8-Aminooct-4-enoic acid | 55348-89-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 8-Aminooct-4-enoic acid
• 英文别名: (E)-8-aminooct-4-enoic acid
• CAS: 55348-89-5
• 化学式: C₈H₁₅NO₂
• 分子量: 157.21
• InChiKey: VIBUBBGZNCHOEE-OWOJBTEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922499990

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DU VIRUS RESPIRATOIRE SYNCYTIAL
  申请人：CIDARA THERAPEUTICS INC

  公开号：WO2020252396A1

  公开（公告）日：2020-12-17

  Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral RSV F protein (e.g., Presatovir, MDT 637, JNJ 179, or an analog thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., RSV infections).

  用于治疗病毒感染的组合物和方法包括含有病毒RSV F蛋白抑制剂（例如Presatovir、MDT 637、JNJ 179或其类似物）的共轭物，连接到一个Fc单体、一个Fc结构域和Fc结合肽、一种白蛋白蛋白质或白蛋白结合肽。特别是，这些共轭物可以用于治疗病毒感染（例如RSV感染）。
• SEQUENCE SPECIFIC DOUBLE-STRANDED DNA/RNA BINDING COMPOUNDS AND USES THEREOF
  申请人：Rayan Anwar

  公开号：US20130231480A1

  公开（公告）日：2013-09-05

  The present invention provides specific double-stranded DNA/RNA binding compounds having a polymeric structure, which are in fact, triplex forming molecules capable of binding tightly and specifically to predetermined sequences in the major groove of double stranded nucleic acid molecules; as well as pharmaceutical compositions comprising thereof. The triplex forming molecules and the pharmaceutical compositions of the invention can be used for various therapeutic applications such as site-specific modulation of gene expression, targeting of DNA or RNA damage, and gene knockout, as well as for diagnostic applications in vitro.

  本发明提供了具有聚合结构的特定双链DNA / RNA结合化合物，实际上是三链形成分子，能够紧密而特异性地结合到双链核酸分子主沟槽中的预定序列；以及包含它们的制药组合物。本发明的三链形成分子和制药组合物可用于各种治疗应用，例如靶向基因表达的位点特异性调节，靶向DNA或RNA损伤和基因敲除，以及体外诊断应用。
• US4085127A
  申请人：——

  公开号：US4085127A

  公开（公告）日：1978-04-18
• US4218384A
  申请人：——

  公开号：US4218384A

  公开（公告）日：1980-08-19
• [EN] SEQUENCE SPECIFIC DOUBLE-STRANDED DNA/RNA BINDING COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS DE LIAISON À L'ADN/ARN DOUBLE BRIN SPÉCIFIQUES DE CERTAINES SÉQUENCES ET LEURS UTILISATIONS
  申请人：GENEARREST LTD

  公开号：WO2012011114A2

  公开（公告）日：2012-01-26

  The present invention provides specific double-stranded DNA/RNA binding compounds having a polymeric structure, which are in fact, triplex forming molecules capable of binding tightly and specifically to predetermined sequences in the major groove of double stranded nucleic acid molecules; as well as pharmaceutical compositions comprising thereof. The triplex forming molecules and the pharmaceutical compositions of the invention can be used for various therapeutic applications such as site-specific modulation of gene expression, targeting of DNA or RNA damage, and gene knockout, as well as for diagnostic applications in vitro.