(4R)-4-benzyl-3-[(2R)-2-fluoropentanoyl]-1,3-oxazolidin-2-one | 1448991-44-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (4R)-4-benzyl-3-[(2R)-2-fluoropentanoyl]-1,3-oxazolidin-2-one
• CAS: 1448991-44-3
• 化学式: C₁₅H₁₈FNO₃
• 分子量: 279.311
• InChiKey: NDOUUKZVIZFPKP-CHWSQXEVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (R)-4-benzyl-3-pentanoyloxazolidin-2-one 在 lithium hexamethyldisilazane 、 N-氟代双苯磺酰胺 作用下， 以 四氢呋喃 为溶剂， 以86%的产率得到
  参考文献：
  名称：

  Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor

  摘要：

  The application of meso-scale flow chemistry in research laboratories continues to increase. Here, we report on the use of a modular cryo-flow device as applied to a diastereoselective fluorination process. The reactor can be incorporated into existing flow chemistry setups to permit continuous processing at low temperatures without recourse to cryogenic consumables.

  DOI：

  10.1055/s-0033-1338455

文献信息

• Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor
  作者：Steven Ley、Keiji Nakayama、Duncan Browne、Ian Baxendale

  DOI：10.1055/s-0033-1338455

  日期：——

  The application of meso-scale flow chemistry in research laboratories continues to increase. Here, we report on the use of a modular cryo-flow device as applied to a diastereoselective fluorination process. The reactor can be incorporated into existing flow chemistry setups to permit continuous processing at low temperatures without recourse to cryogenic consumables.