6-bromo-4-(4-bromophenyl)-2-methyl-N-propyl-1,4-dihydro-1,8-naphthyridine-3-carboxamide | 1197180-32-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-bromo-4-(4-bromophenyl)-2-methyl-N-propyl-1,4-dihydro-1,8-naphthyridine-3-carboxamide
• CAS: 1197180-32-7
• 化学式: C₁₉H₁₉Br₂N₃O
• 分子量: 465.187
• InChiKey: BMBCQSLVFXATTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  54
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  双乙烯酮 、 2-氨基-5-溴吡啶 、 正丙胺 、 对溴苯甲醛 在 对甲苯磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以76%的产率得到6-bromo-4-(4-bromophenyl)-2-methyl-N-propyl-1,4-dihydro-1,8-naphthyridine-3-carboxamide
  参考文献：
  名称：

  A four-component, one-pot synthesis of highly substituted 1,4-dihydro-1,8-naphthyridine-3-carboxamides

  摘要：

  A new, one-pot, four-component reaction for the synthesis of a novel class of highly substituted 1,4-dihydro-1,8-naphthyridine-3-carboxamide derivatives starting from readily available inputs including aliphatic or aromatic amines, diketene, aromatic aldehydes, and 2-aminopyridines in the presence of a catalytic amount of p-toluenesulfonic acid under mild reaction conditions and in good yields at ambient temperature is described. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2009.08.104

文献信息

• A four-component, one-pot synthesis of highly substituted 1,4-dihydro-1,8-naphthyridine-3-carboxamides
  作者：Ahmad Shaabani、Mozhdeh Seyyedhamzeh、Ali Maleki、Maryam Behnam

  DOI：10.1016/j.tetlet.2009.08.104

  日期：2009.11

  A new, one-pot, four-component reaction for the synthesis of a novel class of highly substituted 1,4-dihydro-1,8-naphthyridine-3-carboxamide derivatives starting from readily available inputs including aliphatic or aromatic amines, diketene, aromatic aldehydes, and 2-aminopyridines in the presence of a catalytic amount of p-toluenesulfonic acid under mild reaction conditions and in good yields at ambient temperature is described. (C) 2009 Published by Elsevier Ltd.