到30个碳原子且可选地具有取代基的氨基基团；X是氧原子或硫原子，或X可选地不存在；每个R独立地代表苯环、联苯环、萘环、蒽环和芘环中的任意一种；每个m独立地是0到9的整数，至少有一个m是1到9的整数；nA是1到4的整数。