[4-(4-oxo-3-phenyl-2-phenyliminothiazolidin-5-ylidenemethyl)phenoxy]acetic acid | 328268-69-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [4-(4-oxo-3-phenyl-2-phenyliminothiazolidin-5-ylidenemethyl)phenoxy]acetic acid
• 英文别名: [4-(4-Oxo-3-phenyl-2-phenylimino-thiazolidin-5-ylidenemethyl)-phenoxy]-acetic acid；2-[4-[(4-oxo-3-phenyl-2-phenylimino-1,3-thiazolidin-5-ylidene)methyl]phenoxy]acetic acid
• CAS: 328268-69-5
• 化学式: C₂₄H₁₈N₂O₄S
• mdl: MFCD00615268
• 分子量: 430.484
• InChiKey: LLKMHYDZDXYSDG-UHFFFAOYSA-N

物化性质

• 沸点：
  641.1±65.0 °C(Predicted)
• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N,N'-二苯基硫脲 在 sodium acetate 、 溶剂黄146 、 β-丙氨酸 作用下， 以 乙醇 为溶剂， 反应 4.0h， 生成 [4-(4-oxo-3-phenyl-2-phenyliminothiazolidin-5-ylidenemethyl)phenoxy]acetic acid
  参考文献：
  名称：

  Synthesis of novel 4-thiazolidione derivatives as antibacterial agents against drug-resistant Staphylococcus epidermidis

  摘要：

  A series of novel substituted 4-thiazolidione derivatives were designed, synthesized, and evaluated in vitro for their antibacterial activities, in comparison with methicillin and ampicillin. Compounds (7d, 7h-k) exhibit good potency in inhibiting the growth of Staphylococcus epidermidis (MIC: 1.57-3.13 mu M). Further antibacterial effects of compounds (7d, 7h-k) were investigated using clinical isolates (methicillin-resistant Staphylococcus epidermidis and methicillin-resistant Staphylococcus aureus), in comparison with methicillin and levofloxacin. Compound 7k showed the most potent antibacterial activities among the synthesized compounds.

  DOI：

  10.1007/s00044-012-0363-9

文献信息

• Synthesis of novel 4-thiazolidione derivatives as antibacterial agents against drug-resistant Staphylococcus epidermidis
  作者：Dan Zhao、Huayong Liu、Likang Zheng、Guozhen He、Di Qu、Shiqing Han

  DOI：10.1007/s00044-012-0363-9

  日期：2013.8

  A series of novel substituted 4-thiazolidione derivatives were designed, synthesized, and evaluated in vitro for their antibacterial activities, in comparison with methicillin and ampicillin. Compounds (7d, 7h-k) exhibit good potency in inhibiting the growth of Staphylococcus epidermidis (MIC: 1.57-3.13 mu M). Further antibacterial effects of compounds (7d, 7h-k) were investigated using clinical isolates (methicillin-resistant Staphylococcus epidermidis and methicillin-resistant Staphylococcus aureus), in comparison with methicillin and levofloxacin. Compound 7k showed the most potent antibacterial activities among the synthesized compounds.