N-(p-tolyl)ethenesulfonamide | 59902-87-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(p-tolyl)ethenesulfonamide
• 英文别名: N-(4-methylphenyl)ethenesulfonamide
• CAS: 59902-87-3
• 化学式: C₉H₁₁NO₂S
• 分子量: 197.258
• InChiKey: KRXVOTUXCWAFAC-UHFFFAOYSA-N

物化性质

• 沸点：
  311.8±35.0 °C(Predicted)
• 密度：
  1.250±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(p-tolyl)ethenesulfonamide 、 乙酸酐 生成 N-acetyl-N-ethenesulfonyl-p-toluidine
  参考文献：
  名称：

  Training to Provide for Healthy Rural Aging

  摘要：

  ABSTRACT:More than 60 percent of the world's aged population is in developing countries, the majority living in rural and remote areas. Resources in these areas are scarce and there is a lack of services and programs, especially in the areas of health, housing and social welfare. The most serious deficiency faced by many countries in meeting the challenges of population aging is the pronounced scarcity of trained caregivers. Little attention has been given to developing effective training policies and programs. Most of the people providing a service to older people lack basic training and this is more so in rural and remote areas. The processes for extending liealthy aging and postponing the onset of chronic diseases and disabling conditions exist already. Unfortunately, these processes are not disseminated in appropriate ways. It is therefore imperative to disseminate this information by training people at the grass roots level to reach the most vulnerable and isolated older people. Primary care workers should have the necessary skills, knowledge and techniques to facilitate good care of older people in their environment. This article reviews and analyzes attempts being made by a number of countries to meet this need. Though the basic issues dealt with are often the same, the approach used differs.

  DOI：

  10.1111/j.1748-0361.2001.tb00284.x
• 作为产物：
  描述：

  ethane-1,2-disulfonyl chloride 、 乙烷,三氯氟- 在 苯 作用下， 生成 N-(p-tolyl)ethenesulfonamide
  参考文献：
  名称：

  Training to Provide for Healthy Rural Aging

  摘要：

  ABSTRACT:More than 60 percent of the world's aged population is in developing countries, the majority living in rural and remote areas. Resources in these areas are scarce and there is a lack of services and programs, especially in the areas of health, housing and social welfare. The most serious deficiency faced by many countries in meeting the challenges of population aging is the pronounced scarcity of trained caregivers. Little attention has been given to developing effective training policies and programs. Most of the people providing a service to older people lack basic training and this is more so in rural and remote areas. The processes for extending liealthy aging and postponing the onset of chronic diseases and disabling conditions exist already. Unfortunately, these processes are not disseminated in appropriate ways. It is therefore imperative to disseminate this information by training people at the grass roots level to reach the most vulnerable and isolated older people. Primary care workers should have the necessary skills, knowledge and techniques to facilitate good care of older people in their environment. This article reviews and analyzes attempts being made by a number of countries to meet this need. Though the basic issues dealt with are often the same, the approach used differs.

  DOI：

  10.1111/j.1748-0361.2001.tb00284.x

文献信息

• Visible-Light-Promoted Radical Cyclization of N-Arylvinylsulfonamides: Synthesis of CF3/CHF2/CH2CF3-Containing 1,3-Dihydrobenzo[c]isothiazole 2,2-Dioxide Derivatives
  作者：Devaiah Vytla、Kumargurubaran Kaliyaperumal、Rajeswari Velayuthaperumal、Parinita Shaw、Raj Gautam、Arvind Mathur、Amrita Roy

  DOI：10.1055/s-0040-1720921

  日期：2022.2

  scope is performed to establish a general, synthetically useful protocol for the synthesis of novel trifluoromethylated 1,3-dihydrobenzo[c]isothiazole 2,2-dioxides in moderate to high yields. This method is also successfully applied for the synthesis of difluoromethylated and trifluoroethylated 1,3-dihydrobenzo[c]isothiazole 2,2-dioxides in good to excellent yields.

  报道了在蓝光 LED 下使用市售的 CF3SO2Cl 作为三氟甲基自由基源对 N-芳基乙烯基磺酰胺进行光催化和高效三氟甲基化。该反应在温和条件下通过自由基环化进行。对底物范围进行了调查，以建立一个通用的、合成有用的协议，用于以中等至高产率合成新型三氟甲基化 1,3-二氢苯并 [c] 异噻唑 2,2-二氧化物。该方法还成功地用于合成二氟甲基化和三氟乙基化 1,3-二氢苯并[c]异噻唑 2,2-二氧化物，收率良好。
• Selective lysine modification of native peptides via aza-Michael addition
  作者：Hongli Chen、Rong Huang、Zhihong Li、Wei Zhu、Jiakang Chen、Yuexiong Zhan、Biao Jiang

  DOI：10.1039/c7ob01866e

  日期：——

  vinylsulfonamides were synthesized and screened for site-selective modification of the ε-amino group of lysine-bearing free α-amine residues. N-methyl-N-phenylethenesulfonamide has emerged as an applicable reagent and has been developed for efficient and highly selective modification of the lysine residue of native peptides in the presence of a free N-terminus via aza-Michael addition. We demonstrated that functional

  合成并筛选了一系列乙烯基磺酰胺，以对带有赖氨酸的游离α-胺残基的ε-氨基进行位点选择性修饰。N-甲基-N-苯基乙磺酰胺已成为一种适用的试剂，并已开发出来，可在存在游离N端的情况下通过氮杂-迈克尔加成反应对天然肽的赖氨酸残基进行高效，高度选择性的修饰。我们证明具有荧光部分或药物的功能性N-苯基乙烯基磺酰胺衍生物也可以高特异性结合到奥曲肽和胰岛素的赖氨酸残基上，而无需修饰N末端。我们的方法为具有游离N末端的天然肽中的位点选择性赖氨酸功能化提供了一种有希望的策略。
• Rapid Access to Aliphatic Sulfonamides
  作者：Mingjun Zhang、Mo Yu、Ziwen Wang、Yuxiu Liu、Qingmin Wang

  DOI：10.1021/acs.orglett.2c01236

  日期：2022.6.10

  Herein, we report a mild, rapid, straightforward method for visible-light-mediated sulfonamide ethylation to afford a diverse array of compounds with C(sp3)–sulfonamide skeletons. The method relies on inexpensive, abundant, commercially available primary, secondary, and tertiary alkyl carboxylic acids and alkyl iodides as substrates. The method has a broad substrate scope and potential utility for

  在此，我们报告了一种温和、快速、直接的可见光介导的磺酰胺乙基化方法，可提供多种具有 C(sp 3 )-磺酰胺骨架的化合物。该方法依赖于廉价、丰富、可商购的伯、仲和叔烷基羧酸和烷基碘作为底物。该方法具有广泛的底物范围和潜在用途，可用于天然产物和合成药物的后期功能化，并有望促进生物活性分子的快速结构多样化。
• Novel Method of Aromatic Coupling between <i>N</i>-Aryl Methanesulfonamide and Thiophene Derivatives
  作者：Alexandre Jean、Jonathan Cantat、Didier Bérard、Denis Bouchu、Sylvain Canesi

  DOI：10.1021/ol070941h

  日期：2007.6.1

  Oxidation of N-aromatic methanesulfonamides with iodobenzene diacetate in the presence of substituted thiophene promotes interesting coupling reactions in moderate to good yields.
• 120. Synthesis of derivatives of taurinamide
  作者：Alan A. Goldberg

  DOI：10.1039/jr9450000464

  日期：——