N'-tert-butyl-N-methyl-N-(trimethylsilylmethyl)methanimidamide | 80376-66-5

• 物质功能分类: 化学试剂 - 有机试剂 - 亚氨、脒
• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N'-tert-butyl-N-methyl-N-(trimethylsilylmethyl)methanimidamide
• CAS: 80376-66-5
• 化学式: C₁₀H₂₄N₂Si
• 分子量: 200.399
• InChiKey: MFQDMLNXILAMOB-DHZHZOJOSA-N

物化性质

• 沸点：
  78-80 °C (7 mmHg)
• 稳定性/保质期：
  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  2.62
• 重原子数：
  13.0
• 可旋转键数：
  3.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  15.6
• 氢给体数：
  0.0
• 氢受体数：
  1.0

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S36/37
• 危险类别码：
  R20/21/22
• 储存条件：
  存放在0至6°C的阴凉干燥处。

SDS

Name:	N-Methyl-N-Trimethylsilylmethyl-N'-Tert-Butyl Formamidine Material Safety Data Sheet
Synonym:	Meyers reagent
CAS:	80376-66-5

Section 1 - Chemical Product MSDS Name: N-Methyl-N-Trimethylsilylmethyl-N'-Tert-Butyl Formamidine Material Safety Data Sheet
Synonym: Meyers reagent

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SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
80376-66-5	N-Methyl-N-Trimethylsilylmethyl-N'-Ter	ca 100	unlisted

Hazard Symbols: XN
Risk Phrases: 20/21/22

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SECTION 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Harmful by inhalation, in contact with skin and if swallowed.The toxicological properties of this material have not been fully investigated. Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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SECTION 4 - FIRST AID MEASURES
Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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SECTION 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Cool containers with flooding quantities of water until well after fire is out. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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SECTION 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as sawdust. Provide ventilation.

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SECTION 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep refrigerated. (Store below 4C/39F.)

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SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 80376-66-5: Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: colorless
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 78 - 80 deg C @ 7.00mm Hg
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: soluble in chloroform, dichloromethane,
Specific Gravity/Density:
Molecular Formula: C10H24N2Si
Molecular Weight: 200.40

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SECTION 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide, oxides of silicon.
Hazardous Polymerization: Has not been reported

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SECTION 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 80376-66-5 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
N-Methyl-N-Trimethylsilylmethyl-N'-Tert-Butyl Formamidine - Not listed by ACGIH, IARC, or NTP.

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SECTION 12 - ECOLOGICAL INFORMATION

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SECTION 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations.

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SECTION 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material.

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SECTION 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
Safety Phrases:
S 28A After contact with skin, wash immediately with plenty of water. S 36/37 Wear suitable protective clothing and gloves. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 80376-66-5: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 80376-66-5 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 80376-66-5 is not listed on the TSCA inventory. It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
MSDS Creation Date: 4/05/1997 Revision #4 Date: 3/18/2003 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  N'-tert-butyl-N-methyl-N-(trimethylsilylmethyl)methanimidamide 在 盐酸 、 sodium tetrahydroborate 、 正丁基锂 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 1.0h， 生成 N-tert-Butyl-N'-methyl-N'-(1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methanediamine
  参考文献：
  名称：

  Enamidines. Versatile vehicles for homologation of carbonyl compounds

  摘要：

  DOI：

  10.1021/ja00367a052
• 作为产物：
  描述：

  三甲基氯硅烷 、 N,N-dimethyl tert-butylamino-formamidine 在 仲丁基锂 作用下， 以 四氢呋喃 为溶剂， 以89.2%的产率得到N'-tert-butyl-N-methyl-N-(trimethylsilylmethyl)methanimidamide
  参考文献：
  名称：

  Enamidines. Versatile vehicles for homologation of carbonyl compounds

  摘要：

  DOI：

  10.1021/ja00367a052

文献信息

• Formamidine anions in synthesis. The one-carbon homologation of aldehydes and ketones to nitriles
  作者：Braulio Santiago、A.I. Meyers

  DOI：10.1016/s0040-4039(00)73793-2

  日期：1993.9

  Treatment of various carbonyl compounds with the carbanion of the 2-trimethylsilymethyl formamidine 2 gives the enamidine 3 which is readily transformed into the homologated nitriles 6.

  与2 trimethylsilymethyl甲脒的负碳离子的各种羰基化合物的治疗2给出了enamidine 3被容易地转化为同系化腈6。
• MEYERS, A. I.;JAGDMANN, G. E. ,, JR, J. AMER. CHEM. SOC., 1982, 104, N 3, 877-879
  作者：MEYERS, A. I.、JAGDMANN, G. E. ,, JR

  DOI：——

  日期：——
• Enamidines. Versatile vehicles for homologation of carbonyl compounds
  作者：A. I. Meyers、G. Erik Jagdmann

  DOI：10.1021/ja00367a052

  日期：1982.2