2-phenyl-4-nitrobromobenzene | 489409-86-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-phenyl-4-nitrobromobenzene
• 英文别名: 2-bromo-5-nitro-1,1'-biphenyl；1-bromo-4-nitro-2-phenylbenzene
• CAS: 489409-86-1
• 化学式: C₁₂H₈BrNO₂
• 分子量: 278.105
• InChiKey: USXRNPQXEPBNDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-phenyl-4-nitrobromobenzene 在 乙醇 、 tin(ll) chloride 作用下， 生成 N-(6-bromo-biphenyl-3-yl)-acetamide
  参考文献：
  名称：

  The Preparation of 3,4-Dibromodiphenyl

  摘要：

  DOI：

  10.1021/ja01298a047
• 作为产物：
  描述：

  2'-bromo-[1,1'-biphenyl]-4-amine 在 硫酸 、 potassium nitrate 、 sodium nitrite 作用下， 生成 2-phenyl-4-nitrobromobenzene
  参考文献：
  名称：

  The Nitration of Certain Halobiphenyls. III. Nitro Derivatives of 2-Chloro- and 2-Bromobiphenyl

  摘要：

  DOI：

  10.1021/ja01251a033

文献信息

• INDENOTRIPHENYLENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME
  申请人：YEN FENG-WEN

  公开号：US20190194534A1

  公开（公告）日：2019-06-27

  The present invention discloses an indenotriphenylene phosphine oxide derivative and an organic electroluminescence device employing the derivative as the phosphorescent host material in the light emitting layer, and/or the hole blocking material and/or the electron transporting material in the organic EL device, which thereby exhibits improved performance.

  本发明公开了一种茚三苯基磷氧化物衍生物，以及一种使用该衍生物作为发光层中的磷光主体材料，以及/或在有机EL设备中的空穴阻挡材料和/或电子传输材料的有机电致发光器件，从而展现出改善的性能。
• Intramolecular Remote C–H Activation via Sequential 1,4-Palladium Migration To Access Fused Polycycles
  作者：Panpan Li、Qiuyu Li、He Weng、Jiaming Diao、Hequan Yao、Aijun Lin

  DOI：10.1021/acs.orglett.9b02392

  日期：2019.9.6

  conveyor has been described. This reaction provides an efficient route to construct diverse polycyclic frameworks in moderate to good yield via palladium-catalyzed remote C-H activation/alkene insertion, arylation, alkenylation, and the Heck reaction. The preliminary mechanistic studies revealed that the 1,4-palladium migration process was reversible.

  已经描述了空前的分子内远程CH活化，其通过以芳香环作为传送带的连续1,4-钯迁移来实现。该反应提供了一种有效的途径，可通过钯催化的远程CH活化/烯烃插入，芳基化，烯基化和Heck反应，以中等到良好的产率构建各种多环骨架。初步的机理研究表明，1,4-钯的迁移过程是可逆的。
• COMPOUND FOR ORGANIC ELECTROLUMINESCENT DEVICE
  申请人：LUMINESCENCE TECHNOLOGY CORPORATION

  公开号：US20160218293A1

  公开（公告）日：2016-07-28

  The present invention generally discloses an organic compound and organic electroluminescence (herein referred to as organic EL) device using the organic compound. More specifically, the present invention relates to an organic EL device employing the organic compound as fluorescent emitting host or phosphorescent emitting host which can display long lifetime, high efficiency.

  本发明一般公开了一种有机化合物和使用该有机化合物的有机电致发光（以下简称为有机EL）器件。更具体地说，本发明涉及一种使用该有机化合物作为荧光发射主体或磷光发射主体的有机EL器件，该器件可以显示出长寿命和高效率。
• Through the Maze: Cross-Coupling Pathways to a Helical Hexaphenyl “Geländer” Molecule
  作者：Michel Rickhaus、Linda Maria Bannwart、Oliver Unke、Heiko Gsellinger、Daniel Häussinger、Marcel Mayor

  DOI：10.1002/ejoc.201403322

  日期：2015.2

  highlights a new concept on how to induce chirality in a hexaphenyl GelA¤nder-type system. Bridging a terphenyl backbone with a considerably longer benzyl ether oligomer enforces a continuous twist of the molecule, while preventing an achiral meso form. By highlighting cross-coupling strategies and explored synthetic pathways, this report aims to serve as an Ariadne`s thread for the synthesis of precisely

  本文重点介绍了如何在六苯基 GelA?nder 型系统中诱导手性的新概念。用相当长的苄基醚低聚物桥接三联苯骨架可以强制分子的连续扭曲，同时防止非手性内消旋形式。通过突出交叉偶联策略和探索的合成途径，本报告旨在作为 Ariadne 的线索，用于合成精确功能化的复杂多环芳烃系统。概述了访问设计目标所需的综合挑战和注意事项，并提出了组装每个步骤的解决方案。遇到的异构化与合成工具一样被讨论，以获取具有多正交部分的高度官能化的中间体。
• Compounds and methods for the inhibition of compounds cruzi
  申请人：Hamilton D Andrew

  公开号：US20060167269A1

  公开（公告）日：2006-07-27

  The present invention relates to compounds according to the formula (I): Where R A is a C 1 -C 10 substituted or unsubstituted linear, branch-chained or cyclic alkyl or alkenyl group or a phenyl group according to the formula (II): R B is a C 1 -C 10 substituted or unsubstituted linear, branch-chained or cyclic alkyl or alkenyl group or a phenyl group of the formula (III): R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are each independently selected from H, C 1 -C 10 (preferably a C 1 -C 4 ) alkyl or alkenyl group, CF 3 , F, Cl, Br, I, CN, NO 2 , NH 2 , NHR, NRR, COR (acyl group), OR (hydroxyl or ether group), CO 2 R (carboxylic acid or ester group), or COSR (thioester group) where R is H or a C 1 -C 10 (preferably a C 1 -C 4 ) alkyl or alkenyl group, an unsubstituted or substituted aryl (preferably, phenyl) or heterocycle group, or a (IV) group, where R 3 is H, a C 1 -C 10 (preferably a C 1 -C 4 ) alkyl, alkenyl, ether or a thioether group; and R 11 and R 12 are independently selected from H or a C 1 -C 3 alkyl or alkenyl group, or a pharmaceutically acceptable salt thereof and methods for treating infections caused by protozoal, fungal and/or bacterial agents such as Trypanosoma cruzi, Mycobacterium spp., Leishmania spp., Cryptococcus spp., Aspergillus spp., Histoplasma spp., Candida spp., especially Candida albicans, Pneumocystis carinii, Trichophyton spp., Microsporum spp., Malassezia spp., Rhizopus spp., Pseudallescheria spp., Blastomyces dermatitidis and Coccidiodes spp., among others.

  本发明涉及式(I)的化合物：其中RA是C1-C10取代或未取代的线性、支链或环烷基或烯基或式(II)的苯基：RB是C1-C10取代或未取代的线性、支链或环烷基或烯基或式(III)的苯基：R1、R2、R3、R4、R5、R6、R7、R8、R9和R10各自独立地选自H、C1-C10(优选为C1-C4)烷基或烯基、CF3、F、Cl、Br、I、CN、NO2、NH2、NHR、NRR、COR（酰基）、OR（羟基或醚基）、CO2R（羧酸或酯基）或COSR（硫酯基），其中R是H或C1-C10(优选为C1-C4)烷基或烯基、未取代或取代的芳基（优选为苯基）或杂环基，或式(IV)的基团，其中R3是H、C1-C10(优选为C1-C4)烷基、烯基、醚或硫醚基；R11和R12各自独立地选自H或C1-C3烷基或烯基，或其药学上可接受的盐，以及用于治疗由原虫、真菌和/或细菌引起的感染的方法，例如Trypanosoma cruzi，Mycobacterium spp.，Leishmania spp.，Cryptococcus spp.，Aspergillus spp.，Histoplasma spp.，Candida spp.，特别是Candida albicans，Pneumocystis carinii，Trichophyton spp.，Microsporum spp.，Malassezia spp.，Rhizopus spp.，Pseudallescheria spp.，Blastomyces dermatitidis和Coccidioides spp.等。