2-phenoxypropene | 698-91-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-phenoxypropene
• 英文别名: Phenylisopropenylether；isopropenyl phenyl ether；2-Phenoxy-propen；Benzene, [(1-methylethenyl)oxy]-；prop-1-en-2-yloxybenzene
• CAS: 698-91-9
• 化学式: C₉H₁₀O
• 分子量: 134.178
• InChiKey: RISDDVKHYROMNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-phenoxypropene 在 乙醇 、 硫酸 、 铂 作用下， 生成 异丙苯酚
  参考文献：
  名称：

  The Rearrangement of Alkenyl Phenyl and Cresyl Ethers and the Syntheses of Isopropenyl Phenols and their Reduction Products¹

  摘要：

  DOI：

  10.1021/ja01328a034
• 作为产物：
  描述：

  potassium cumyl peroxide 在 三聚氯氰 作用下， 生成 2-phenoxypropene
  参考文献：
  名称：

  有机过氧化物—XIX 1：三烷基过氧三嗪的分解

  摘要：

  三-叔丁基过氧化-1,3,5-三嗪的分解的动力学（从三氯-1,3,5-三嗪和钡叔丁基过氧化物的原位）如下所述1次24.6活化能。分离的产物是氰尿酸和丙酮。三氯三嗪与过氧化枯基钾反应生成氰尿酸，异丙烯基苯基醚，过氧化二枯基，丙酮和苯酚，与过氧化2-苄基-2-丙基过氧化钡氰尿酸，苯甲醛和2-苄氧基-2- [2-苄基] -2-丙基过氧]-丙烷。讨论了分解的机理。

  DOI：

  10.1016/0040-4020(78)80152-5

文献信息

• Stiff-Person Syndrome: Autoimmunity and the Central Nervous System
  作者：Beth Brianna Murinson、Angela Vincent

  DOI：10.1017/s1092852900021805

  日期：2001.11

  Stiff-person syndrome (SPS) is a rare disease of severe progressive muscle stiffness in the spine and lower extremities with superimposed muscle spasms triggered by external stimuli. Patients with SPS are often referred for psychiatric evaluation and the psychiatrist may be the first to diagnosis SPS. Psychosocial stressors often precede the first manifestations of the disease; depression, anxiety, and alcohol abuse are comorbid illnesses. The identification of an association with antibodies to glutamic acid decarboxylase (GAD) was invaluable for definitively establishing a pathological basis for the disease; antibodies to amphiphysin and gephyrin are also found in cases of SPS but at much lower frequencies. Whether the antibodies inhibit GAD activity in vivo, target GAD-expressing neurons for immune-mediated destruction, are part of a wider immune process, or are merely a marker for destruction of GAD-expressing neurons by an independent neurodegenerative process is not yet clear. Both electromyography and the detection of GAD antibodies are useful in establishing a diagnosis of SPS. Treatment of SPS includes the use of immunomodulating therapies (plasmapheresis and intravenous immunoglobulins) and symptomatic treatment with benzodiazepines and baclofen. The use of tricyclic antidepressants and rapid withdrawal from therapy should be avoided.

  摘要僵人综合征（SPS）是一种罕见的疾病，患者脊柱和下肢会出现严重的进行性肌肉僵硬，并伴有由外部刺激引发的肌肉痉挛。SPS 患者通常会被转介到精神科进行评估，精神科医生可能是诊断 SPS 的第一人。心理社会压力往往先于疾病的最初表现；抑郁、焦虑和酗酒是合并症。与谷氨酸脱羧酶（GAD）抗体相关性的鉴定对于明确确定该病的病理基础非常有价值；在SPS病例中也可发现氨肽素和胰蛋白酶抗体，但频率要低得多。这些抗体是在体内抑制 GAD 的活性，还是针对 GAD 表达的神经元进行免疫介导的破坏，是更广泛的免疫过程的一部分，或者仅仅是独立的神经退行性过程破坏 GAD 表达的神经元的标志物，目前还不清楚。肌电图和 GAD 抗体的检测都有助于确诊 SPS。SPS 的治疗包括使用免疫调节疗法（浆细胞吸出术和静脉注射免疫球蛋白）以及苯二氮卓类药物和巴氯芬对症治疗。应避免使用三环类抗抑郁药和快速停药。
• [EN] PRODRUGS OF MITOCHODRIA-TARGETING OLIGOPEPTIDES<br/>[FR] PROMÉDICAMENTS D'OLIGOPEPTIDES CIBLANT LA MITOCHODRIE
  申请人：STEALTH BIOTHERAPEUTICS CORP

  公开号：WO2021262708A1

  公开（公告）日：2021-12-30

  Disclosed are various prodrugs of Elamipretide.

  Elamipretide的各种前药已被披露。
• [EN] A METHOD FOR OBTAINING CRYSTALLINE LACTO-N-TETRAOSE AND LACTO-N-NEOTETRAOSE PRECURSORS AND MIXTURES THEREOF<br/>[FR] PROCÉDÉ POUR OBTENIR DES PRÉCURSEURS DE LACTO-N-TÉTRAOSE ET DE LACTO-N-NEOTÉTRAOSE CRISTALLIN ET DES MÉLANGES DE CEUX-CI
  申请人：GLYCOM AS

  公开号：WO2013091660A1

  公开（公告）日：2013-06-27

  A mixture of, preferably a mixture consisting essentially of, an lacto-N-tetraose (LNT) precursor (1) and an lacto-N-neotetraose (LNnT) precursor (2), (formula 1, 2), where R is a group removable by hydrogenolysis and R3 is either a group removable by hydrogenolysis or H, a method of crystallizing 1 and/or 2 from said mixture, and the use of said mixture for making a mixture consisting essentially of LNnT and LNT for use as a pharmaceutically or nutritionally active ingredient. The precursors can be made by reacting an acceptor of formula 5, (formula 5), wherein R is a group removable by hydrogenolysis, R1 is acyl, Ri is acyl or H, R3 is selected from a group removable by hydrogenolysis, acyl, silyl and an acetal type group and Y is selected from alkanoylamido, haloalkanoylamido, -NAc2, benzamido, alkoxycarbonylamino, haloalkoxycarbonylamino, benzyloxycarbonylamino, azido, phthalimido, tetrachlorophthalimido, 2,3- diphenylmaleimido and 2,3-dimethylmaleimido, with a donor of formula 6, (formula 6), wherein R4 is acyl and Xi is selected from halogen, -OC(=NH)CCl3, -OAc, -OBz or -SR5, wherein R5 is selected from alkyl, substituted phenyl and unsubstituted phenyl, followed by one or more deprotection steps.

  一种混合物，优选基本上由乳糖-N-四糖（LNT）前体（1）和乳糖-N-新四糖（LNnT）前体（2）（式1，2）组成，其中R是通过氢解可移除的基团，R3是可通过氢解移除的基团或H，从该混合物中结晶1和/或2的方法，以及该混合物用于制备基本上由LNnT和LNT组成的混合物，作为药用或营养活性成分的用途。这些前体可以通过反应一个受体式5（式5），其中R是通过氢解可移除的基团，R1是酰基，Ri是酰基或H，R3是从可通过氢解移除的基团、酰基、硅基和缩醛型基团中选择的，Y是从烷酰胺基、卤代烷酰胺基、-NAc2、苯甲酰胺基、烷氧羰基氨基、卤代烷氧羰基氨基、苄氧羰基氨基、叠氮基、邻苯二甲酰亚胺基、四氯邻苯二甲酰亚胺基、2,3-二苯基马来酰亚胺基和2,3-二甲基马来酰亚胺基中选择的，与一个供体式6（式6）反应，其中R4是酰基，Xi是从卤素、-OC(=NH)CCl3、-OAc、-OBz或-SR5中选择的，其中R5是从烷基、取代的苯基和未取代的苯基中选择的，随后进行一个或多个脱保护步骤来制备。
• Melting mechanism of a starved-fed single-screw extruder for calcium carbonate filled polyethylene
  作者：M. R. Thompson、G. Donoian、J. P. Christiano

  DOI：10.1002/pen.11334

  日期：2000.9

  A study of starved-fed single screw extrusion was initiated to understand the relation between its distinctive melting mechanism and the improved mixing capabilities attained during compounding of a calcium carbonate filler into HDPE. Experiments were carried out in a 63.5 mm single screw extruder, examining the effect of degree of starvation on a conventional and barrier feed screw. Interest was focused on the mixing/melting mechanism of starved-fed solids-conveying as it affects the size and number of filler agglomerates observed in the extrudate. The melting performance of both feed screws was examined using pressure and temperature measurements down the screw length as well as direct inspection of the polymer in the screw channel via rapid screw cooling. Both screws showed improved mixing quality with increased starvation.

  一项关于饥饿进料/饱料进料单螺杆挤出的研究旨在理解其独特的熔融机制与在将碳酸钙填料复合进高密度聚乙烯（HDPE）过程中达到的混合能力提升之间的关系。实验在一台63.5毫米单螺杆挤出机上进行，考察了饥饿程度对传统螺杆和屏障螺杆的影响。研究焦点集中在饥饿进料的固体输送混合/熔融机制上，因为它影响着挤出物中填料团聚体的大小和数量。通过沿螺杆长度方向的压力和温度测量，以及通过快速螺杆冷却对螺杆槽道内聚合物的直接检查，考察了两类螺杆的熔融性能。两种螺杆随着饥饿程度增加，混合质量均有所提升。
• Catalytic Dehydrogenation of<i>o</i>-Alkylated or<i>o</i>-Alkoxylated Iodoarenes with Concomitant Hydrogenolysis
  作者：Elena Motti、Marta Catellani

  DOI：10.1002/adsc.200700562

  日期：2008.3.7

  Palladium-catalyzed dehydrogenation of suitable chains bonded to an ortho position of an iodoarene has been achieved by two methods both involving oxidative addition of the iodoarene to palladium(0) and palladacycle formation under mild conditions.

  已通过两种方法实现了键合到碘芳烃邻位的合适链的钯催化脱氢，这两种方法均涉及将碘芳烃氧化加成至钯（0）和在温和条件下形成钯环。