N-((S)-10-formyl-5,6,7,8-tetrahydro-pteroyl)-L-glutamic acid | 74644-66-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: N-((S)-10-formyl-5,6,7,8-tetrahydro-pteroyl)-L-glutamic acid
• 英文别名: N-((S)-10-Formyl-5,6,7,8-tetrahydro-pteroyl)-L-glutaminsaeure；10-formyl-(6R)-tetrahydrofolic acid；10-formyltetrahydrofolate；N-(10-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid；(2S)-2-[[4-[[(6R)-2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl]methyl-formylamino]benzoyl]amino]pentanedioic acid
• CAS: 74644-66-9
• 化学式: C₂₀H₂₃N₇O₇
• 分子量: 473.445
• InChiKey: AUFGTPPARQZWDO-YPMHNXCESA-N

物化性质

• 密度：
  1.68±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  216
• 氢给体数：
  7
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  N-((S)-10-formyl-5,6,7,8-tetrahydro-pteroyl)-L-glutamic acid 在 盐酸 、 ammonium acetate 、 2-巯基乙醇 作用下， 生成 (6R)-5,10-methenyltetrahydrofolic acid chloride
  参考文献：
  名称：

  Methenyltetrahydrofolate Cyclohydrolase Catalyzes the Synthesis of (6S)-5-Formyltetrahydrofolate

  摘要：

  The methenyltetrahydrofolate cyclohydrolase activity of the bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase domain catalyzes the conversion of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. We have observed that in the presence of this domain, 10-formyltetrahydrofolate is converted to 5-formyltetrahydrofolate. The effects of nucleotide analogs on the initial rates of this reaction were found to be similar to their effects on the cyclohydrolase activity, establishing that 5-formyltetrahydrofolate production is dependent on the cyclohydrolase, The specific activity of 5-formyltetrahydrofolate production is approximately 7 X l0(4)-fold lower than that of the cyclohydrolase activity but can be used to obtain quantitative conversion of 10-formylH(4)folate to 5-formyltetrahydrofolate, in mg amounts. This ''side-reaction'' may contribute to the in vivo production of (6S)-5-formyltetrahydrofolate. (C) 1996 Academic Press, Inc.

  DOI：

  10.1006/bioo.1996.0020
• 作为产物：
  描述：

  tetrahydrofolic acid 、 sodium formate 在 human 10-formyltetrahydrofolate synthetase 、 potassium chloride 、 三乙醇胺盐酸盐 、 5’-三磷酸腺苷 、 2-巯基乙醇 、 sodium chloride 、 magnesium chloride 作用下， 以 水 为溶剂， 反应 4.5h， 生成 N-((S)-10-formyl-5,6,7,8-tetrahydro-pteroyl)-L-glutamic acid
  参考文献：
  名称：

  Methenyltetrahydrofolate Cyclohydrolase Catalyzes the Synthesis of (6S)-5-Formyltetrahydrofolate

  摘要：

  The methenyltetrahydrofolate cyclohydrolase activity of the bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase domain catalyzes the conversion of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. We have observed that in the presence of this domain, 10-formyltetrahydrofolate is converted to 5-formyltetrahydrofolate. The effects of nucleotide analogs on the initial rates of this reaction were found to be similar to their effects on the cyclohydrolase activity, establishing that 5-formyltetrahydrofolate production is dependent on the cyclohydrolase, The specific activity of 5-formyltetrahydrofolate production is approximately 7 X l0(4)-fold lower than that of the cyclohydrolase activity but can be used to obtain quantitative conversion of 10-formylH(4)folate to 5-formyltetrahydrofolate, in mg amounts. This ''side-reaction'' may contribute to the in vivo production of (6S)-5-formyltetrahydrofolate. (C) 1996 Academic Press, Inc.

  DOI：

  10.1006/bioo.1996.0020

文献信息

• [EN] 1 -OXO-1,2-DIHYDROISOQUINOLIN-7-YL-(5-SUBSTITUTED-THIOPHEN-2-YL)-SULFONAMIDE COMPOUNDS, FORMULATIONS CONTAINING THOSE COMPOUNDS, AND THEIR USE AS AICARFT INHIBITORS IN THE TREATMENT OF CANCERS<br/>[FR] COMPOSÉS 1-OXO-1,2-DIHYDROISOQUINOLÉINE-7-YL-(5-SUBSTITUÉ-THIOPHÉN-2-YL)-SULFONAMIDE, FORMULATIONS CONTENANT CES COMPOSÉS ET LEUR UTILISATION COMME INHIBITEURS D'AICARFT DANS LE TRAITEMENT DE CANCERS
  申请人：LILLY CO ELI

  公开号：WO2016089670A1

  公开（公告）日：2016-06-09

  1-Oxo-1,2-dihydroisoquinolin-7-yl-(5-substituted-thiophen-2-yl)-sulfonamide compounds, formulations containing those compounds, and their use as AICARFT inhibitors.

  1-Oxo-1,2-二氢异喹啉-7-基-(5-取代噻吩-2-基)-磺酰胺化合物，含有这些化合物的配方，以及它们作为AICARFT抑制剂的用途。
• CONJUGATED PROTEINS AND USES THEREOF
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：US20200278355A1

  公开（公告）日：2020-09-03

  Disclosed herein, in certain embodiments, are protein-probe adducts and synthetic ligands that inhibit protein-probe adduct formation, in which the proteins are regulated by NRF2. In some instances, also described herein are protein-binding domains that interact with a probe and/or a ligand described herein, in which the proteins are regulated by NRF2.

  在某些实施例中，本文披露了蛋白质探针加合物和合成配体，可以抑制蛋白质探针加合物的形成，其中这些蛋白质受NRF2调控。在某些情况下，本文还描述了与本文描述的探针和/或配体相互作用的蛋白结合结构域，其中这些蛋白质受NRF2调控。
• MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS
  申请人：Genomatica, Inc.

  公开号：US20150148513A1

  公开（公告）日：2015-05-28

  The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, 1,4-butanediol, or other product pathway and being capable of producing 4-hydroxybutyrate, 1,4-butanediol, or other product, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, 1,4-butanediol, or other product or related products using the microbial organisms.

  该发明提供了具有4-羟基丁酸、1,4-丁二醇或其他产物途径并能够产生4-羟基丁酸、1,4-丁二醇或其他产物的非自然微生物生物体，其中该微生物生物体包括一个或多个基因修饰。该发明还提供了利用这些微生物生物体生产4-羟基丁酸、1,4-丁二醇或其他产物或相关产品的方法。
• SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON
  申请人：Daiichi Sankyo Company, Limited

  公开号：US20190284198A1

  公开（公告）日：2019-09-19

  Provided is a novel compound or a salt thereof inhibiting MTHFD2 and useful for treating a disease caused by overexpression of MTHFD2, a disease involved in overexpression of MTHFD2 and/or a disease associated with overexpression of MTHFD2. Solution Provided is a sulfonamide derivative having a coumarin skeleton represented by the following formula (I) and having various substituents: wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are the same as defined in the specification, and a salt thereof.

  提供了一种新的化合物或其盐，用于抑制MTHFD2并用于治疗由MTHFD2过度表达引起的疾病，涉及MTHFD2过度表达的疾病和/或与MTHFD2过度表达相关的疾病。解决方案提供了一种具有以下式（I）所表示的香豆素骨架的磺胺衍生物，具有各种取代基：其中R1、R2、R3、R4、R5、R6和R7与规范中定义的相同，并且其盐。
• [EN] STABLE PRO-VITAMIN DERIVATIVE COMPOUNDS, PHARMACEUTICAL AND DIETARY COMPOSITIONS, AND METHODS OF THEIR USE<br/>[FR] COMPOSÉS DÉRIVÉS DE PRO-VITAMINES STABLES, COMPOSITIONS PHARMACEUTIQUES ET DIÉTÉTIQUES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV CORNELL

  公开号：WO2018009664A1

  公开（公告）日：2018-01-11

  The present invention relates to a compound of Formula I: [Formula should be inserted here], where R1, R2, and n are as described above, and pharmaceutically acceptable salts and solvates thereof. The present invention also relates to use of the above-noted compounds and compositions including those compounds.

  本发明涉及一种化合物I的公式：[应在此处插入公式]，其中R1，R2和n如上所述，并且其药学上可接受的盐和溶剂化物。本发明还涉及上述化合物及包括这些化合物的组合物的用途。