1-hexadecyl-3-methyl pyridinium chloride | 14586-40-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-hexadecyl-3-methyl pyridinium chloride
• 英文别名: Pyridinium, 1-hexadecyl-3-methyl-, chloride；1-hexadecyl-3-methylpyridin-1-ium;chloride
• CAS: 14586-40-4
• 化学式: C₂₂H₄₀N*Cl
• 分子量: 354.019
• InChiKey: HKTSAUQXXZHFRT-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.77
• 重原子数：
  24
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-甲基吡啶 、 氯代十六烷 以122 g的产率得到1-hexadecyl-3-methyl pyridinium chloride
  参考文献：
  名称：

  [EN] AN IMPROVED PROCESS FOR THE PRODUCTION OF QUATERNARY PYRIDINIUM SALTS
  [FR] PROCÉDÉ AMÉLIORÉ POUR LA PRODUCTION DE SELS DE PYRIDINIUM QUATERNAIRE

  摘要：

  本文披露了一种在工业规模下以高产率和纯度生产季铵吡啶盐及其水合物的成本效益和环保过程。

  公开号：

  WO2016092499A1

文献信息

• METHOD FOR PRODUCING OPTICALLY ACTIVE DIAMINE DERIVATIVE
  申请人：Kawanami Koutarou

  公开号：US20120035369A1

  公开（公告）日：2012-02-09

  The problem to be solved is to provide an important intermediate for production of an FXa inhibitor. The solution thereto is a method for industrially producing a compound (1) or a compound (4), comprising: [Step 1]: adding a quaternary ammonium salt and a metal azide salt to water to prepare an aqueous solution of an azidification reagent complex comprising quaternary ammonium salt-metal azide salt, and subsequently dehydrating the aqueous solution using an aromatic hydrocarbon solvent to form a mixed solution of the azidification reagent complex comprising quaternary ammonium salt-metal azide salt and the aromatic hydrocarbon solvent with a water content of 0.2% or less; and [Step 2]: adding, to the mixed solution prepared in [Step 1], a compound (2) wherein L represents a leaving group.

  要解决的问题是提供生产FXa抑制剂的重要中间体。解决方案是一种工业生产化合物（1）或化合物（4）的方法，包括：[步骤1]：将季铵盐和金属偶氮盐加入水中，制备含季铵盐-金属偶氮盐的偶氮化试剂复合物的水溶液，随后使用芳香烃溶剂脱水水溶液，形成含季铵盐-金属偶氮盐的偶氮化试剂复合物和芳香烃溶剂的混合溶液，水含量为0.2％或以下; [步骤2]：向[步骤1]中制备的混合溶液中加入化合物（2），其中L表示离去基团。
• Process for preparing di-tert.-butyl dicarbonate
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0468404A2

  公开（公告）日：1992-01-29

  Di-tert.-butyl dicarbonate having a high purity is prepared by reacting alkali metal tert.-butyl carbonate with methanesulfonyl chloride optionally in the presence of a phase transfer catalyst or an aromatic amine.

  高纯度的二碳酸二叔丁酯是通过碱金属碳酸叔丁酯与甲磺酰氯（可选择在相转移催化剂或芳香胺存在下）反应制备的。
• MODIFIED AMADORIASE AND METHOD FOR PRODUCING SAME, AGENT FOR IMPROVING SURFACTANT-RESISTANCE OF AMADORIASE AND COMPOSITION FOR MEASURING HbA1c USING SAME
  申请人：Kikkoman Corporation

  公开号：EP3031914A1

  公开（公告）日：2016-06-15

  Provided is a composition by which glycated hemoglobin can be measured even in the presence of a stronger surfactant than a conventional case. Also provided is a buffer and/or stabilizer which maintains the residual activity of an amadoriase or lowers a reduction of residual activity. The present invention provides a composition for use in measuring glycated hemoglobin containing an amadoriase having substitution of one or more amino acid residues at a position(s) corresponding to an amino acid(s) selected from the group consisting of position 262, position 257, position 249, position 253, position 337, position 340, position 232, position 129, position 132, position 133, position 44, position 256, position 231 and position 81 of an amadoriase derived from the genus Coniochaeta and represented by SEQ ID No: 1 or 3, and having residual activity even in the presence of a surfactant. The present invention also provides a composition and kit for use in measuring glycated hemoglobin, comprising a specific stabilizer and/or a buffer. The present invention can provide an enzyme and a composition for use in measuring glycated hemoglobin, excellent in storage stability even if they are exposed to a surfactant.

  本发明提供了一种即使在表面活性剂强于常规情况下也能测定糖化血红蛋白的组合物。本发明还提供了一种缓冲剂和/或稳定剂，可保持氨甲蝶呤酶的残余活性或降低残余活性的降低。本发明提供了一种用于测定糖化血红蛋白的组合物，该组合物含有在与选自 Coniochaeta 属并由 SEQ ID No：1 或 3 所代表的氨甲蝶呤酶，即使在表面活性剂存在的情况下也具有残余活性。本发明还提供了一种用于测量糖化血红蛋白的组合物和试剂盒，其中包含一种特定的稳定剂和/或缓冲剂。本发明可提供一种酶和一种用于测量糖化血红蛋白的组合物，即使它们暴露于表面活性剂中，也具有极佳的储存稳定性。
• HEMOGLOBIN A1c MEASUREMENT METHOD AND MEASUREMENT KIT
  申请人：Kikkoman Corporation

  公开号：EP3061819A1

  公开（公告）日：2016-08-31

  This invention provides an amadoriase that acts on the β-chain of hemoglobin A1c (HbA1c) and generates hydrogen peroxide, a method for measurement of HbA1c using such amadoriase, and a reagent kit for measurement of HbAlc using such amadoriase. The method for measurement of HbAlc involves the use of an amadoriase that has specific activity of 0.1 U/mg or greater to αF6P and oxidizes the HbA1c β-chain amino terminus so as to generate hydrogen peroxide, and the reagent kit for measurement of HbA1c comprises such amadoriase. The method and the kit for measurement of HbAlc enable quantification of HbAlc to be performed rapidly, simply, and accurately.

  本发明提供了一种作用于血红蛋白A1c(HbA1c)β链并生成过氧化氢的氨甲蝶呤酶，一种使用这种氨甲蝶呤酶测量HbA1c的方法，以及一种使用这种氨甲蝶呤酶测量HbAlc的试剂盒。测量 HbAlc 的方法包括使用一种对 αF6P 的比活度为 0.1 U/mg 或更高的、氧化 HbA1c β 链氨基末端以产生过氧化氢的氨甲蝶呤酶，测量 HbA1c 的试剂盒包括这种氨甲蝶呤酶。该方法和试剂盒可快速、简单、准确地测定 HbAlc。
• AMADORIASE HAVING IMPROVED ANIONIC-SURFACTANT RESISTANCE
  申请人：Kikkoman Corporation

  公开号：EP3216865A1

  公开（公告）日：2017-09-13

  The present invention provides a composition that enables measurement of glycated hemoglobin in the presence of a stronger surfactant than conventional surfactants. To this end, the present invention provides an amadoriase in which one or more amino acids have been substituted at positions corresponding to positions selected from the group consisting of positions 80, 71, 175, 172, 279, 12, 9, 77, 30, 28, 13, 3, 4, 286, 204, 338, 44, 340, and 194 of the amadoriase derived from the genus Coniochaeta having the amino acid sequence as shown in SEQ ID NO: 1 as well as a composition for measurement of glycated hemoglobin comprising an amadoriase that retains activity in the presence of an anionic surfactant. The present invention can provide an enzyme and a composition for measurement of glycated hemoglobin that sufficiently remain stable even when exposed to anionic surfactants.

  本发明提供了一种组合物，该组合物能够在比传统表面活性剂更强的表面活性剂存在下测量糖化血红蛋白。为此，本发明提供了一种氨甲蝶呤酶，其中一个或多个氨基酸在与选自具有 SEQ ID NO：1 所示氨基酸序列的氨甲蝶呤酶，以及一种用于测量糖化血红蛋白的组合物，该组合物包含一种在阴离子表面活性剂存在下仍能保持活性的氨甲蝶呤酶。本发明可提供一种用于测量糖化血红蛋白的酶和组合物，即使暴露于阴离子表面活性剂中也能充分保持稳定。