1-amino-3-(2-hydroxy-phenoxy)-propan-2-ol | 22530-55-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-amino-3-(2-hydroxy-phenoxy)-propan-2-ol
• 英文别名: 2-(3-Amino-2-hydroxypropoxy)phenol
• CAS: 22530-55-8
• 化学式: C₉H₁₃NO₃
• 分子量: 183.207
• InChiKey: BZVHVRVBYPQBCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  75.7
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氨 作用下， 生成 1-amino-3-(2-hydroxy-phenoxy)-propan-2-ol 、 2-羟基甲基-1,4-苯二恶
  参考文献：
  名称：

  表氯醇与一元酚和邻苯二酚的缩合

  摘要：

  DOI：

  10.1039/jr9540001571

文献信息

• 1-Amido-3-(2-hydroxyphenoxy)-2-propanol derivatives and a process for preparing 2-amidomethyl-1,4-benzodioxane derivatives
  申请人：Miki Yasushi

  公开号：US20060019993A1

  公开（公告）日：2006-01-26

  An 1-amido-3-(2-hydroxyphenoxy)-2-propanol derivative represented by the following formula (1), wherein cycle A may have further 1 to 4 substituents, and said substituent means a substituent selected from the group consisting of saturated or unsaturated C1-4 alkyl group, aralkyl group in which alkyl moiety has 1 to 4 carbon atoms, aryl group, halogen atom, halogenated C1-4 alkyl group, C2-5 alkanoyl group, mono or dialkylcarbamoyl group in which alkyl moiety has 1 to 4 carbon atoms, cyano group and nitro group, and the substituents at positions 3 and 6, or at positions 4 and 5 on the cycle A are different each other. Other ring may be fused at positions 3 and 4, or at positions 5 and 6 on the cycle A to form a condensed polycyclic hydrocarbon with the cycle A. R 1 is alkanoyl group or aroyl group, and R 2 is hydrogen atom, alkanoyl group or aroyl group, or R 1 and R 2 may be combined together with the N atom to form a cyclic imido group, which is useful as an intermediate of medicines, etc.

  由以下公式（1）表示的1-酰胺-3-(2-羟基苯氧基)-2-丙醇衍生物，其中环A可能有进一步的1到4个取代基，所述取代基是从饱和或不饱和的C1-4烷基，含有1到4个碳原子的芳基烷基，芳基，卤素原子，卤代C1-4烷基，C2-5烷酰基，单或二烷基氨基基，其中烷基部分含有1到4个碳原子，氰基和硝基中选择的取代基，并且在环A上的位置3和6，或在位置4和5上的取代基彼此不同。其他环可能在环A上的位置3和4，或在位置5和6上与环A融合，形成与环A的紧缩多环碳氢化合物。R1是烷酰基或芳酰基，R2是氢原子，烷酰基或芳酰基，或R1和R2可以与N原子结合在一起形成环亚胺基团，可用作药物等的中间体。
• 1-amido-3-(2-hydroxyphenoxy)-2-propanol derivatives and a process for preparing 2-amidomethyl-1, 4-benzodioxane derivatives
  申请人：DAISO CO., LTD.

  公开号：EP1619183A3

  公开（公告）日：2006-04-19

  An 1-amido-3-(2-hydroxyphenoxy)-2-propanol derivative represented by the following formula (1),     wherein cycle A may have further 1 to 4 substituents, and said substituent means a substituent selected from the group consisting of saturated C1-4 alkyl group or unsaturated C2-4 alkyl group, aralkyl group in which alkyl moiety has 1 to 4 carbon atoms, C6-12 aryl group, halogen atom, halogenated C1-4 alkyl group, C2-5 alkanoyl group, mono or dialkylcarbamoyl group in which alkyl moiety has 1 to 4 carbon atoms, cyano group and nitro group, and the substituents at positions 3 and 6, or at positions 4 and 5 on the cycle A are different each other, and wherein another ring may be fused at positions 3 and 4, or at positions 5 and 6 to the cycle A to form a condensed polycyclic hydrocarbon with the cycle A and wherein R1 is C2-5 alkanoyl group or C7-12 aroyl group, and R2 is hydrogen atom, C2-5 alkanoyl group or C7-12 aroyl group, or R1 and R2 may be combined with the N atom to form a cyclic imido group, which is useful as an intermediate of medicines, etc.

  由下式(1)代表的 1-氨基-3-(2-羟基苯氧基)-2-丙醇衍生物、 其中循环 A 可进一步具有 1 至 4 个取代基，所述取代基指选自以下组别的取代基：饱和 C1-4 烷基或不饱和 C2-4 烷基、其中烷基具有 1 至 4 个碳原子的芳烷基、C6-12 芳基、卤素原子、卤代 C1-4 烷基、C2-5 烷酰基、其中烷基具有 1 至 4 个碳原子的单烷基或二烷基氨基甲酰基、氰基和硝基、其中 R1 为 C2-5 烷酰基或 C7-12 芳基，R2 为氢原子、C2-5 烷酰基或 C7-12 芳基，或 R1 和 R2 可与 N 原子结合形成环状亚氨基、 可用作药物等的中间体。
• JP2006028110A
  申请人：——

  公开号：JP2006028110A

  公开（公告）日：2006-02-02
• US7368608B2
  申请人：——

  公开号：US7368608B2

  公开（公告）日：2008-05-06