sesamyl n-propylether | 87590-42-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: sesamyl n-propylether
• 英文别名: 5-propoxy-benzo[1,3]dioxole；5-Propoxy-benzo[1,3]dioxol；1,3-Benzodioxole, 5-propoxy-；5-propoxy-1,3-benzodioxole
• CAS: 87590-42-9
• 化学式: C₁₀H₁₂O₃
• mdl: MFCD26391030
• 分子量: 180.203
• InChiKey: WEZFPHYHXDVBGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  胡椒醛 在 过氧乙酸 、 氢氧化钾 、 对甲苯磺酸 、 溶剂黄146 作用下， 生成 sesamyl n-propylether
  参考文献：
  名称：

  Insecticide Synergists, 3,4-Methylenedioxyphenoxy Compounds as Synergists for Natural and Synthetic Pyrethrins

  摘要：

  DOI：

  10.1021/jf60059a002

文献信息

• [EN] PYRROLOPYRIMIDINECARBOXAMIDES<br/>[FR] PYRROLOPYRIMIDINE CARBOXAMIDES
  申请人：NYCOMED GMBH

  公开号：WO2009106531A1

  公开（公告）日：2009-09-03

  The compounds of Formula (I) wherein R1, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the N-oxides of the compounds and the salts thereof and the stereoisomers of the compounds, the salts, the N-oxides of the compounds and the N-oxides of the salts thereof are effective inhibitors of the type 5 phosphodiesterase.

  Formula（I）中的化合物，其中R1、R21、R22、R23、R24、Y和R3的含义如描述中所述，其盐，化合物的N-氧化物及其盐，化合物的立体异构体，盐，化合物的N-氧化物及其盐的N-氧化物是有效的第5型磷酸二酯酶抑制剂。
• Pyridyl Non-Aromatic Nitrogen-Containing Heterocyclic-1-Carboxylate Compound
  申请人：Ishii Takahiro

  公开号：US20100009971A1

  公开（公告）日：2010-01-14

  A novel pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound or its pharmaceutically acceptable salt has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound of the present disclosure is also useful in the treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.

  一种新型的吡啶基非芳香性含氮杂环-1-羧酸酯化合物或其药学上可接受的盐具有强效的FAAH抑制活性。此外，本公开的吡啶基非芳香性含氮杂环-1-羧酸酯化合物也可用于治疗尿频、尿失禁、过度活跃的膀胱和/或疼痛。
• Pyridyl Non-Aromatic Nitrogen-Containing Heterocyclic-1-Carboxylate Derivative
  申请人：Ishii Takahiro

  公开号：US20080306046A1

  公开（公告）日：2008-12-11

  [Problem] To provide a compound usable for treatment of diseases associated with fatty acid amide hydrolase (FAAH), especially for treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain. [Means for Solution] We have found that a novel pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivative and its pharmaceutically acceptable salt has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivative of the present invention has an excellent effect for increasing an effective bladder capacity, an excellent effect for relieving urinary frequency and an excellent anti-allodynia effect, and is therefore usable for treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.

  [问题] 提供一种可用于治疗与脂肪酸酰胺水解酶（FAAH）相关的疾病的化合物，特别是用于治疗尿频和尿失禁、过度活跃的膀胱和/或疼痛。 [解决方法] 我们发现一种新型的吡啶基非芳香性含氮杂环-1-羧酸酯衍生物及其药学上可接受的盐具有强效的FAAH抑制活性。此外，本发明的吡啶基非芳香性含氮杂环-1-羧酸酯衍生物具有优异的增加有效膀胱容量的效果，优异的缓解尿频的效果和优异的抗痛觉过敏效果，因此可用于治疗尿频和尿失禁、过度活跃的膀胱和/或疼痛。
• Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines
  申请人：Stadlwieser Josef

  公开号：US08445501B2

  公开（公告）日：2013-05-21

  The compounds of Formula (I), in which R1, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the N-oxides of the compounds and the salts thereof and the stereoisomers of the compounds, the salts, the N-oxides of the compounds and the N-oxides of the salts thereof are effective inhibitors of the type 5 phosphodiesterase.

  式（I）的化合物，其中R1、R21、R22、R23、R24、Y和R3的含义如所述，其盐，化合物的N-氧化物及其盐和化合物的立体异构体，盐，化合物的N-氧化物和其盐的N-氧化物是有效的5型磷酸二酯酶抑制剂。
• PYRROLOPYRIMIDINECARBOXAMIDES
  申请人：Stadlwieser Josef

  公开号：US20110021479A1

  公开（公告）日：2011-01-27

  The compounds of Formula (I), in which R1, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the N-oxides of the compounds and the salts thereof and the stereoisomers of the compounds, the salts, the N-oxides of the compounds and the N-oxides of the salts thereof are effective inhibitors of the type 5 phosphodiesterase.

  公式（I）的化合物，其中R1，R21，R22，R23，R24，Y和R3的含义如描述中所述，其盐，化合物的N-氧化物及其盐和化合物的立体异构体，盐，化合物的N-氧化物和其盐的N-氧化物是有效的5型磷酸二酯酶抑制剂。