1,5-di-O-acetyl-2,3,4,6-tetra-O-methyl-D-galactitol

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,5-di-O-acetyl-2,3,4,6-tetra-O-methyl-D-galactitol
• 英文别名: 1,5-di-O-acetyl-2,3,4,6-tetra-O-methylgalactitol；2,3,4,6-Tetra-O-methyl-1,5-di-O-acetyl-galactitol；[(2S,3R,4S,5R)-5-acetyloxy-2,3,4,6-tetramethoxyhexyl] acetate
• 化学式: C₁₄H₂₆O₈
• 分子量: 322.356
• InChiKey: OVCJDQPBVXUBBF-DGAVXFQQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  22
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  89.5
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1,2-O-<(1-exo-cyano)ethylidene>-α-D-galactopyranose 在 吡啶 作用下， 反应 135.0h， 生成 1,5-di-O-acetyl-2,3,4,6-tetra-O-methyl-D-galactitol
  参考文献：
  名称：

  Synthesis of polysaccharides. Communication 15. Synthesis of ?-(1 ? 6)-D-galactan

  摘要：

  DOI：

  10.1007/bf00954103

文献信息

• Structure of the Klebsiella type 10 capsular polysaccharide
  作者：Arun K. Sarkar、Nirmolendu Roy

  DOI：10.1016/s0008-6215(00)90300-8

  日期：1986.9

  The capsular polysaccharide from Klebsiella Type 10 was found to contain D-galactose, D-glucose, D-mannose, and D-glucuronic acid in the ratios 3:1:1:1. Acid hydrolysis of the polysaccharide gave one aldobiouronic acid, one aldotriouronic acid, one aldotetraouronic acid, and two neutral disaccharides the structures of which were established. The native and carboxyl-reduced polysaccharide have been subjected

  发现来自10型克雷伯氏菌的荚膜多糖以3∶1∶1∶1∶1的比例含有D-半乳糖，D-葡萄糖，D-甘露糖和D-葡萄糖醛酸。多糖的酸水解得到一种醛糖二糖醛酸，一种醛糖三糖醛酸，一种醛糖四糖醛酸和两种中性二糖，其结构已确定。天然和羧基还原的多糖已经适当地进行了甲基化分析和史密斯降解。用碱基对甲基化多糖的降解建立了葡糖糖醛酸残基之前的糖单元的身份。糖残基的端基异构构型通过用三氧化铬氧化乙酰化的天然和羧基还原的多糖来确定。根据这些研究，
• A facile method for the synthesis of partially O-methylated alditol acetate standards for GC–MS analysis of galactofuranose-containing structures
  作者：Jian-yu He、Yu-na Guo、Ling-ling Zhang、Lin-hong Huang

  DOI：10.1016/j.carres.2013.06.005

  日期：2013.9

  Mixtures of partially O-methylated alditol acetate standards of galactofuranose were synthesized rapidly. Methyl galactofuranosides were obtained with a yield of 79.9% within 4h under optimized reaction conditions. Methylation of methyl glycosides was carried out in the presence of BaO/Ba(OH)2·8H2O, giving rise to mixtures of partially methylated glycosides. The batch containing the most diverse structures

  快速合成了半乳糖呋喃糖的部分O-甲基化糖醇乙酸酯标准品的混合物。在优化的反应条件下，在4h内获得甲基半乳糖呋喃糖苷的收率为79.9％。在BaO / Ba（OH）2·8H2O的存在下进行甲基糖苷的甲基化，生成部分甲基化糖苷的混合物。将包含最多样化甲基醚结构的批料转化为部分O-甲基化的糖醇乙酸酯（PMAAs），然后进行GC-MS分析。这些PMAA可用作GC-MS标准品，用于同时鉴定在复杂碳水化合物中具有不同键的半乳糖呋喃糖单元。
• Process for preparing neotrehalose and its uses
  申请人：KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO

  公开号：EP0486315A2

  公开（公告）日：1992-05-20

  Neotrehalose is prepared in a relatively high-yield by a process comprising allowing β-galactosidase to act on a solution containing lactoneotrehalose to form neotrehalose and recoverying the resultant neotrehalose. The neotrehalose is a non-reducing oligosaccharide having a satisfiable stability and a rich- and high-quality-sweetness and is assimilated and utilized as energy source in vivo when orally administered. Neotrehalose in the form of crystal has a satisfiable handleability because it is readily soluble in water and substantially free of hygroscopicity. These render neotrehalose very useful in the fields of food-, cosmetic- and pharmaceutical-industries.

  新海藻糖的制备产量相对较高，制备过程包括让 β-半乳糖苷酶作用于含有内酯海藻糖的溶液，形成新海藻糖，并回收所得到的新海藻糖。新海藻糖是一种非还原性低聚糖，具有令人满意的稳定性和丰富优质的甜味，口服后可被人体吸收并用作能量来源。晶体形式的新苏合香糖具有令人满意的可操作性，因为它很容易溶于水，而且基本上没有吸湿性。这些特点使新苏合香糖在食品、化妆品和制药行业中非常有用。
• Trehalose phosphorylase, its preparation and uses
  申请人：KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO

  公开号：EP0841397A2

  公开（公告）日：1998-05-13

  A thermostable trehalose phosphorylase which is obtainable from microorganisms of the genus Thermoanaerobium and which hydrolyzes trehalose in the presence of an inorganic phosphoric acid to form D-glucose and β-D-glucose-1-phosphoric acid. The trehalose phosphorylase can be also prepared by recombinant DNA technology. When the enzyme is allowed to contact with β-D-glucose-1-phosphoric acid as a saccharide donor in the presence of other saccharides, glucosyl-transferred saccharides including glucosyl-D-galactoside, which are conventionally known but scarcely obtainable, can be produced on an industrial-scale and in a relatively-low cost.

  一种可从热花生菌属微生物中获得的热稳定性脱卤糖磷酸化酶，它能在无机磷酸存在下水解脱卤糖，生成 D-葡萄糖和 β-D-葡萄糖-1-磷酸。也可以通过 DNA 重组技术制备妥尔糖磷酸化酶。在有其他糖类存在的情况下，让酶与β-D-葡萄糖-1-磷酸作为糖类供体接触，就能以相对较低的成本在工业规模上生产出葡萄糖基转移的糖类，包括葡萄糖基-D-半乳糖苷。
• ANTI-ALLERGIC AGENT
  申请人：Morishita Jintan Co., Ltd.

  公开号：EP2551283A1

  公开（公告）日：2013-01-30

  According to the present invention, an anti-allergic agent is provided which includes a polysaccharide comprising galactose, glucose and rhamnose as constituents, or includes a microorganism belonging to the genus Bifidobacterium and extracellularly producing the polysaccharide. The anti-allergic agent of the present invention can be used in oral compositions and compositions for external application, and is suitable for use in products such as food products, pharmaceutical products, and cosmetics.

  根据本发明，提供了一种抗过敏剂，它包括一种以半乳糖、葡萄糖和鼠李糖为成分的多糖，或包括一种属于双歧杆菌属并在细胞外产生该多糖的微生物。本发明的抗过敏剂可用于口服组合物和外用组合物，并适用于食品、药品和化妆品等产品。